Prof. Dr. Ilza K. Pajeva

Profile

Academic positionFull Professor
Research fieldsPharmacy,Software Engineering and Programming Languages
KeywordsABC transporters, Computer Aided Drug Design, Molecular modeling, Multidrug Resistance,MDR, Quantitative Structure-Activity Relationships,QSAR

Current contact address

CountryBulgaria
CitySofia
InstitutionBulgarian Academy of Sciences
InstituteInstitute of Biophysics and Biomedical
Homepagewww.clbme.bas.bg

Host during sponsorship

Prof. Dr. Joachim K. SeydelInstitut für Experimentelle Biologie und Medizin, Forschungszentrum Borstel – Leibniz-Lungenzentrum (FZB), Borstel
Prof. Dr. Michael WieseAbteilung Pharmazeutische Chemie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn
Start of initial sponsorship01/01/1993

Programme(s)

1992Humboldt Research Fellowship Programme

Publications (partial selection)

2013Ilza K. Pajeva, Katja Sterz, Kerstin Steggemann, Federico Marighetti, Mathias Christlieb, Michael Wiese: Interactions of the multidrug resistance modulators tariquidar and elacridar and their analogs with P-glycoprotein. In: ChemMedChem, 2013, 1701-1713
2013Ilza K. Pajeva, Markus Hanl, Michael Wiese: Protein contacts and ligand binding in the inward-facing model of human P-glycoprotein. In: ChemMedChem, 2013, 748-762
2013Filip Fratev, Svava Jónsdóttir, Ilza Pajeva: Structural insight into the UNC-45-Myosin complex. In: Proteins, 2013, 1212-1221
2012Tania Pencheva, David Lagorce, Ilza Pajeva, Bruno Villoutreix, Maria Miteva: AMMOS Software: Method and Application. In: Riccardo Baron, Computational Drug Discovery and Design (Methods Mol. Biol.). Springer New York, 2012. 127-141
2012Dessislava Jereva, Ilza Pajeva, Tania Pencheva: Data extraction module – a supplementary tool for AMMOS_ProtLig software package. In: Comput Math Appl, 2012, 266-271
2012Iglika Lessigiarska, Ilza Pajeva, Penka Prodanova, Maria Georgieva, Atanas Bijev: Structure-activity relationships of pyrrole hydrazones as new anti-tuberculosis agents. In: Medicinal Chemistry, 2012, 462-473
2011Ilza K. Pajeva, Michael Wiese: Application of In Silico Methods to Study ABC Transporters Involved in Multidrug Resistance. In: Maria A. Miteva, In Silico Lead Discovery . Bentham Science, 2011. 144-162
2011Ivanka Tsakovska, Ilza Pajeva, Petko Alov, Andrew Worth: Recent advances in the molecular modelling of estrogen receptor-mediated toxicity. In: Adv Protein Chem Struct Biol, 2011, 217-251
2011Anne Pick, Henrik Müller, Ralf Mayer, Britta Haenisch, Ilza K. Pajeva, Mathias Weigt, Heinz Bönisch, Christa E. Müller, Michael Wiese Structure-Activity Relationships of Flavonoids ss Inhibitors of Breast Cancer Resistance Protein (BCRP). In: Bioorg. Med. Chem., 2011, 2090-2102
2011Ilza K. Pajeva: Zeit - abhängig Präsentationen der Wechselwirkungen von Arzneistoffen. In: Dietmar Goltschnigg, Phänomen Zeit: Dimensionen und Strukturen in Kultur und Wissenschaft . Stauffenburg Verlag 2011. 307-308
2010Tania Pencheva, O.S. Sumana, Ilza K. Pajeva, Maria Miteva: Post-docking virtual screening of diverse binding pockets: Comparative study using DOCK, AMMOS, X-Score and FRED scoring functions. In: Eur J Med Chem, 2010, 2622-2628
2009Ilza K. Pajeva Christoph Globisch, Michael Wiese Combined pharmacophore modeling, docking and 3D QSAR study of ABCB1 and ABCC1 transporter inhibitors. In: ChemMedChem, 2009, 1883-1896
2009Ilza K. Pajeva, Christoph Globisch, Michael Wiese Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein. In: FEBS J, 2009, 7016-7026
2009Ilza K. Pajeva, Michael Wiese: Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators. In: The AAPS Journal, 2009, 435-444
2008Christoph Globisch Ilza K. Pajeva Michael Wiese: Identification of Putative Binding Sites of P-glycoprotein Based on its Homology Model. In: ChemMedChem, 2008, 280-295
2008Christoph Globisch Ilza Pajeva Michael Wiese: Identification of putative binding sites of P-glycoprotein based on its homoliogy model. In: ChemMedChem, 2008, 280-295
2007Michael Wiese Ilza Pajeva: Comprehensive Medicinal Chemistry II. Elsevier, 2007
2005Ilza Pajeva Christoph Globisch Romy Fleisher Ivanka Tsakovska Michael Wiese: Molecular modeling of P-glycoprotein and related drugs. In: Med. Chem. Res., 2005, 106-117
2004Ilza K. Pajeva Dimitar K. Todorov Joachim K. Seydel: Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol. In: Europ. J. Pharm. Sci, 2004, 243-250
2003Ivanka M. Tsakovska Ilza K. Pajeva Michael Wiese: Molecular modeling of phenothiazines and structurally related multidrug resistance modulators: comparative study in human and animal tumor cell lines. In: Biotechnol. Biotechn. Eq., 2003, 163-169
2002Ilza K. Pajeva, M. Wiese: Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (Hypothesis). In: J. Med. Chem., 2002, 5671-5686