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Prof. Dr. med. Karl Sebastian Lang

Profile

Academic positionFull Professor
Research fieldsGastroenterology,Pathology,Immunology
KeywordsVirus, Hepatitis, iNOS, Reaktive Oxygen Spezies (ROS), CD8+ T-Zellen

Current contact address

CountryGermany
CityEssen
InstitutionUniversität Duisburg-Essen
InstituteUniversitätsklinikum Essen

Host during sponsorship

Prof. Dr. Dieter HäussingerKlinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf
Prof. Dr. Jan BuerUniversitätsklinikum Essen, Universität Duisburg-Essen, Essen
Start of initial sponsorship01/12/2008

Programme(s)

2008Sofja Kovalevskaja Award Programme

Nominator's project description

The human body is under constant threat to be invaded by pathogens. Infectious diseases, such as HIV, viral hepatitis, malaria, and tuberculosis are amongst the most prevalent causes of death. The human body has developed a powerful immune system, which efficiently eliminates pathogens. However, the rigorous battle may cause collateral damage to our own cells, which even can exceed the damage caused by the pathogen itself. Moreover, our immune system may erroneously consider our own cells and structures as foreign, by mistake attack those and thus cause autoimmune disease, such as type I diabetes. The research of Dr. Lang aims to unravel the causes for errors of the immune system. In the past, he has discovered why viral disease could trigger type I diabetes. He now explores why some 20% of patients with hepatitis do not eliminate the virus but may end up with complete destruction of this essential organ. His most recent research discloses that the course of hepatitits critically depends not only on the immune system, but also on specific genes of liver cells. Dr. Lang hopes that understanding the causes of error will allow restraining the immune system and thus minimize collateral damage and self-destruction.

Publications (partial selection)

2015Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS: CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. In: Nat Commun, 2015,
2015Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA: Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection. In: J Virol, 2015, 4748-59
2015Shaabani N, Honke N, Dolff S, Görg B, Khairnar V, Merches K, Duhan 4, Metzger S, Recher M, Barthuber C, Hardt C, Proksch P, Häussinger D, Witzke O, Lang PA, Lang KS: IFN-γ licenses CD11b(+) cells to induce progression of systemic lupus erythematosus. In: J Autoimmun, 2015, 11-21
2015McIlwain DR, Grusdat M, Pozdeev VI, Xu HC, Shinde P, Reardon C, Hao Z, Beyer M, Bergthaler A, Häussinger D, Nolan GP, Lang KS, Lang PA: T-cell STAT3 is required for the maintenance of humoral immunity to LCMV. In: Eur J Immunol, 2015, 418-27
2015Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS: Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. In: Cell Death Differ, 2015, 164-73
2015Lang KS, Johnson TJ: Transcriptome modulations due to A/C2 plasmid acquisition. In: Plasmid, 2015, 83-9
2015Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS.: Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection. In: Cell Physiol Biochem, 2015, 2379-92
2014Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA: IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV. In: Cell Death Differ, 2014, 1050-60
2014Brenner D, Brüstle Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St Paul M, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, Mak TW: Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. In: Proc Natl Acad Sci U S A, 2014, 1060-5
2014Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA: Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity. In: Immunity, 2014, 949-60
2013Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Göthert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, Nolan GP, Hitoshi Y, Funkner P, Navarini AA, Verschoor A, Shaabani N, Honke N, Penn LZ, Ohashi PS, Häussinger D, Lee KH, Mak TW: Involvement of Toso in activation of monocytes, macrophages, and granulocytes. In: Proc Natl Acad Sci U S A, 2013, 2593-8
2013Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Maney SK, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, Ohashi PS, Hengartner H, Zinkernagel RM, Mak TW, Lang KS: Reactive oxygen species delay control of lymphocytic choriomeningitis virus. In: Cell Death Differ, 2013, 649-58
2013Honke N, Shaabani N, Zhang DE, Iliakis G, Xu HC, Häussinger D, Recher M, Löhning M, Lang PA, Lang KS: Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. In: PLoS Pathog, 2013,
2011Karl Sebastian Lang, PA Lang, D Graf, KM Boini, K Klingel, R Kandolf, F Lang: Cell volume, the serum and glucocorticoid intucible kinase 1 and the liver. In: Z Gastroenterol., 2011, 713 -719
2011Karl Sebastian Lang, C Ehlting, N Ronkina, O Böhmer, U Albrecht, KA Bode, A Kotlyarov, D Radzioch, M Gaestel, D Häussinger, JG Bode: Distinct functions of the mitogenactivated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK' mediates lipopolysaccharide-induced signal tranducers .... In: J Biol Chem, 2011, 24113-24124
2011Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Löhning M, Hengel H, Pfeffer K, Tanaka M, Häussinger D, Recher M, Lang PA, Lang KS: Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. In: Nat Immunol, 2011, 51-7
2011Karl Sebastian Lang, XH Nguyen, PA Lang, D Adam, G Fattakhova, N Föger, MA Kamal, P Prilla, S Mathieu, C Wagner, T Mak, AC Chan, KH Lee: Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. In: Blood, 2011, 598-608
2010Karl Sebastian Lang, PA Lang, M Recher, D Häussinger: Genes determining the course of virus persistence in the liver: lessons from murine infection with lymphocytic choriomeningitis virus. In: Cell Physiol Biochem, 2010, 263-272
2010Karl Sebastian Lang, AA Navarini, M Krzyzowska, E Horvath, H Hengartner, MG Niemialtowski, RM Zinkernagel: Long-lastig immunity by early infection of maternal-antibody-protected infants. In: Eur J Immunol, 2010, 113-116
2010Karl Sebastian Lang, PA Lang, D Merkler, P Funkner, N Shaabani, A Meryk, C Krings, C Barthuber, M Recher, W Brück, D Häussinger, PS Ohashi: Oxidized ATP inhibits T-Cell-mediated autoimmunity. In: Eur J Immunol., 2010, 2401-2408
131Lang P1, Shaabani N, Borkens S, Honke N, Scheu S, Booth S, Brenner D, Meryk A, Barthuber C, Recher M, Mak TW, Ohashi PS, Häussinger D, Griffiths GM, Thrasher AJ, Bouma G, Lang KS: Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency. In: J Allergy Clin Immunol, 131, 815-24
Göbel C, Breitenbuecher F, Kalkavan H, Hähnel PS, Kasper S, Hoffarth S, Merches K, Schild H, Lang KS, Schuler M: Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity. In: Cell Death Dis, ,