Prof. Dr. Slobodan Rendic

Profile

Academic positionEmeritus
Research fieldsPharmacy,Nutritional Sciences,Biochemistry
KeywordsBochemistry, Drug Metabolism, Pharmaceutical Chemistry, Metabolic Databases, Doping Control

Current contact address

CountryCroatia
CityZagreb
InstitutionUniversity of Zagreb
InstituteDepartment of Pharmaceutical Chemistry

Host during sponsorship

Prof. Dr. Karl-Ernst SchulteInstitut für Pharmazeutische und Medizinische Chemie, Universität Münster, Münster
Prof. Dr. Volker UllrichF2 -Medizin, Bereich Theoretische Medizin, Biowissenschaften und Klinische Medizin, Universität des Saarlandes, Homburg
Prof. Dr. Volker UllrichFachbereich Biologie, Universität Konstanz, Konstanz
Prof. Dr. Wilhelm SchänzerInstitut für Biochemie, Deutsche Sporthochschule Köln, Köln
Start of initial sponsorship01/09/1975

Program(s)

1975Humboldt Research Fellowship Programme

Publications (partial selection)

2024Slobodan Petar Rendic, Guengerich, F.P. Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes. In: Arch Toxicol , 2024,
2022Slobodan Petar Rendic, Crouch RD, Guengerich FP. Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. In: Arch Toxicol. 96, 2022, 2145-2246
2021S. Rendić: Metabolism and Interactions of Ivermectin with Human Cytochrome P450 Enzymes and Drug Transporters, possible adverse and toxic effects. In: Arch Toxicol., 95, 2021, 1535-1546
2020S. Rendić, F.P. Guengerich: Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters. In: Curr Drug Metab., 21, 2020, 1127-1135
2018S. Rendić, F.P. Guengerich: Development and Uses of Offline and Web-Searchable Metabolism ADME Databases - The Case of Benzo[a]pyrene. In: Curr Drug Metab., 19, 2018, 3-46
2018S. Rendić, F.P. Guengerich: Human cytochrome P450 enzymes 5–51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition – toxic effects and benefits. In: Drug Metab Rev., 50, 2018, 256-342
2015S. Rendić, F.P. Guengerich: Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Chemicals. In: Chem Res Toxicol., 28, 2015, 38-42
2012S. Rendić, F.P. Guengerich: Contributions of Human Enzymes in Carcinogen Metabolism. In: Chem Res Toxicol., 25, 2012, 1316-83
2012S. Rendić, F.P. Guengerich: Summary of Information on the Effects of Ionizing and Non-ionizing Irradiation on Cytochrome P450 and Other Drug Metabolizing Enzymes and Transporters. In: Curr Drug Metab., 13, 2012, 787-814
2010F.P. Guengerich, S. Rendić: Update Information on Drug Metabolism Systems—2009, Part I. In: Curr Drug Metab., 11, 2010, 1-3
2010S. Rendić, F.P. Guengerich: Update Information on Drug Metabolism Systems—2009, Part II. Summary of Information on the Effects of Diseases and Environmental Factors on Human Cytochrome P450 (CYP) Enzymes and Transporters. In: Curr Drug Metab., 11, 2010, 4-84
2004S. Rendić: Strategies for more effective and reliable ADME. In: Expert Opin Drug Saf., 3, 2004, 379-80
2002Slobodan Rendic: Summary of information on human CYP enzymes: human P450 metabolism data. In: Drug Metabolism Reviews, 2002, 83-448
1999S. Rendić: Cytochrome P450 enzymes (CYP ENZYMES): Role in toxic effects of xenobiotics. In: Biochemia Medica, 9, 1999, 107-113
1999Slobodan Rendic: Drug Interactions of H2- receptor antagonists involving cytochrome P450 enzymes (CYPs): from laboratory to the clinic. In: Croatian Medical Journal, 40, 1999, 357-367
1999S. Rendić, E. Nolteernsting, W. Schänzer Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes: gas chromatographic-mass spectrometric determination of metabolites. In: J Chromatogr B Biomed Sci Appl., 735, 1999, 73-83
1998S. Rendić: Human Recombinant Erythropoietin (rhEPO) – Physiology and Biochemistry. In: Recent Advances in Doping Analysis, Proceedings of the 15th Cologne Workshop on Dope Analysis, 5, 1998, 191-208
1997S. Rendić: Drug interaction in biosynthesis and metabolism of steroid hormones: The role of human cytochrome P450s. In: Recent Advances in Doping Analysis, Proceedings of the 14th Cologne Workshop on Dope Analysis, 17th to 22nd March 1996, 4, 1997, 21-31
1997Slobodan Rendic, Frederick J. Di Carlo: Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers and Inhibitors. In: Drug Metabolism Reviews, 29, 1997, 413-580
1995S. Rendić: Biotransformation of drugs by human cytochromes P450 (CYP): Toxic effects, activations, and drug-drug interactions. In: Medicus, 4, 1995, 175-192
1995S. Rendić: Human cytochrome P450 (CYP) enzymes in doping control: metabolism, interactions, adverse effects. In: Recent Advances in Doping Analysis, Proceedings of the 13th Cologne Workshop on Dope Analysis, 3, 1995, 13-53
1995S. Rendić: The role and nature of metabolic reactions catalyzed by enzymes cytochrome P450 (CYP) in biological effects of medicines. In: Medicus, 4, 1995, 49-66
1994V. Vestemar, M. Medić-Šarić, S. Rendić: Binding of (+)- and (-)-isomers and racemate of etomoxir to HSA, and effect of stearic acid and stanozolol. In: J Pharm Sci, 83, 1994, 485-90
1994S. Rendić, M. Medić-Šarić, B. Jurišić, and V. Vestemar: Binding of anabolic steroids to Human Serum Albumin and possible interactions with other drugs. In: Recent Advances in Doping Analysis, Proceedings of the 12th Cologne Workshop on Dope Analysis, 2, 1994, 15-37
1994S. Rendić: Biochemistry of drug metabolism studies: Metabolism of testosterone and T/E ratio. In: Acta Pharm., 44, 1994, 215-227
1994S. Nikolić, M. Medić-Šarić, S. Rendić, N. Trinajstić: Toxic effects and structure-property study of organic explosives, propellants and related compounds . In: Drug Metab. Rev., 26, 1994, 717-38
1994S. Rendić, M. Slavica, M. Medić-Šarić: Urinary excretion and metabolism of orally administered Mefenorex . In: Eur J Drug Metab Pharmacokinet., 19, 1994, 197-17
1993M. Medić-Šarić, S. Rendić, V. Vestemar, S. Šarić: A comparative study of some topological indices and logP in structure-property activity analysis of phenylalkylamines . In: Acta Pharm, 43, 1993, 15-26
1993S. Rendić: Metabolism of testosterone. In: Proceedings of the 10th Cologne Workshop on Dope Analysis,, 1993, 27-46
1992D. Catlin, D. Cowan, M. Donike, D. Fraisse, H. Oftebro, S. Rendić: Testing urine for drugs. In: Clin Chim Acta, 15, 1992, S13-S26
1990Slobodan Rendic, Peter Weber, Volker Ullrich: In vitro testing of drugs and chemicals for stable and reactive metabolites. In: Acta Pharmaceutica Jugoslavica, 1990, 409-422
1990S. Rendić, P. Weber, V. Ullrich: In vitro testing of drugs and chemicals for stable and reactive metabolites . In: Acta Pharm. Jugosl., 40, 1990, 409-422
1989S. Rendić: Meeting report on the 5th Otzenhausen Conference on “Metabolism of Dope Agents”, 1989. 5th Otzenhausen Conference on Metabolism of Dope Agents, Europaeische Academie, Otzenhausen, Germany. In: Acta Pharm. Jugosl., 39, 1989, 365
1988S. Rendić, H.H. Ruf: Interaction of stanozolol with cytochrome P450. In: Biochem Pharmacol. 37, 1988, 766-768
1985I. Vukušić, S. Rendić, Z. Fuks: Biotransformation and plasma-level curves of chiral 1,4-benzodiazepine-2-ones. In: J. Drug Metab. Pharmacokin., 10, 1985, 265-72
1985S. Rendić, H.H. Ruf: Characterization of pirenzepine interaction with cytochrome P450,. In: Xenobiotica, 15, 1985, 399-405
1984S. Rendić, H.H. Ruf, P. Weber, F. Kajfež: Cimetidine and ranitidine: Their interaction with human and pig liver microsomes and with purified cytochrome P450. In: Europ. J. Drug Metab. Pharmacokin. 9, 1984, 195-200
1983Slobodan Rendic, Franjo Kajfez, Hans-Heinrich Ruf: Characterization of cimetidine, ranitidine and related structures' interaction with cytochrome P450. In: Drug Metabolism and Disposition, 1983, 137-142
1982Slobodan Rendic, Tanja Alebic-Kolbah, Franjo Kajfez, Hans-Heinrich Ruf: Interaction of ranitidine with liver microsomes. In: Xenobiotica, 1982, 9-17
1982V. Čaplar, S. Rendić, F.Kajfež, H. Hofman, J. Kuftinec, N. Blažević: Physico-chemical and analytical characteristics of captopril. In: Acta Pharm. Jugosl., 32, 1982, 125-136
1982Wolfgang Nanstaynczik, Slobodan Rendic, Volker Ullrich, R. Krüger: Prevention by metyrapone of halothane induced liver necrosis in rats. In: Anaesthesist, 1982, 181-184
1982S. Rendić, F. Kajfež: Stereochemical characterization of interactions of chiral 1,4-benzodiazepine-2-ones with liver microsomes. In: Europ. J. Drug Metabol. Pharmacokin. 7, 1982, 137-46
1981S. Rendić, T. Alebić-Kolbah, F. Kajfež: Binding of piroxicam to human serum albumin. In: Acta Pharm Jugosl, 31, 1981, 215-220
1981M. Hohnjec, S. Rendić, T. Alebić-Kolbah, F. Kajfež, N. Blažević, J. Kuftinec: Physical and spectroscopic data on ranitidine. In: Acta Pharm. Jugosl., 31, 1981, 131-142
1980S. Rendić, F. Kajfež, G. Gratton, V. Šunjić: Chiroptical properties of binding of desmethyldiazepam to human serum albumin. In: Acta Pharm. Jugosl. 30, 1980, 1-7
1980S. Rendić, F. Kajfež: Interaction of desmethyldiazepam with rat liver microsomes. In: Acta Pharm Jugosl., 30, 1980, 141-149
1980S. Rendić, T. Alebić-Kolbah, F. Kajfež V. Šunjić: Stereoselective binding of (+)- and (-)--benzoylphenyl)-propionic acid (ketoprofen) to human serum albumin . In: Il Pharmaco-Ed. Sc., 35, 1980, 51-59
1979T. Alebić-Kolbah, S. Rendić, G. Gratton, F. Kajfež: Binding of drugs to serum proteins. In: Acta Pharm. Jugosl., 29, 1979, 1-13
1979T. Alebić-Kolbah, S. Rendić, V. Šunjić, F. Kajfez, A. Konowal, G. Snatzke, Circular dichroism, and gel filtration study of the binding of prochiral and chiral 1,4-benzodiazepine-2-ones. In: Biochem. Pharmacol., 28, 1979, 2457-64
1979T. Alebić-Kolbah, S. Rendić, Z. Fuks, V. Šunjić, F. Kajfež: Enantioselectivity in the binding of drugs to serum proteins. In: Acta Pharm. Jugosl., 20, 1979, 53-70
1979A. Konowal, G. Snatzke, T. Alebić-Kolbah, F. Kajfež, S. Rendić V. Šunjić: General approach to chiroptical characterization of the binding of prochiral and chiral 1,4-benzodiazepine-2-ones to human serum albumin. In: Biochem. Pharmacol., 28, 1979, 3109-13
1979Slobodan Rendic, Vitomir Sunjic, Roberto Toso, Franjo Kajfez, Han-Heinrich Ruf: Interactions of cimetidine with liver microsomes. In: Xenobiotica, 1979, 555-564
1979G. Gratton, S. Rendić, V. Šunjić, F. Kajfež: Stereoselective binding of chiral 7-chloro-1,3-dihydro-3-(S- and R-)-isopropylphenyl-2H-1,4-benzodiazepin-2-ones to human serum albumin, . In: Acta Pharm. Jugosl., 29, 1979, 119-124
1978K.E. Schulte, Slobodan Rendic, R.I. Mrongovius: Malimide: a urinary metabolite of succinimide in the rat. In: European Journal of Drug Metabolism and Pharmacokinetics, 1978, 3249-250
1978K.E. Schulte, SLobodan Rendic, G. Henke, R.I. Mrongovius: Pharmacokinetics and disposition of orally administered [2,3-14C]-succinimide in the rats. In: European Journal of Drug Metabolism and Pharmacokinetics, 1978, 31-38
1977D. Kolbah, N. Blažević, M. Hannoun, F. Kajfež, T. Kovać, S. Rendić, V. Šunjić: Stereoselective in vitro aromatic ring oxygenations of chiral 1,4-benzodiazepin-2-ones. In: Helv. Chim. Acta, 60, 1977, 265-283
1975S. Rendić, V. Šunjić, F. Kajfež, N. Blažević, P. Mildner: Biotransformation of 1,4-benzodiazepines. In: Acta Pharm. Jugoslav. 25, 1975, 135-153
1975S. Rendić, L. Klasinc, V. Šunjić, F. Kajfež, V. Kramer, P. Mildner: Mass Spectrometry of 1,4-benzodiazepines. In: Biomedical Mass Spectrometry, 2, 1975, 97-106
1975S. Rendić, V. Šunjić, F. Kajfež, N. Blažević, T. Alebić-Kolbah: Resolution of (+/-)--(3-benzoylphenyl)-propionic acid (Ketoprofen) and diastereoisomeric interactions of its enantiomers with some biological systems. In: Chimia, (Aarau), 29, 1975, 170-172
1975S. Rendić, F. Kajfež, B. Zamola, P. Valles, P. Mildner: Study of the sporulation of Bacillus thuringiensis var. thuringiensis. In: Boll Ist Sieroter Milan., 54, 1975, 98-104
1974S. Rendić, V. Šunjić, F. Kajfež, L. Klasinc, P. Mildner: Stereoselectivity in enzymatic biotransformation of chiral and achiral 1,3-dihydro-2H-1,4-benzodiazepin-2-ones. In: Chimia (Aarau), 28, 1974, 232-234
1973V. Šunjić, M. Štromar, F. Kajfež, S. Rendić, D. Kolbah: Chiral 1,4-benzodiazepines. VI. Preparation and purification of 3-(S)-methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one. In: Chiral 1,4-benzodiazepines. VI. Preparation and purification of 3-(S)-methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one, 23, 1973,
1970B. Zamola, S. Rendić, F. Kajfež, G. Tamburašev: Investigation of aeration effect on the sporulation of Bacillus thuringiensis. In: Mikrobiologija, 7, 1970, 117-122
1966S. Rendić: Drug interaction in biosynthesis and metabolism of steroid hormones: The role of human cytochrome P450s. In: Recent Advances in Doping Analysis, Proceedings of the 14th Cologne Workshop on Dope Analysis, 17th to 22nd March 1996, 4, 1966, 21-31