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Profile
| Academic position | Full Professor |
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| Research fields | General Genetics, Functional Genome Research |
| Keywords | Drosophila, Cancer, JNK, ATF3, oncogene cooperation |
Current contact address
| Country | Germany |
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| City | Köln |
| Institution | Universität zu Köln |
| Institute | Institut für Genetik |
Host during sponsorship
| Prof. Dr. Maria Leptin | Institut für Genetik, Universität zu Köln, Köln |
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| Prof. Dr. Dr. h.c. mult. Thomas Michael Krieg | Klinik und Poliklinik für Dermatologie und Venerologie, Translational Matrix Biology, Universität zu Köln, Köln |
| Start of initial sponsorship | 01/11/2008 |
Programme(s)
| 2008 | Sofja Kovalevskaja Award Programme |
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Nominator's project description
| Cancer has many causes. Almost any mechanism in a cell can be modified by molecular defects in such a way that it is diverted from its normal function to a pathological function that contributes to the development of cancer. But it is not sufficient for a cell to change its internal controls to become a cancer cell: It also has to communicate with its environment, modify its surroundings, and inactivate or ignore control signals from its neighbours. Such interactions between signalling processes cannot easily be studied in isolated cells in vitro and are therefore only beginning to be discovered and understood. Dr. Uhlirova has chosen to study them in vivo in the whole organism, using the fruit fly Drosophila. She has discovered new genes involved in these processes and will determine their functions in cell migration and the communication between tumors and their environment. |
Publications (partial selection)
| 2015 | Marek Jindra*, Mirka Uhlirova, Jean-Philippe Charles, Vlastimil Smykal, Ronald J. Hill*: Genetic Evidence for Function of the bHLH- PAS Protein Gce/Met As a Juvenile Hormone Receptor.. In: PLoS Genetics, 2015, e1005394 |
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| 2015 | Eva Külshammer,#, Juliane Mundorf,#, Merve Kilinc, Peter Frommolt, Prerana Wagle, Mirka Uhlirova*: Interplay among transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.. In: Disease Models & Mechanisms, 2015, 1279-1293 |
| 2014 | Ann-Katrin Claudius, Patrizia Romani, Tobias Lamkemeyer, Marek Jindra,*, Mirka Uhlirova,*: Unexpected Role of the Steroid-Deficiency Protein Ecdysoneless in Pre-mRNA Splicing.. In: PLoS Genetics, 2014, e1004287 |
| 2013 | Eva Külshammer, Mirka Uhlirova*: The actin cross-linker Filamin/Cheerio mediates tumor malignancy downstream of JNK signaling.. In: Journal of Cell Science, 2013, 927-938 |
| 2012 | Jan Rynes,#, Colin D. Donohoe,#, Peter Frommolt, Susanne Brodesser, Marek Jindra, Mirka Uhlirova*: Activating Transcription Factor 3 Regulates Immune and Metabolic Homeostasis.. In: Molecular and Cellular Biology, 2012, 3949-3962 |
| 2010 | Petra Sekyrova, Dirk Bohmann, Marek Jindra,*, Mirka Uhlirova,*: Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.. In: Development, 2010, 141-150 |
| 2010 | Qiong Wang, Mirka Uhlirova, Dirk Bohmann*: Spatial restriction of FGF signaling by a Matrix Metalloprotease controls branching morphogenesis. In: Developmental Cell, 2010, 157-164 |