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Prof. Dr. Willem A. L. Van Otterlo

Van Otterlo, Prof. Dr. Willem A. L.

University of Stellenbosch, South Africa
Fachgebiet: Organic chemistry
Gastgeber: Prof. Dr. Herbert Waldmann Max-Planck-Institut für molekulare Physiologie
  • Steffen Renner, Willem A. L. van Otterlo, Marta Dominguez Seoane, Sabine Möcklinghoff, Bettina Hofmann, Stefan Wetzel, Ansgar Schuffenhauer, Peter Ertl, Tudor I. Oprea, Dieter Steinhilber, Luc Brunsveld, Daniel Rauh, Herbert Waldmann: Bioactivity-guided mapping and navigation of chemical space. In: Nature Chemical Biology. 5, 2009, p. 585 - 592 [Bioactivity, scaffolds, chemical space, synthesis, tetrahydroisoquinolines, estrogen receptor alpha, 5-lipoxygenase].

  • Willem A. L. van Otterlo, Charles B. de Koning: Metathesis in the Synthesis of Aromatic Compounds. In: Chemical Reviews. 109, 2009, p. 3743 - 3782 [Metathesis, Aromatic compounds, Aromatization, Heterocycles].

  • Vijay Pawar, Martin Sos, Haridas B. Rode, Mattheus Rabiller, Stefanie Heynck, Willem A. L. van Otterlo, Roman Thomas, Daniel Rauh.*: Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of EGFR. In: Journal of Medicinal Chemistry. 53, 2010, p. 2892 - 2901 [4-Anilinoquinolines, kinase, inhibitors, EGFR, cancer].

  • Sabine Klüter, Jeffrey R. Simard, Haridas B. Rode, Vijay Pawar, Hans C.A. Raaijmakers, Tjeerd A. Barf, Christian Grütter, Matthias Rabiller, Willem A.L. van Otterlo and Daniel Rauh.*: Characterization of irreversible kinase inhibitors by detecting fluorescent changes during covalent bond formation. In: ChemBioChem. 11, 2010, p. 2557 - 2566 [Drug resistance, Fluorescence spectroscopy, Kinases, Inhibitors, Irreversible].


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