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Profile
| Academic position | Associate Professor, Senior Lecturer, Reader |
|---|---|
| Research fields | Cell Biology,General Genetics, Functional Genome Research |
| Keywords | cardiac development, cytokinesis, heart, zebrafish, regeneration |
| Honours and awards | 2018: Offer W3 Professor for Developmental Biology, Konstanz (refused) 2015: German representative for Molecular Biology, German-American Kavli Frontiers of Science symposium 2012: Julius-Klob-Publication-Award, German Cardiac Society (T. Novoyatleva) 2007: Selected for TV series: „Visionaries of Germany“, 3Sat, nano 2006: Sofja Kovalevskaja Award 2005: Children’s Hospital (Boston) Research Day Award 2001: Trainee Abstract Award, American Heart Association, Council on Basic Cardiovascular Sciences |
Current contact address
| Country | Germany |
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| City | Erlangen |
| Institution | Friedrich-Alexander-Universität Erlangen-Nürnberg |
| Institute | Pathologisches Institut |
| Homepage | http://www.nephropathologie.uk-erlangen.de/en/ag-engel-exp-renal-and-cardiovascular-research/ |
Host during sponsorship
| Prof. Dr. Dr. Thomas Braun | Abteilung I: Entwicklung und Umbau des Herzens, Max-Planck-Institut für Herz- und Lungenforschung, Bad Nauheim |
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| Start of initial sponsorship | 01/12/2006 |
Programme(s)
| 2006 | Sofja Kovalevskaja Award Programme |
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Nominator's project description
| The human heart is a unique organ in the true sense of the word: adult heart cells are unable to divide. If they die off as a result of a heart attack, for instance, the tissue cannot rebuild itself. Felix Engel is searching for a way of encouraging adult heart cells to divide - a capacity inherent in youthful cells, but one which they lose shortly after birth. As Felix Engel and his colleagues discovered, responsibility for this lies with a protein. If it is blocked, the cell regains its capacity to divide. What has worked in experiments on animals is now supposed to be used to treat humans successfully and thus be developed as an alternative to the controversial treatment with stem cells. |
Publications (partial selection)
| 2013 | Novoyatleva T, Schymura Y, Janssen W, Strobl F, Swiercz JM, Patra C, Posern G, Wietelmann A, Zheng TS, Schermuly RT, Engel FB.: Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction.. In: Basic Res Cardiol. , 2013, 325 |
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| 2013 | Balaji Samikannu, Chunguang Chen, Neelam Lingwal, Manju Padmasekar Felix B. Engel, Thomas Linn: Dipeptidyl Peptidase IV inhibition activates CREB and improves islet vascularization through VEGF-A/VEGFR-2 signaling pathway.. In: PLoS One, 2013, |
| 2013 | Amit Mogha, Andrew E. Benesh, Chinmoy Patra, Felix B. Engel, Torsten Schöneberg, Ines Liebscher, Kelly R. Monk : Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. . In: J Neurosci, 2013, 17986-17994 |
| 2013 | Hideki Uosaki, Ajit Magadum, Kinya Seo, Hiroyuki Fukushima, Ayako Takeuchi, Yasuaki Nakagawa, Kara White Moyes, Genta Narazaki, Koichiro Kuwahara, Michael Laflamme, SatoshiMatsuoka, Norio Nakatsuji, Kazuwa Nakao, Chulan Kwon, David A. Kass, Felix B. Engel and Jun K.Yamashita: Identification of Chemicals Inducing Cardiomyocyte Proliferation in Developmental Stage-Specific Manner with Pluripotent Stem Cells.. In: Circ Cardiovasc Genet, 2013, |
| 2013 | Chinmoy Patra, Machteld van Amerongen, Subhajit Ghosh, Filomena Ricciardi, Amna Sajjad, Tatyana Novoyatleva, Amit Mogha, Kelly Monk, Christian Mühlfeld, Felix Engel Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. . In: Proc Natl Acad Sci U S A, 2013, 16898-16903 |
| 2013 | Banani Kundu, Nicholas E. Kurland, Subia Bano, Chinmoy Patra, Felix B. Engel, Vamsi K. Yadavalli, Subhas C. Kundu : Silk proteins for biomedical applications: Bioengineering perspectives.. In: Prog Polym Sci, 2013, |
| 2013 | Tatyana Novoyatleva, Wiebke Janssen, Astrid Wietelmann, Ralph Schermuly, Felix Engel TWEAK/Fn14 axis is a positive regulator of cardiac hypertrophy. . In: Cytokine, 2013, 43-45 |
| 2013 | David Zebrowski, Felix Engel: The Cardiomyocyte Cell Cycle in Hypertrophy, Tissue Homeostasis, and Regeneration. . In: Rev Physiol Biochem Pharmacol, 2013, |
| 2012 | Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T.: Dissecting signaling and functions of adhesion G protein-coupled receptors.. In: Ann N Y Acad Sci., 2012, 1-25 |
| 2012 | Machteld van Amerongen, Felix Engel: Induction of Cardiomyocyte Proliferation. ed. Engel FB. Heart Regeneration: Stem Cells and Beyond. In: Felix Engel, Heart Regeneration: Stem Cells and Beyond.. World Scientific Publishing Company, Inc., 2012. |
| 2012 | Chinmoy Patra, Sarmistha Talukdar, Tatyana Novoyatleva, Siva R. Velagala, Christian Mühlfeld, Banani Kundu, Subhas C. Kundu, Felix B. Engel: Silk protein fibroin from Antheraea mylitta for cardiac tissue engineering.. In: Biomaterials, 2012, 2673-80 |
| 2012 | Tatyana Novoyatleva, Felix Engel: The Complexity of Organ Regeneration. . In: Felix Engel, Heart Regeneration: Stem Cells and Beyond. World Scientific Publishing Company, Inc., 2012. |
| 2012 | Chinmoy Patra; Filomena Ricciardi; Felix B. Engel: The functional properties of nephronectin: An adhesion molecule for cardiac tissue engineering.. In: Biomaterials, 2012, 4327-4335 |
| 2011 | Ferrazzi F, Engel FB, Wu E, Moseman AP, Kohane IS, Bellazzi R, Ramoni MF. Inferring cell cycle feedback regulation from gene expression data.. In: J Biomed Inform, 2011, 565-575 |
| 2011 | Patra C, Diehl F, Ferrazzi F, van Amerongen MJ, Novoyatleva T, Schaefer L, Mühlfeld C, Jungblut B, Engel FB.: Nephronectin regulates via BMP4-HAS2 signaling the differentiation of the atrio-ventricular canal in zebrafish. . In: Development, 2011, 4499-4509 |
| 2010 | Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazzi F, Böttger T, Harvey RP, Tucker PW, Engel FB. Cardiac deletion of Smyd2 is dispensable for mouse heart development.. In: PLoS ONE., 2010, e9748 |
| 2010 | Machteld J. van Amerongen, Florian Diehl, Tatyana Novoyatleva, Chinmoy Patra, Felix B. Engel: E2F4 is required for cardiomyocyte proliferation. In: Cardiovasc Res, 2010, 92-102 |
| 2010 | Tatyana Novoyatleva, Florian Diehl, Machteld J. van Amerongen, Chinmoy Patra, Fulvia Ferrazzi, Riccardo Bellazzi, Felix B. Engel: TWEAK is a positive regulator of cardiomyocyte proliferation. In: Cardiovasc Res, 2010, 681-690 |
| 2008 | van Amerongen MJ and Engel FB: Features of cardiomyocyte proliferation and its potential for cardiac regeneration.. In: J Cell Mol Med, 2008, 2233-2244 |
| 2008 | Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FWJS, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA. Hypoxia-inducible factor induces local thyroid hormone inactivation in hypoxic-ischemic disease. . In: J Clin Invest, 2008, 975-983 |
| 2006 | Engel FB, Schebesta M, Keating MT. Anillin Localization Defect in Cardiomyocyte Binucleation.. In: J Mol Cell Cardiol. , 2006, 601-612 |
| 2006 | Engel FB, Hsieh PCH, Lee RT, and Keating MT. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring and rescues function after myocardial infarction. . In: Proc Natl Acad Sci U S A. , 2006, 15546-15551 |
| 2006 | Tseng AS, Engel FB, and Keating MT. The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes.. In: Chemistry & Biology, 2006, 957-963 |
| 2006 | Schebesta M, Lien CL, Engel FB, Keating MT. Transcriptional Profiling of Caudal Fin Regeneration in Zebrafish.. In: TSW Development & Embryology., 2006, 38-54 |
| 2005 | Felix B. Engel: Cardiomyocyte proliferation: a platform for mammalian cardiac repair. In: Cell Cycle, 2005, 1360-1363 |
| 2005 | Felix B. Engel, Michael Schebesta, Mychelle T. Duong, Gang Lu, Shuxun Ren, Jeffery B. Madwed, Huiping Jiang, Yibin Wang, Mark T. Keating: p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. In: Genes Dev, 2005, 1175-1187 |
| 2004 | Oliver Gresch, Felix B. Engel, Dobrila Nesic, Thi Thai Tran, Hazel M. England, Emma S. Hickman, Ida Körner, Li Gan, Sylvia Chen, Susana Castro-Obregon, Rainer Hammermann, Jürgen Wolf, Herbert Müller-Hartmann, Michael Nix, Gregor Siebenkotten, Günter Kraus, Klaus Lun: New non-viral method for gene transfer into primary cells. In: Methods, 2004, 151-163 |
| 2004 | Ulrike Philippar, Gerhard Schratt, Christoph Dieterich, Judith M. Müller, Petra Galgoczy, Felix B. Engel, Mark T. Keating, Frank Gertler, Roland Schüle, Martin Vingron, Alfred Nordheim: The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. In: Molecular Cell, 2004, 867-880 |
| 2003 | Felix B. Engel, Ludger Hauck, Manfred Boehm, Elizabeth G. Nabel, Rainer Dietz, and Rüdiger von Harsdorf: p21(CIP1) Controls proliferating cell nuclear antigen level in adult cardiomyocytes. In: Mol Cell Biol, 2003, 555-565 |
| 1999 | Felix B. Engel, Ludger Hauck, M. Cristina Cardoso, Heinrich Leonhardt, Rainer Dietz, Rüdiger von Harsdorf: A mammalian myocardial cell-free system to study cell cycle reentry in terminally differentiated cardiomyocytes. In: Circ Res, 1999, 294-301 |