Prof. Dr. med. Beate Winner

Profile

Academic positionFull Professor
Research fieldsMolecular and Cellular Neurology and Neuropathology,Experimental Models for the Understanding of Nervous System Diseases,General Genetics, Functional Genome Research
KeywordsHuman pluripotent stem cells, Neurodegeneration, Disease modeling, Gut brain axis, Hereditäre spastische Spinalparalyse

Current contact address

CountryGermany
CityErlangen
InstitutionFriedrich-Alexander-Universität Erlangen-Nürnberg
InstituteStammzellbiologische Abteilung

Host during sponsorship

Prof. Dr. Fred H. GageLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla
Start of initial sponsorship01/08/2007

Programme(s)

2007Feodor Lynen Research Fellowship Programme

Publications (partial selection)

2011Beate Winner, Heather Melrose, Chumei Zhao, Kelly M. Hinkle, M. Yue, C. Kent, A.T. Braithwaite, S. Ogholikhan, Robert Aigner, Jürgen Winkler, M.J. Farrer, and Fred H. Gage: Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. In: Neurobiology of Disease, 2011, 706-716
2011Beate Winner, Roberto Jappelli, Samir K. Maji, Paula A. Desplats, Leah Boyer, Stefan Aigner, Claudia Hetzer, Thomas Loher, Marçal Vilar, Silvia Campioni, Christos Tzitzilonis, Alice Soragni, Sebastian Jessberger, Helena Mira, Antonella Consiglio, Emiley Pham, Eliezer Masliah, Fred H. Gage, and Roland Riek : In vivo demonstration that α-synuclein oligomers are toxic. In: Proc Natl Acad Sci U S A, 2011, 4194-4199
2011Beate Winner, Zacharias Kohl, Fred H. Gage: Neurodegenerative disease and adult neurogenesis. In: Eur J Neurosci, 2011, 1139-1151
2010Zacharias Kohl, Martin Regensburger, Robert Aigner, Mahesh Kandasamy, Beate Winner, Ludwig Aigner, and Jürgen Winkler: Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease. In: BMC Neurosci., 2010, 114
2010Christopher K. Glass, Kaoru Saijo, Beate Winner, Maria Carolina Marchetto, and Fred H. Gage : Mechanisms underlying inflammation in neurodegeneration. In: Cell, 2010, 918-934
2010Maria C.N. Marchetto, Beate Winner and Fred H. Gage: Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. In: Human Molecular Genetics, 2010, 71-76
2010Mahesh Kandasamy, Sebastien Couillard-Despres, Kerstin Raber, ;Michael Stephan; Bernadette Lehner, Beate Winner, Zacharias Kohl, Francisco J. Rivera, ; Huu Phuc Nguyen, Olaf Riess, Ulrich Bogdahn, Jürgen Winkler, Stephan von Hörsten, Ludwig Aigner: Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease. In: J Neuropathol Exp Neurol, 2010, 717-728
2009Kaoru Saijo, Beate Winner, Christian T. Carson, Jana G. Collier, Leah Boyer, Michael G. Rosenfeld, Fred H. Gage, and Christopher K. Glass: A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death. In: Cell, 2009, 47-59
2009Franz Marxreiter, Silke Nuber, Mahesh Kandasamy, Jochen Klucken, Robert Aigner, Ralf Burgmayer, Sebastien Couillard-Despres, Olaf Riess, Juergen Winkler and Beate Winner: Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein. In: European Journal of Neuroscience, 2009, 879-890
2008Gene W. Yeo, Nicole Coufal, Stefan Aigner, Beate Winner, Jonathan A. Scolnick, Maria C.N. Marchetto, Alysson R. Muotri, Christian Carson and Fred H. Gage: Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. In: Human Molecular Genetics, 2008, 67-75