Priv. Doz. Dr. Axel Sckell

Profile

Academic positionLecturer, Assistant Professor, Researcher
Research fieldsOrthopaedics, Traumatology, Reconstructive Surgery,Anatomy and Physiology,Haematology, Oncology
KeywordsAngionese, Intravitalmikroskopie, Knochentransplantation, Mikrozirkulation, Tumor

Current contact address

CountryGermany
CityRostock
InstitutionUniversität Rostock
InstituteChirurgische Klinik und Poliklinik

Host during sponsorship

Prof. Dr. Rakesh K. JainMassachusetts General Hospital, Department of Radiation Oncology COX7, Harvard Medical School, Boston
Dr. Michael LeunigKlinik und Poliklinik für Orthopädische Chirurgie, Universität Bern, Bern
Start of initial sponsorship16/02/1996

Programme(s)

1995Feodor Lynen Research Fellowship Programme

Publications (partial selection)

2005F.M. KLENKE, T. MERKLE, M.M. GEBHARD, V. EWERBECK, A. SCKELL: A novel model for the investigation of orthotopically growing primary and secondary bone tumors using intravital microscopy. In: Lab Anim, 2005, 377-383
2003A. ABDOLLAHI, K.E. LIPSON, A. SCKELL, H. ZIEHER, F.M. KLENKE, D. POERSCHKE, A. ROTH, X. HAN, M. KRIX, M. BISCHOF, P. HAHNFELDT, H.-J. GRONE, J. DEBUS, L. HLATKY, P.E. HUBER: Combined therapy with direct and indirect angiogenesis inhibiton results in enhanced antiangiogenic and antitumor effects. In: Cancer Res, 2003, 8890-8898
2003R.J. EGLI, A. SCKELL, C.R. FRAITZL, R. FELIX, R. GANZ, W. HOFSTETTER, M. LEUNIG: Cryopreservation with dimethyl sulfoxide sustains partially the biological function of osteochondral tissue. In: Bone, 2003, 352-361
2003A. SCKELL, T.J. DEMHARTNER, C.R. FRAITZL, R. GANZ, M. LEUNIG: Reperfusion injury in free bone grafts after tourniquet-ischemia. In: Clin Orthop, 2003, 306-316
2002G. HELMLINGER, A. SCKELL, M. DELLIAN, N.S. FORBES, R.K. JAIN: Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. In: Clin Cancer Res, 2002, 1284-1291
2001C.R. FRAITZL, M. LEUNIG, T.J. DEMHARTNER, A. SCKELL, R. GANZ, W. HOFSTETTER: Development of transplanted fetal bones: Differences between isografts and allografts in mice. In: Clin Orthop, 382: 267-276, 2001, 2001, 267-276
2001A. SCKELL, M. LEUNIG: Dorsal skinfold chamber preparation in mice: Studying angiogenesis by intravital microscopy. In: J.C. Murray, Methods in molecular medicine - angiogenesis protocols. Humana Press Inc, 2001. 95-105
2000Y. H. Tian, T. Schafer, A. Sckell, M. K. Schilling: Adenosine deaminase inhibition attenuates reperfusion low flow and improves graft survival after rat liver transplantation. In: Transplantation, 2000, 2277-2281
2000W.M. KUEBLER, J. BORGES, A. SCKELL, G.E.H. KUHNLE, K. BERGH, A.E. GOETZ: Role of L-selectin in leukocyte sequestration in lung capillaries in a rabbit model of endotoxemia. In: Am Rev Respir Crit Care Med, 2000, 36-43
1999L. NEY, G. KEMMING, W.M. KUEBLER, A. SCKELL, A.E. GOETZ: Dosage of inhaled nitric oxide: A simple method for experimental studies. In: Res Exp Med (Berl), 1999, 121-128
1999G.E.H. KUHNLE, R. KIEFMANN, A. SCKELL, W.M. KUEBLER, J. GROH, A.E. GOETZ: Leukocyte sequestration in pulmonary microvessels and lung injury following systemic complement activation in rabbits. In: J Vasc Res, 1999, 289-298
1999M. LEUNIG, T.J. DEMHARTNER, A. SCKELL, C.R. FRAITZL, N. GRIES, R.K. SCHENK, R. GANZ: Quantitative assessment of angiogenesis and osteogenesis after transplantation of bone: Comparison of isograft and allograft bone in mice. In: Acta Orthop Scand, 1999, 374-380
1999D. CÉFAI, B.W. MORRISON, A. SCKELL, L. FAVRE, M. BALLI, M. LEUNIG, C.D. GIMMI: Targeting HER-2/neu for active-specific immunotherapy in a mouse model of spontaneous breast cancer. In: Int J Cancer, 83: 393-400, 1999, 1999, 393-400
1999A. SCKELL, M. LEUNIG, C.R. FRAITZL, R. GANZ, F.T. BALLMER: The connective-tissue envelope in revascularization of patellar tendon grafts. In: J Bone Joint Surg, 1999, 915-920
1998J. BORGES, A. SCKELL, W.M. KUEBLER, A.E. GOETZ, K. MESSMER: Effect of humanized anti-L-selectin antibody HuDreg 200 on leukocyte kinetics in pulmonary microcirculation during endotoxinemia. In: Langenbecks Arch Chir, 1998, 709-711
1998R.K. JAIN, N. SAFABAKHSH, A. SCKELL, Y. CHEN, P. JIANG, L. BENJAMIN, F. YUAN, E. KESHET: Endothelial cell death, angiogenesis and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor. In: Proc Natl Acad Sci (USA), 1998, 10820-10825
1998W.M. KUEBLER, A. SCKELL, O. HABLER, M. KLEEN, G.E.H. KUHNLE, M. WELTE, K. MESSMER, A.E. GOETZ: Noninvasive measurement of regional cerebral blood flow by near-infrared spectroscopy and indocyanine green. In: J Cereb Blood Flow Metab, 1998, 445-456
1998A. SCKELL, N. SAFABAKHSH, M. DELLIAN, R.K. JAIN: Primary tumor size-dependent inhibition of angiogenesis at a secondary site: An intravital microscopic study in mice. In: Cancer Res, 1998, 5866-5869
1996W.M. KUEBLER, G.E.H. KUHNLE, J. GROH, A. SCKELL, A.E. GOETZ: Increased leukocyte sequestration in alveolar capillaries in low flow state is due to retarded entry into narrow capillary segments. In: K. Messmer, W.M. Kuebler, 6th World Congress for Microcirculation. Monduzzi Editore, International Proceedings Division, 1996. 755-759
1995J. GROH, G.E.H. KUHNLE, L. NEY, A. SCKELL, A.E. GOETZ: Effects of isoflurane on regional pulmonary blood flow during one-lung ventilation. In: Br J Anesthesiol, 1995, 209-216
1995J. GROH, G.E.H. KUHNLE, L. NEY, A. SCKELL, A.E. GOETZ: Effects of mechanical ventilation, thoracotomy, and one-lung ventilation on regional pulmonary blood flow. An experimental study in rabbits. In: Anaesthesist, 1995, 319-327
1994J. GROH, G.E.H. KUHNLE, A. SCKELL, L. NEY, A.E. GOETZ: Isoflurane inhibits hypoxic pulmonary vasoconstriction: An in vivo fluorescence microscopic study in rabbits. In: Anesthesiology, 1994, 1436-1444