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Profile
| Academic position | Full Professor |
|---|---|
| Research fields | Cell Biology,General Genetics, Functional Genome Research |
| Keywords | Animal Models, Myopathy, Signal Transduction, Stretch, Titin |
| Honours and awards | 2023: ERC advanced grant 2012: ERC starting grant 2001: Sofja Kovalevskaya Award 1999: DFG Postdoc Fellowship |
Current contact address
| Country | Germany |
|---|---|
| City | Berlin |
| Institution | Max-Delbrück-Centrum für Molekulare Medizin (MDC) |
| Institute | Forschungsgruppe Neuromuskuläre und kardiovaskuläre Zellbiologie |
Host during sponsorship
| Prof. Dr. Thomas Willnow | Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin |
|---|---|
| Start of initial sponsorship | 01/01/2002 |
Programme(s)
| 2001 | Sofja Kovalevskaja Award Programme |
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Nominator's project description
| Dr. Michael Gotthardt was trained as a physician in Heidelberg, Berlin and Boston. In 1997, he completed his doctoral thesis at the Humboldt University in Berlin, working on the development of adenoviral vectors for somatic gene therapy. He continued his studies at the Southwestern Medical Center in Dallas where he generated several mouse models of cardiovascular diseases, including a line of mice carrying a genetic defect of the muscle protein titin, an important animal model of cardiomyopathy. Focus of his future work will be the elucidation of the role of titin in muscle and non-muscle tissues leading to novel strategies for treatment of cardiovascular diseases. |
Publications (partial selection)
| 2007 | Gotthardt M; Peng J; Raddatz K; Molkentin JD; Wu ;Y; Labeit S; Granzier H; Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. In: Circulation, 2007, 743-751 |
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| 2007 | Granzier HL; Radke MH; Royal J; Wu Y; Irving TC; Gotthardt M; Labeit S: Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle . In: American Journal of Physiology, 2007, R557-R567 |
| 2007 | Jansen P; Giehl K; Nyengaard JR; Teng K; Lioubinski O; Sjoegaard SS; Breiderhoff T; Gotthardt M; Lin F; Eilers A; Petersen CM; Lewin GR; Hempstead BL; Willnow TE; Nykjaer A: Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury . In: Nature Neuroscience , 2007, 1449-1457 |
| 2007 | Gotthardt M; Radke MH; Peng J; Wu Y; McNabb M; Nelson OL; Granzier H: Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy . In: Proceedings of the National Academy of Sciences of the United States of America, 2007, 3444-3449 |
| 2006 | Gotthardt M; Raddatz K: Cardiac signaling: cellular, molecular and clinical aspects . In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine , 2006, 208-214 |
| 2006 | Weinert S; Bergmann N; Luo X; Erdmann B; Gotthardt M: M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere . In: Journal of Cell Biology , 2006, 559-570 |
| 2005 | Peng J; Raddatz K; Labeit S; Granzier H; Gotthardt M: Muscle atrophy in titin M-line deficient mice . In: Journal of Muscle Research and Cell Motility , 2005, 381-388 |
| 2005 | Andersen OM; Reiche J; Schmidt V; Gotthardt M; Spoelgen R; Behlke J; von Arnim CAF; Breiderhoff T; Jansen P; Wu X; Bales KR; Cappai R; Masters CL; Gliemann J; Mufson EJ; Hyman BT; Paul SM; Nykjaer A; Willnow TE: Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein . In: Proceedings of the National Academy of Sciences of the United States of America , 2005, 13461-13466 |
| 1994 | M.Gotthardt, M.Strauss: Possibilities and Limitations of Gene Therapy. In: Monatsschr Kinderheilkd, 1994, 930-940 |