Prof. Dr. Corette J. Wierenga

Profile

Academic positionFull Professor
Research fieldsBiological Psychology and Cognitive Neuroscience,Molecular Biology and Physiology of Neurons and Glial Cells,Experimental Models for the Understanding of Nervous System Diseases
Keywordssynapse formation, synaptic plasticity, inhibitory synapses, two-photon imaging, organotypic cultures

Current contact address

CountryNetherlands
CityNijmegen
InstitutionRadboud University
InstituteDonders Institute for Brain, Cognition and Behaviour
Homepagehttps://www.ru.nl/personen/wierenga-c

Host during sponsorship

Prof. Dr. Tobias BonhoefferLife Science Campus Martinsried, Max-Planck-Institut für biologische Intelligenz, Planegg-Martinsried
Start of initial sponsorship01/05/2006

Programme(s)

2006Humboldt Research Fellowship Programme

Publications (partial selection)

2025S. Zehra H. Kazmi and Corette J. Wierenga: Deep cortical layers are more vulnerable in Alzheimer’s disease. In: Neuron, 113, 2025, 2218-2220
2025Sam de Kater, Lotte J. Herstel and Corette J. Wierenga: Monitoring Changes in Intracellular Chloride Levels Using the FRET-Based SuperClomeleon Sensor in Organotypic Hippocampal Slices. In: Bio-protocol, 15, 2025, e5229
2023Peerboom C, De Kater S, Jonker N, Rieter MPJM, Wijne T, Wierenga CJ Delaying the GABA shift indirectly affects membrane properties in the developing hippocampus. In: Journal of Neuroscience, 43, 2023, 5483-5500
2023Peerboom, Carlijn and de Kater, Sam and Jonker, Nikki and Rieter, Marijn PJM and Wijne, Tessel and Wierenga, Corette J: Delaying the GABA shift indirectly affects membrane properties in the developing hippocampus. In: Journal of Neuroscience, 43, 2023, 5483--5500
2023Boerma, Tessel and Ter Haar, Sita and Ganga, Rachida and Wijnen, Frank and Blom, Elma and Wierenga, Corette J: What risk factors for Developmental Language Disorder can tell us about the neurobiological mechanisms of language development. In: Neuroscience \& Biobehavioral Reviews, 2023, 105398
2022Bijlsma, Ate and Omrani, Azar and Spoelder, Marcia and Verharen, Jeroen PH and Bauer, Lisa and Cornelis, Cosette and de Zwart, Beleke and van Dorland, Ren{\'e} and Vanderschuren, Louk JMJ and Wierenga, Corette J: Social play behavior is critical for the development of prefrontal inhibitory synapses and cognitive flexibility in rats. In: Journal of Neuroscience, 42, 2022, 8716--8728
2022Herstel, Lotte J and Peerboom, Carlijn and Uijtewaal, Sten and Selemangel, Dunya and Karst, Henk and Wierenga, Corette J: Using SuperClomeleon to measure changes in intracellular chloride during development and after early life stress. In: eneuro, 9, 2022,
2022Maffei, Arianna and Chiappalone, Michela and Fattore, Liana and Torres, Elizabeth B and Tremblay, Marie-{\`E}ve and Wierenga, Corette J: Women in neuroscience. In: Frontiers in Integrative Neuroscience, 16, 2022, 1032506
2021Ruiter, Marvin and Lützkendorf, Christine and Liang, Jian and Wierenga, Corette J: Amyloid-$\beta$ oligomers induce only mild changes to inhibitory bouton dynamics. In: Journal of Alzheimer's Disease Reports, 5, 2021, 153--160
2021Liang, Jian and Kruijssen, Dennis LH and Verschuuren, Aniek CJ and Voesenek, Bas JB and Benavides, Feline FW and Gonzalez, Maria S{\'a}ez and Ruiter, Marvin and Wierenga, Corette J: Axonal CB1 receptors mediate inhibitory bouton formation via cAMP increase and PKA. In: Journal of Neuroscience, 41, 2021, 8279--8296
2021Lindhout, Feline W and Portegies, Sybren and Kooistra, Robbelien and Herstel, Lotte J and Stucchi, Riccardo and Hummel, Jessica JA and Scheefhals, Nicky and Katrukha, Eugene A and Altelaar, Maarten and MacGillavry, Harold D and others: Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons. In: The EMBO journal, 40, 2021, e106798
2021Herstel, Lotte J and Wierenga, Corette J: Network control through coordinated inhibition. In: Current Opinion in Neurobiology, 67, 2021, 34--41
2021Homberg, Judith R and Adan, Roger AH and Alenina, Natalia and Asiminas, Antonis and Bader, Michael and Beckers, Tom and Begg, Denovan P and Blokland, Arjan and Burger, Marilise E and van Dijk, Gertjan and others: The continued need for animals to advance brain research. In: Neuron, 109, 2021, 2374--2379
2021Peerboom, Carlijn and Wierenga, Corette J: The postnatal GABA shift: a developmental perspective. In: Neuroscience \& Biobehavioral Reviews, 124, 2021, 179--192
2020Genzel, Lisa and Adan, Roger and Berns, Anton and van den Beucken, Jeroen JJP and Blokland, Arjan and Boddeke, Erik HWGM and Bogers, Willy M and Bontrop, Ronald and Bulthuis, R and Bousema, Teun and others: How the COVID-19 pandemic highlights the necessity of animal research. In: Current Biology, 30, 2020, R1014--R1018
2020Lindhout, Feline W and Kooistra, Robbelien and Portegies, Sybren and Herstel, Lotte J and Stucchi, Riccardo and Snoek, Basten L and Altelaar, AF Maarten and MacGillavry, Harold D and Wierenga, Corette J and Hoogenraad, Casper C: Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons. In: Elife, 9, 2020, e58124
2020Ruiter, Marvin and Herstel, Lotte J and Wierenga, Corette J: Reduction of dendritic inhibition in CA1 pyramidal neurons in amyloidosis models of early Alzheimer?s disease. In: Journal of Alzheimer's Disease, 78, 2020, 951--964
2019Hu, Hai Yin and Kruijssen, Dennis LH and Frias, C{\'a}tia P and R{\'o}zsa, Bal{\'a}zs and Hoogenraad, Casper C and Wierenga, Corette J: Endocannabinoid signaling mediates local dendritic coordination between excitatory and inhibitory synapses. In: Cell reports, 27, 2019, 666--675
2019Frias, C{\'a}tia P and Liang, Jian and Bresser, Tom and Scheefhals, Lisa and van Kesteren, Matthijs and van Dorland, Ren{\'e} and Hu, Hai Yin and Bodzeta, Anna and en Henegouwen, Paul MP van Bergen and Hoogenraad, Casper C and others: Semaphorin4D induces inhibitory synapse formation by rapid stabilization of presynaptic boutons via MET coactivation. In: Journal of Neuroscience, 39, 2019, 4221--4237
2019Kruijssen, Dennis LH and Wierenga, Corette J: Single synapse LTP: a matter of context?. In: Frontiers in cellular neuroscience, 13, 2019, 496
2018Niculescu, Dragos and Michaelsen-Preusse, Kristin and Güner, Ülkü and van Dorland, Ren{\'e} and Wierenga, Corette J and Lohmann, Christian: A BDNF-mediated push-pull plasticity mechanism for synaptic clustering. In: Cell reports, 24, 2018, 2063--2074
2018Schätzle, Philipp and da Silva, Marta Esteves and Tas, Roderick P and Katrukha, Eugene A and Hu, Hai Yin and Wierenga, Corette J and Kapitein, Lukas C and Hoogenraad, Casper C: Activity-dependent actin remodeling at the base of dendritic spines promotes microtubule entry. In: Current Biology, 28, 2018, 2081--2093
2018Schulte, Joran T and Wierenga, Corette J and Bruining, Hilgo: Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions. In: Neuroscience \& Biobehavioral Reviews, 90, 2018, 260--271
2018Nijhof, Sanne L and Vinkers, Christiaan H and van Geelen, Stefan M and Duijff, Sasja N and Achterberg, EJ Marijke and Van Der Net, Janjaap and Veltkamp, Remco C and Grootenhuis, Martha A and van de Putte, Elise M and Hillegers, Manon HJ and others: Healthy play, better coping: The importance of play for the development of children in health and disease. In: Neuroscience \& Biobehavioral Reviews, 95, 2018, 421--429
2017Wierenga, Corette J: Live imaging of inhibitory axons: Synapse formation as a dynamic trial-and-error process. In: Brain research bulletin, 129, 2017, 43--49
2017Lenz, M and Galanis, C and Müller-Dahlhaus, F and Opitz, A and Wierenga, CJ and Szab{\'o}, G and Ziemann, U and Deller, T and Funke, K and Vlachos, A: P292 10 Hz rTMS induces long-term depression of GABAergic neurotransmission. In: Clinical Neurophysiology, 128, 2017, e152--e153
2016Harschnitz, Oliver and van den Berg, Leonard H and Johansen, Lill Eva and Jansen, Marc D and Kling, Sandra and Vieira de S{\'a}, Renata and Vlam, Lotte and van Rheenen, Wouter and Karst, Henk and Wierenga, Corette J and others: Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell--derived model. In: Annals of Neurology, 80, 2016, 71--88
2016Kellner, Yves and Fricke, Steffen and Kramer, Stella and Iobbi, Cristina and Wierenga, Corette J and Schwab, Martin E and Korte, Martin and Zagrebelsky, Marta: Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. In: Hippocampus, 26, 2016, 816--831
2016Lenz, Maximilian and Galanis, Christos and Müller-Dahlhaus, Florian and Opitz, Alexander and Wierenga, Corette J and Szab{\'o}, G{\'a}bor and Ziemann, Ulf and Deller, Thomas and Funke, Klaus and Vlachos, Andreas: Repetitive magnetic stimulation induces plasticity of inhibitory synapses. In: Nature communications, 7, 2016, 10020
2015da Silva, Marta Esteves and Adrian, Max and Schätzle, Philipp and Lipka, Joanna and Watanabe, Takuya and Cho, Sukhee and Futai, Kensuke and Wierenga, Corette J and Kapitein, Lukas C and Hoogenraad, Casper C: Positioning of AMPA receptor-containing endosomes regulates synapse architecture. In: Cell reports, 13, 2015, 933--943
2015Müllner, Fiona E and Wierenga, Corette J and Bonhoeffer, Tobias: Precision of inhibition: dendritic inhibition by individual GABAergic synapses on hippocampal pyramidal cells is confined in space and time. In: Neuron, 87, 2015, 576--589
2014Adrian, Max and Kusters, Remy and Wierenga, Corette J and Storm, Cornelis and Hoogenraad, Casper C and Kapitein, Lukas C: Barriers in the brain: resolving dendritic spine morphology and compartmentalization. In: Frontiers in neuroanatomy, 8, 2014, 142
2014Gomis-Rüth, Susana and Stiess, Michael and Wierenga, Corette J and Meyn, Liane and Bradke, Frank: Single-cell axotomy of cultured hippocampal neurons integrated in neuronal circuits. In: Nature protocols, 9, 2014, 1028--1037
2013Frias, Cátia P and Wierenga, Corette J: Activity-dependent adaptations in inhibitory axons. In: Frontiers in Cellular neuroscience, 7, 2013,
2013Vogels, Tim P and Froemke, Robert C and Doyon, Nicolas and Gilson, Matthieu and Haas, Julie S and Liu, Robert and Maffei, Arianna and Miller, Paul and Wierenga, CJ and Woodin, Melanie A and others: Inhibitory synaptic plasticity: spike timing-dependence and putative network function. In: Frontiers in neural circuits, 7, 2013, 119
2013Schuemann, Anne and Klawiter, Agnieszka and Bonhoeffer, Tobias and Wierenga, Corette J: Structural plasticity of GABAergic axons is regulated by network activity and GABAA receptor activation. In: Frontiers in neural circuits, 7, 2013, 113
2011Keck, Tara and Scheuss, Volker and Jacobsen, R Irene and Wierenga, Corette J and Eysel, Ulf T and Bonhoeffer, Tobias and Hübener, Mark: Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex. In: Neuron, 71, 2011, 869--882
2010Wierenga, Corette J and Müllner, Fiona E and Rinke, Ilka and Keck, Tara and Stein, Valentin and Bonhoeffer, Tobias: Molecular and electrophysiological characterization of GFP-expressing CA1 interneurons in GAD65-GFP mice. In: PloS one, 5, 2010, e15915
2008Omrani, Azar and Bijlsma, Ate and Spoelder, Marcia and Verharen, Jeroen PH and Bauer, Lisa and Cornelis, Cosette and van Dorland, Ren{\'e} and Vanderschuren, Louk JMJ and Wierenga, Corette J: An altered cognitive strategy associated with reduction of synaptic inhibition in. In: Behav. Brain Res, 190, 2008, 85--96
2008Wierenga, Corette J and Becker, Nadine and Bonhoeffer, Tobias: GABAergic synapses are formed without the involvement of dendritic protrusions. In: Nature neuroscience, 11, 2008, 1044--1052
2008Becker, Nadine and Wierenga, Corette J and Fonseca, Rosalina and Bonhoeffer, Tobias and Nägerl, U Valentin: LTD induction causes morphological changes of presynaptic boutons and reduces their contacts with spines. In: Neuron, 60, 2008, 590--597
2008Gomis-Rüth, Susana and Wierenga, Corette J and Bradke, Frank: Plasticity of polarization: changing dendrites into axons in neurons integrated in neuronal circuits. In: Current biology, 18, 2008, 992--1000
2006Wierenga, Corette J and Walsh, Michael F and Turrigiano, Gina G: Temporal regulation of the expression locus of homeostatic plasticity. In: Journal of neurophysiology, 96, 2006, 2127--2133
2006Wierenga CJ, Walsh MF, Turrigiano GG: Temporal regulation of the expression locus of homeostatic plasticity.. In: Journal of Neurophysiology, 96, 2006, 2127--2133
2005Wierenga, Corette J and Ibata, Keiji and Turrigiano, Gina G: Postsynaptic expression of homeostatic plasticity at neocortical synapses. In: Journal of Neuroscience, 25, 2005, 2895--2905
2003Wierenga, Corette J and Wadman, Wytse J: Excitatory inputs to CA1 interneurons show selective synaptic dynamics. In: Journal of neurophysiology, 90, 2003, 811--821
2003Wierenga, CJ and Wadman, WJ: Functional relation between interneuron input and population activity in the rat hippocampal cornu ammonis 1 area. In: Neuroscience, 118, 2003, 1129--1139
1999Wierenga, Corette J and Wadman, Wytse J: Miniature inhibitory postsynaptic currents in CA1 pyramidal neurons after kindling epileptogenesis. In: Journal of Neurophysiology, 82, 1999, 1352--1362
1999Kortekaas, Ph and Wierenga, CJ and Wadman, WJ: Spatial redistribution of the low voltage activated calcium current in the developing rat pyramidal CA1 neurons. In: Plügers Archiv, 438, 1999,