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Dr. Florian Rehfeldt

Profile

Academic positionLecturer, Assistant Professor, Researcher
Research fieldsBiophysics,Medical Physics, Biomedical Engineering
Keywordsbiophysics, cytoskeleton, extracellular matrix, human adult stem cells, mechanical properties of cells

Current contact address

CountryGermany
CityBayreuth
InstitutionUniversität Bayreuth
InstituteLehrstuhl für Experimentalphysik I
Homepagewww.florian-rehfeldt.de

Host during sponsorship

Prof. Dr. Dennis DischerDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania (UPenn), Philadelphia
Start of initial sponsorship01/01/2007

Programme(s)

2006Feodor Lynen Research Fellowship Programme

Publications (partial selection)

2024Höllring, Kevin and Nuić, Lovro and Rogić, Luka and Kaliman, Sara and Gehrer, Simone and Wollnik, Carina and Rehfeldt, Florian and Hubert, Maxime and Smith, Ana-Sunčana: Capturing the mechanosensitivity of cell proliferation in models of epithelium. In: Proceedings of the National Academy of Sciences, 121, 2024, e2308126121
2024Speckner, Konstantin and Rehfeldt, Florian and Weiss, Matthias: Intermittent subdiffusion of short nuclear actin rods due to interactions with chromatin. In: Physical Review E, 110, 2024, 014406
2024Strake, Matthias and Fischer-Wedi, Charlotte V. and Khattab, Mohammed H. and Lauermann, Peer and Wollnik, Carina and Stanischa, Christina and Hoerauf, Hans and Rehfeldt, Florian and van Oterendorp, Christian: The influence of polyacrylamide gel substrate elasticity on primary cultures of rat retinal ganglion cells. In: Experimental Eye Research, 249, 2024, 110116
2023Jayachandran, Christina and Ghosh, Arindam and Prabhune, Meenakshi and Bath, Jonathan and Turberfield, Andrew J. and Hauke, Lara and Enderlein, Jörg and Rehfeldt, Florian and Schmidt, Christoph F.: DNA-Based Optical Sensors for Forces in Cytoskeletal Networks. In: ACS Applied Nano Materials, 6, 2023, 15455-15464
2023Hauke, Lara and Primeßnig, Andreas and Eltzner, Benjamin and Radwitz, Jennifer and Huckemann, Stefan F. and Rehfeldt, Florian: FilamentSensor 2.0: An open-source modular toolbox for 2D/3D cytoskeletal filament tracking. In: PLOS ONE, 18, 2023, e0279336
2023Hauke, Lara and Isbaner, Sebastian and Ghosh, Arindam and Guido, Isabella and Turco, Laura and Chizhik, Alexey I. and Gregor, Ingo and Karedla, Narain and Rehfeldt, Florian and Enderlein, Jörg: Metal-Induced Energy Transfer (MIET) for Live-Cell Imaging with Fluorescent Proteins. In: ACS Nano, 17, 2023, 8242-8251
2023Rehfeldt, Florian and Weiss, Matthias: The random walker's toolbox for analyzing single-particle tracking data. In: Soft Matter, 2023,
2021Hauke, Lara and Narasimhan, Shwetha and Primeßnig, Andreas and Kaverina, Irina and Rehfeldt, Florian: A Focal Adhesion Filament Cross-correlation Kit for fast, automated segmentation and correlation of focal adhesions and actin stress fibers in cells. In: PLOS ONE, 16, 2021, e0250749
2021dos Santos, A. and Cook, A. W. and Gough, R. E. and Schilling, M. and Olszok, N. A. and Brown, I. and Wang, L. and Aaron, J. and Martin-Fernandez, M. L. and Rehfeldt, F. and Toseland, C. P.: DNA damage alters nuclear mechanics through chromatin reorganization. In: Nucleic Acids Research, 49, 2021, 340-353
2021Pang, Bo and Liu, Huan and Rehfeldt, Florian and Zhang, Kai: High internal phase Pickering emulsions stabilized by dialdehyde amylopectin/chitosan complex nanoparticles. In: Carbohydrate Polymers, 258, 2021, 117655
2021Kaliman, Sara and Hubert, Maxime and Wollnik, Carina and Nuić, Lovro and Vurnek, Damir and Gehrer, Simone and Lovrić, Jakov and Dudziak, Diana and Rehfeldt, Florian and Smith, Ana-Sunčana: Mechanical Regulation of Epithelial Tissue Homeostasis. In: Physical Review X, 11, 2021, 031029
2020Pang, Bo and Zhang, Hua and Schilling, Martin and Liu, Huan and Wang, Xiaojie and Rehfeldt, Florian and Zhang, Kai: High-Internal-Phase Pickering Emulsions Stabilized by Polymeric Dialdehyde Cellulose-Based Nanoparticles. In: ACS Sustainable Chemistry & Engineering, 8, 2020, 7371-7379
2020Gortari, Antu Nehuen and Bouchoule, Sophie and Cambril, Edmond and Cattoni, Andrea and Hauke, Lara and Enderlein, Jörg and Rehfeldt, Florian and Yacomotti, Alejandro: Metasurface-based total internal reflection microscopy. In: Biomedical Optics Express, 11, 2020, 1967-1976
2019Schlick, Susanne F. and Spreckelsen, Florian and Tiburcy, Malte and Iyer, Lavanya M. and Meyer, Tim and Zelarayan, Laura C. and Luther, Stefan and Parlitz, Ulrich and Zimmermann, Wolfram-Hubertus and Rehfeldt, Florian: Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium. In: Progress in Biophysics and Molecular Biology, 144, 2019, 51-60
2019Erpenbeck, Luise and Gruhn, Antonia Luise and Kudryasheva, Galina and Günay, Gökhan and Meyer, Daniel and Busse, Julia and Neubert, Elsa and Schön, Michael P. and Rehfeldt, Florian and Kruss, Sebastian: Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation. In: Frontiers in Immunology, 10, 2019,
2019Brown, Peter and Consortium, RELISH and Zhou, Yaoqi: Large expert-curated database for benchmarking document similarity detection in biomedical literature search. In: Database, 2019, 2019,
2019Gottschalk, Hanna M. and Wecker, Thomas and Khattab, Mohammed H. and Fischer, Charlotte V. and Callizo, Josep and Rehfeldt, Florian and Lubjuhn, Roswitha and Russmann, Christoph and Hoerauf, Hans and van Oterendorp, Christian: Lipid Emulsion–Based OCT Angiography for Ex Vivo Imaging of the Aqueous Outflow TractLipid Emulsion-Based OCT Angiography. In: Investigative Ophthalmology & Visual Science, 60, 2019, 397-406
2019Huang, Heqin and Wang, Xiaojie and Yu, Jinchao and Chen, Ye and Ji, Hong and Zhang, Yumei and Rehfeldt, Florian and Wang, Yong and Zhang, Kai: Liquid-Behaviors-Assisted Fabrication of Multidimensional Birefringent Materials from Dynamic Hybrid Hydrogels. In: ACS Nano, 13, 2019, 3867-3874
2019Wang, Xiaojie and Huang, Heqin and Liu, Huan and Rehfeldt, Florian and Wang, Xiaohui and Zhang, Kai: Multi-Responsive Bilayer Hydrogel Actuators with Programmable and Precisely Tunable Motions. In: Macromolecular Chemistry and Physics, 220, 2019, 1800562
2019Delsing, Per and Cleland, Andrew N. and Schuetz, Martin J. A. and Knörzer, Johannes and Giedke, Géza and Cirac, J. Ignacio and Srinivasan, Kartik and Wu, Marcelo and Balram, Krishna Coimbatore and Bäuerle, Christopher and Meunier, Tristan and Ford, Christopher J. B. and Santos, Paulo V. and Cerda-Méndez, Edgar and Wang, Hailin and Krenner, Hubert J. and Nysten, Emeline D. S. and Weiß, Matthias and Nash, Geoff R. and Thevenard, Laura and Gourdon, Catherine and Rovillain, Pauline and Marangolo, Max and Duquesne, Jean-Yves and Fischerauer, Gerhard and Ruile, Werner and Reiner, Alexander and Paschke, Ben and Denysenko, Dmytro and Volkmer, Dirk and Wixforth, Achim and Bruus, Henrik and Wiklund, Martin and Reboud, Julien and Cooper, Jonathan M. and Fu, YongQing and Brugger, Manuel S. and Rehfeldt, Florian and Westerhausen, Christoph: The 2019 surface acoustic waves roadmap. In: Journal of Physics D: Applied Physics, 52, 2019, 353001
2019Huang, Heqin and Yang, Yang and Wang, Xiaojie and Rehfeldt, Florian and Zhang, Kai: Thermoresponsive Water Transportation in Dually Electrostatically Crosslinked Nanocomposite Hydrogels. In: Macromolecular Rapid Communications, 40, 2019, 1900317
2018Chizhik, Anna M. and Wollnik, Carina and Ruhlandt, Daja and Karedla, Narain and Chizhik, Alexey I. and Hauke, Lara and Hähnel, Dirk and Gregor, Ingo and Enderlein, Jörg and Rehfeldt, Florian: Dual-color metal-induced and Förster resonance energy transfer for cell nanoscopy. In: Molecular Biology of the Cell, 29, 2018, 846-851
2018Huang, Heqin and Wang, Xiaojie and Rehfeldt, Florian and Zhang, Kai: Dually Heterogeneous Hydrogels via Dynamic and Supramolecular Cross-Links Tuning Discontinuous Spatial Ruptures. In: ACS Sustainable Chemistry & Engineering, 6, 2018, 4294-4301
2018Narayanan, Pratibha and Hütte, Meike and Kudryasheva, Galina and Taberner, Francisco J. and Lechner, Stefan G. and Rehfeldt, Florian and Gomez-Varela, David and Schmidt, Manuela: Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons. In: eLife, 7, 2018, e32346
2018Franz, Jonas and Grünebaum, Jonas and Schäfer, Marcus and Mulac, Dennis and Rehfeldt, Florian and Langer, Klaus and Kramer, Armin and Riethmüller, Christoph: Rhombic organization of microvilli domains found in a cell model of the human intestine. In: PLOS ONE, 13, 2018, e0189970
2018Ando, Toshio and Bhamidimarri, Satya Prathyusha and Brending, Niklas and Colin-York, H. and Collinson, Lucy and De Jonge, Niels and de Pablo, P. J. and Debroye, Elke and Eggeling, Christian and Franck, Christian and Fritzsche, Marco and Gerritsen, Hans and Giepmans, Ben N. G. and Grunewald, Kay and Hofkens, Johan and Hoogenboom, Jacob P. and Janssen, Kris P. F. and Kaufmann, Rainer and Klumpermann, Judith and Kurniawan, Nyoman and Kusch, Jana and Liv, Nalan and Parekh, Viha and Peckys, Diana B. and Rehfeldt, Florian and Reutens, David C. and Roeffaers, Maarten B. J. and Salditt, Tim and Schaap, Iwan A. T. and Schwarz, Ulrich S. and Verkade, Paul and Vogel, Michael W. and Wagner, Richard and Winterhalter, Mathias and Yuan, Haifeng and Zifarelli, Giovanni: The 2018 correlative microscopy techniques roadmap. In: Journal of Physics D: Applied Physics, 51, 2018, 443001
2018Heidemann, Knut M. and Sageman-Furnas, Andrew O. and Sharma, Abhinav and Rehfeldt, Florian and Schmidt, Christoph F. and Wardetzky, Max: Topology determines force distributions in one-dimensional random spring networks. In: Physical Review E, 97, 2018, 022306
2017Bernhardt, Marten and Nicolas, Jan D. and Eckermann, Marina and Eltzner, Benjamin and Rehfeldt, Florian and Salditt, Tim: Anisotropic x-ray scattering and orientation fields in cardiac tissue cells. In: New Journal of Physics, 19, 2017, 013012
2017Buxboim, Amnon and Irianto, Jerome and Swift, Joe and Athirasala, Avathamsa and Shin, Jae-Won and Rehfeldt, Florian and Discher, Dennis E.: Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes. In: Molecular Biology of the Cell, 28, 2017, 3333-3348
2017Benes, Viktor and Vecera, Jakub and Eltzner, Benjamin and Wollnik, Carina and Rehfeldt, Florian and Kralova, Veronika and Huckemann, Stephan: Estimation of Parameters in a Planar Segment Process with a Biological Application. In: Image Analysis & Stereology, 36, 2017, 25
2017Prabhune, Meenakshi and Rehfeldt, Florian and Schmidt, Christoph F.: Molecular force sensors to measure stress in cells. In: Journal of Physics D: Applied Physics, 50, 2017, 233001
2017Rehfeldt, Florian and Schmidt, Christoph F.: Physical probing of cells. In: Journal of Physics D: Applied Physics, 50, 2017, 463001
2017Huang, Heqin and Wang, Yonggui and Wang, Xiaojie and Rehfeldt, Florian and Zhang, Kai: Robust Heterogeneous Hydrogels with Dynamic Nanocrystal–Polymer Interface. In: Macromolecular Rapid Communications, 38, 2017, 1600810
2016Kaliman, Sara and Jayachandran, Christina and Rehfeldt, Florian and Smith, Ana-Sunčana: Limits of Applicability of the Voronoi Tessellation Determined by Centers of Cell Nuclei to Epithelium Morphology. In: Frontiers in Physiology, 7, 2016,
2016Prabhune, Meenakshi and von Roden, Kerstin and Rehfeldt, Florian and Schmidt, Christoph F.: Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. In: PLOS ONE, 11, 2016, e0161623
2016Huckemann, Stephan and Kim, Kwang-Rae and Munk, Axel and Rehfeldt, Florian and Sommerfeld, Max and Weickert, Joachim and Wollnik, Carina: The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation. In: Bernoulli, 22, 2016, 2113-2142
2016Bernhardt, Marten and Priebe, Marius and Osterhoff, Markus and Wollnik, Carina and Diaz, Ana and Salditt, Tim and Rehfeldt, Florian: X-Ray Micro- and Nanodiffraction Imaging on Human Mesenchymal Stem Cells and Differentiated Cells. In: Biophysical Journal, 110, 2016, 680-690
2015Heidemann, Knut M. and Sharma, Abhinav and Rehfeldt, Florian and Schmidt, Christoph F. and Wardetzky, Max: Elasticity of 3D networks with rigid filaments and compliant crosslinks. In: Soft Matter, 11, 2015, 343-354
2015Schlosser, Florian and Rehfeldt, Florian and Schmidt, Christoph F.: Force fluctuations in three-dimensional suspended fibroblasts. In: Philosophical Transactions of the Royal Society B: Biological Sciences, 370, 2015,
2015Paluch, Ewa K. and Nelson, Celeste M. and Biais, Nicolas and Fabry, Ben and Moeller, Jens and Pruitt, Beth L. and Wollnik, Carina and Kudryasheva, Galina and Rehfeldt, Florian and Federle, Walter: Mechanotransduction: use the force(s). In: BMC Biology, 13, 2015, 47
2015Eltzner, Benjamin and Wollnik, Carina and Gottschlich, Carsten and Huckemann, Stephan and Rehfeldt, Florian: The Filament Sensor for Near Real-Time Detection of Cytoskeletal Fiber Structures. In: PLOS ONE, 10, 2015, e0126346
2014Shin, Jae-Won and Buxboim, Amnon and Spinler, Kyle R and Swift, Joe and Christian, David A and Hunter, Christopher A and Léon, Catherine and Gachet, Christian and Dingal, P. C. Dave P and Ivanovska, Irena L and Rehfeldt, Florian and Chasis, Joel Anne and Discher, Dennis E: Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells. In: Cell Stem Cell, 14, 2014, 81-93
2014Sandmann, Rabea and Henriques, Sarah Schwarz G. and Rehfeldt, Florian and Koster, Sarah: Micro-topography influences blood platelet spreading. In: Soft Matter, 10, 2014, 2365-2371
2013Swift, Joe and Ivanovska, Irena L. and Buxboim, Amnon and Harada, Takamasa and Dingal, P. C. Dave P. and Pinter, Joel and Pajerowski, J. David and Spinler, Kyle R. and Shin, Jae-Won and Tewari, Manorama and Rehfeldt, Florian and Speicher, David W. and Discher, Dennis E.: Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation. In: Science, 341, 2013,
2012Rehfeldt, Florian and Brown, Andre E. X. and Raab, Matthew and Cai, Shenshen and Zajac, Allison L. and Zemel, Assaf and Discher, Dennis E.: Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells. In: Integrative Biology, 4, 2012, 422-430
2012Florian Rehfeldt, André E. X. Brown Matthew Raab Shenshen Cai Allison L. Zajac Assaf Zemel and Dennis E. Discher: Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells . In: Integrative Biology, 2012, 422-430
2010Zemel, Assaf and Rehfeldt, Florian and Brown, Andre E. X. and Discher, Dennis E. and Safran, Samuel A.: Cell shape, spreading symmetry, and the polarization of stress-fibers in cells. In: Journal of Physics: Condensed Matter, 22, 2010, 194110
2010Assaf Zemel, Florian Rehfeldt, Andre E. X. Brown,Dennis E. Discher, and Samuel A. Safran: Optimal matrix rigidity for stress-fibre polarization in stem cells. In: Nature Physics, 6, 2010, 468-473
2009Schneck, Emanuel and Oliveira, Rafael G. and Rehfeldt, Florian and Demé, Bruno and Brandenburg, Klaus and Seydel, Ulrich and Tanaka, Motomu: Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering. In: Physical Review E, 80, 2009, 041929
2008Schneck, Emanuel and Rehfeldt, Florian and Oliveira, Rafael G. and Gege, Christian and Demé, Bruno and Tanaka, Motomu: Modulation of intermembrane interaction and bending rigidity of biomembrane models via carbohydrates investigated by specular and off-specular neutron scattering. In: Physical Review E, 78, 2008, 061924
2008Rossetti, Fernanda F. and Panagiotou, Panteleimon and Rehfeldt, Florian and Schneck, Emanuel and Dommach, Martin and Funari, Sergio S. and Timmann, Andreas and Müller-Buschbaum, Peter and Tanaka, Motomu: Structures of regenerated cellulose films revealed by grazing incidence small-angle x-ray scattering. In: Biointerphases, 3, 2008, 117-127
2007Rehfeldt, Florian and Discher, Dennis E.: Cell dipoles feel their way. In: Nature Physics, 3, 2007, 592
2007Rehfeldt, Florian and Engler, Adam J. and Eckhardt, Adam and Ahmed, Fariyal and Discher, Dennis E.: Cell responses to the mechanochemical microenvironment—Implications for regenerative medicine and drug delivery. In: Advanced Drug Delivery Reviews, 59, 2007, 1329-1339
2006Rehfeldt, Florian and Steitz, Roland and Armes, Steven P. and von Klitzing, Regine and Gast, Alice P. and Tanaka, Motomu: Reversible Activation of Diblock Copolymer Monolayers at the Interface by pH Modulation, 2:  Membrane Interactions at the Solid/Liquid Interface. In: The Journal of Physical Chemistry B, 110, 2006, 9177-9182
2005Tanaka, Motomu and Rehfeldt, Florian and Schneider, Matthias F. and Gege, Christian and Schmidt, Richard R. and Funari, Sérgio S.: Oligomer‐to‐Polymer Transition in Short Ethylene Glycol Chains Connected to Mobile Hydrophobic Anchors. In: ChemPhysChem, 6, 2005, 101-109
2005Tanaka, Motomu and Rehfeldt, Florian and Schneider, Matthias F. and Mathe, Gerald and Albersdörfer, Antero and Neumaier, Klaus R. and Purrucker, Oliver and Sackmann, Erich: Wetting and dewetting of extracellular matrix and glycocalix models. In: Journal of Physics: Condensed Matter, 17, 2005, S649
2004Tanaka, Motomu and Wong, Amy P. and Rehfeldt, Florian and Tutus, Murat and Kaufmann, Stefan: Selective Deposition of Native Cell Membranes on Biocompatible Micropatterns. In: Journal of the American Chemical Society, 126, 2004, 3257-3260
2004Wong, John E. and Rehfeldt, Florian and Hänni, Peter and Tanaka, Motomu and Klitzing, Regine v: Swelling Behavior of Polyelectrolyte Multilayers in Saturated Water Vapor. In: Macromolecules, 37, 2004, 7285-7289
2003Rehfeldt, Florian and Tanaka, Motomu: Hydration Forces in Ultrathin Films of Cellulose. In: Langmuir, 19, 2003, 1467-1473
2002Rehfeldt, Florian and Tanaka, Motomu and Pagnoni, Lorena and Jordan, Rainer: Static and Dynamic Swelling of Grafted Poly(2-alkyl-2-oxazoline)s. In: Langmuir, 18, 2002, 4908-4914
1997Niederfellner, J. and Lenoir, D. and Matuschek, G. and Rehfeldt, F. and Utschick, H. and Brüggemann, R.: Description of Vapour Pressures of Polycyclic Aromatic Compounds by Graph Theoretical Indices. In: Quantitative Structure-Activity Relationships, 16, 1997, 38-48