Dr. Jan Vincent Arafiles


Academic positionPost Doc
Research fieldsBioorganic and Biological Chemistry,Biochemistry
KeywordsCorrelative super-resolution microscopy and electr, Bioconjugation, Intracellular delivery, Chemical biology, Bicyclic cell-penetrating peptide
Honours and awards

2015: Japanese Government (Monbukagakusho) Scholarship

Current contact address

InstitutionLeibniz-Institute of Molecular Pharmacology (FMP)
InstituteChemical Biology II

Host during sponsorship

Prof. Dr. Christian Peter Richard HackenbergerAbteilung Chemische Biologie, Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin


2022Humboldt Research Fellowship Programme for Postdocs

Publications (partial selection)

2020Hsu, Wei-Yuan and Masuda, Toshihiro and Afonin, Sergii and Sakai, Takayuki and Arafiles, Jan Vincent V. and Kawano, Kenichi and Hirose, Hisaaki and Imanishi, Miki and Ulrich, Anne S. and Futaki, Shiroh: {Enhancing the activity of membrane remodeling epsin-peptide by trimerization}. In: Bioorganic & Medicinal Chemistry Letters, 30, 2020, 127190
2020Futaki, Shiroh and Arafiles, Jan Vincent V. and Hirose, Hisaaki: {Peptide-assisted Intracellular Delivery of Biomacromolecules}. In: Chemistry Letters, 49, 2020, 1088--1094
2020Arafiles, Jan Vincent V. and Hirose, Hisaaki and Akishiba, Misao and Tsuji, Shogo and Imanishi, Miki and Futaki, Shiroh: {Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane-Lytic Peptides to Facilitate Endosomal Escape}. In: Bioconjugate Chemistry, 31, 2020, 547--553
n.n.Sakamoto, Kentarou and Furukawa, Hiroto and Arafiles, Jan Vincent and Imanishi, Miki and Matsuura, Kazunori and Futaki, Shiroh: {Artificial Nanocage Formed via Self-Assembly of $\beta$-Annulus Peptide for Delivering Biofunctional Proteins into Cell Interiors}. In: Bioconjugate Chemistry, 33, n.n., 311 -- 320
n.n.Nagano, Yuki and Arafiles, Jan Vincent and Kuwata, Keiko and Kawaguchi, Yoshimasa and Imanishi, Miki and Hirose, Hisaaki and Futaki, Shiroh: {Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein–Protein Interactions on a Cell-Penetrating Peptide Scaffold}. In: Molecular Pharmaceutics, 0, n.n., null -- null
n.n.Nakagawa, Yuna and Arafiles, Jan Vincent and Kawaguchi, Yoshimasa and Nakase, Ikuhiko and Hirose, Hisaaki and Futaki, Shiroh: {Stearylated Macropinocytosis-Inducing Peptides Facilitating the Cellular Uptake of Small Extracellular Vesicles}. In: Bioconjugate Chemistry, 0, n.n., null -- null