Dr. Kuiying Xu

Profile

Academic positionPost Doc
Research fieldsPharmacy
Keywords17ß-hydroxysteroid dehydrogenases, inhibitors, steroids, osteoporosis, fluorine

Current contact address

CountryPeople's Republic of China
CityBeijing
InstitutionPeking University (PKU)
InstituteSchool of Pharmaceutical Science

Host during sponsorship

Prof. Dr. Rolf W. HartmannLehrstuhl für Pharmazeutische und Medizinische Chemie, Universität des Saarlandes, Saarbrücken
Start of initial sponsorship01/09/2008

Program(s)

2008Humboldt Research Fellowship Programme for Postdocs

Publications (partial selection)

2013Sandrine Marchais-Oberwinkler,Kuiying Xu, Marie Wetzel, Enrico Perspicace, Matthias Negri, Arne Meyer, Alex Odermatt, Gabriele Möller, Jerzy Adamski, Rolf W. Hartmann: Structural Optimization of 2,5-Thiophene Amides as Highly Potent and Selective 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors for the Treatment of Osteoporosis. In: J, Med. Chem., 2013, 167-181
2011Sandrine Marchais-Oberwinkler, Claudia Henn, Gabriele Möller, Tobias Klein, Matthias Negri, Alexander Oster, Alessandro Spadaro, Ruth Werth, Marie Wetzel, Kuiying Xu, Martin Frotscher, Rolf W. Hartmann, Jerzy Adamski: 17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development” . In: J. steroid biochem. Mol. biol., 2011, 66-82
2011Kuiying Xu, Marie Wetzel, Rolf W. Hartmann, Sandrine Marchais-Oberwinkler: Synthesis and Biological Evaluation of Spiro-d-lactones as Inhibitors of 17 β -Hydroxysteroid Dehydrogenase Type 2 (17 β -HSD2). In: Lett. Drug Design Disc, 2011, 406-421
2011Kuiying Xu, Yaseen A. Al-Soud, Marie Wetzel, Rolf W. Hartmann, Sandrine Marchais-Oberwinkle: Triazole ring-opening leads to the discovery of potent nonsteroidal 17β-hydroxysteroid dehydrogenase type 2 inhibitors. In: Eur. J. Med. Chem. , 2011, 5978-5990