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Profile
| Academic position | Associate Professor, Senior Lecturer, Reader |
|---|---|
| Research fields | Biochemistry,Haematology, Oncology |
| Keywords | childhood cancer, bioinformatics, proteomics, post-translational modification, systems biology |
| Honours and awards | 2020: Canada Research Chair in Translational Proteogenomics of Childhood Cancer 2020: CIHR Early Career Investigator in Cancer Award 2020: Distinguished Achievement Award - Overall Excellence Early Career - UBC 2016: Great Canadian Innovation Award - Canadian Cancer Society 2016: Michael Smith Foundation for Health Research Scholar 2015: Canada Research Chair in Translational Proteogenomics |
Current contact address
| Country | Canada |
|---|---|
| City | Vancouver |
| Institution | University of British Columbia |
| Institute | Department of Pathology |
| Homepage | www.langelab.med.ubc.ca |
Host during sponsorship
| Prof. Dr. Christopher Overall | Centre for Blood Research - Life Sciences Institute, University of British Columbia, Vancouver |
|---|---|
| Prof. Dr. Lawrence P. McIntosh | Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver |
| Start of initial sponsorship | 01/08/2009 |
Programme(s)
| 2009 | Feodor Lynen Research Fellowship Programme for Postdocs |
|---|
Publications (partial selection)
| 2021 | Rolf, Nina and Liu, Lorraine YT and Tsang, Angela and Lange, Philipp F and Lim, Chinten James and Maxwell, Christopher A and Vercauteren, Suzanne M and Reid, Gregor SD: A cross-standardized flow cytometry platform to assess phenotypic stability in precursor B-cell acute lymphoblastic leukemia (B-ALL) xenografts. In: CYTOMETRY PART A, 2021, |
|---|---|
| 2021 | Nierves, Lorenz and Lange, Philipp F: Detectability of Biotin Tags by LC--MS/MS. In: Journal of Proteome Research, 20, 2021, 3002--3008 |
| 2021 | Uzozie, Anuli C and Ergin, Enes K and Rolf, Nina and Tsui, Janice and Lorentzian, Amanda and Weng, Samuel SH and Nierves, Lorenz and Smith, Theodore G and Lim, C James and Maxwell, Christopher A and others: PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways. In: Journal of Experimental \& Clinical Cancer Research, 40, 2021, 1--24 |
| 2020 | Yu, Huaxu and Xing, Shipei and Nierves, Lorenz and Lange, Philipp F and Huan, Tao: Fold-change compression: an unexplored but correctable quantitative bias caused by nonlinear electrospray ionization responses in untargeted metabolomics. In: Analytical Chemistry, 92, 2020, 7011--7019 |
| 2020 | Richmond, Phillip A and Van Der Kloet, Frans and Vaz, Frederic M and Lin, David and Uzozie, Anuli and Graham, Emma and Kobor, Michael and Mostafavi, Sara and Moerland, Perry D and Lange, Philipp F and others: Multi-omic approach to identify phenotypic modifiers underlying cerebral demyelination in X-linked adrenoleukodystrophy. In: Frontiers in cell and developmental biology, 8, 2020, 520 |
| 2019 | Lorentzian, Amanda and Uzozie, Anuli and Lange, Philipp F: Origins and clinical relevance of proteoforms in pediatric malignancies. In: Expert review of proteomics, 16, 2019, 185--200 |
| 2019 | Weng, Samuel SH and Demir, Fatih and Ergin, Enes K and Dirnberger, Sabrina and Uzozie, Anuli and Tuscher, Domenic and Nierves, Lorenz and Tsui, Janice and Huesgen, Pitter F and Lange, Philipp F: Sensitive determination of proteolytic proteoforms in limited microscale proteome samples. In: Molecular \& cellular proteomics, 18, 2019, 2335--2347 |
| 2018 | Lorentzian, Amanda and Biegel, Jaclyn A and Ostrow, D Gigi and Rolf, Nina and Liu, Chi-Chao and Rassekh, S Rod and Deyell, Rebecca J and Triche, Timothy and Schultz, Kirk R and Rozmus, Jacob and others: Tumor variant identification that accounts for the unique molecular landscape of pediatric malignancies. In: JNCI cancer spectrum, 2, 2018, pky079 |
| 2017 | Connell, Marisa and Chen, Helen and Jiang, Jihong and Kuan, Chia-Wei and Fotovati, Abbas and Chu, Tony LH and He, Zhengcheng and Lengyell, Tess C and Li, Huaibiao and Kroll, Torsten and others: HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. In: Elife, 6, 2017, e28672 |
| 2016 | Eckhard, Ulrich and Huesgen, Pitter F and Schilling, Oliver and Bellac, Caroline L and Butler, Georgina S and Cox, Jennifer H and Dufour, Antoine and Goebeler, Verena and Kappelhoff, Reinhild and auf dem Keller, Ulrich and others: Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14. In: Data in brief, 7, 2016, 299--310 |
| 2016 | Eckhard, Ulrich and Huesgen, Pitter F and Schilling, Oliver and Bellac, Caroline L and Butler, Georgina S and Cox, Jennifer H and Dufour, Antoine and Goebeler, Verena and Kappelhoff, Reinhild and auf dem Keller, Ulrich and others: Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses. In: Matrix biology, 49, 2016, 37--60 |
| 2016 | Prudova, Anna and Gocheva, Vasilena and auf dem Keller, Ulrich and Eckhard, Ulrich and Olson, Oakley C and Akkari, Leila and Butler, Georgina S and Fortelny, Nikolaus and Lange, Philipp F and Mark, Jennifer C and others: TAILS N-terminomics and proteomics show protein degradation dominates over proteolytic processing by cathepsins in pancreatic tumors. In: Cell reports, 16, 2016, 1762--1773 |
| 2015 | Huesgen, Pitter F and Lange, Philipp F and Rogers, Lindsay D and Solis, Nestor and Eckhard, Ulrich and Kleifeld, Oded and Goulas, Theodoros and Gomis-Rüth, F Xavier and Overall, Christopher M: LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification. In: Nature methods, 12, 2015, 55--58 |
| 2015 | Fortelny, Nikolaus and Yang, Sharon and Pavlidis, Paul and Lange, Philipp F and Overall, Christopher M: Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre-and post-translational events. In: Nucleic acids research, 43, 2015, D290--D297 |
| 2014 | Lange, Philipp F and Huesgen, Pitter F and Nguyen, Karen and Overall, Christopher M: Annotating N termini for the human proteome project: N termini and N$\alpha$-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. In: Journal of proteome research, 13, 2014, 2028--2044 |
| 2014 | Huesgen, Pitter F and Lange, Philipp F and Overall, Christopher M: Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease. In: PROTEOMICS--Clinical Applications, 8, 2014, 338--350 |
| 2014 | Bellac, Caroline L and Dufour, Antoine and Krisinger, Michael J and Loonchanta, Anantasak and Starr, Amanda E and auf dem Keller, Ulrich and Lange, Philipp F and Goebeler, Verena and Kappelhoff, Reinhild and Butler, Georgina S and others: Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis. In: Cell reports, 9, 2014, 618--632 |
| 2014 | Fortelny, Nikolaus and Cox, Jennifer H and Kappelhoff, Reinhild and Starr, Amanda E and Lange, Philipp F and Pavlidis, Paul and Overall, Christopher M: Network analyses reveal pervasive functional regulation between proteases in the human protease web. In: PLoS biology, 12, 2014, e1001869 |
| 2013 | Lange, Philipp F and Overall, Christopher M: Protein TAILS: when termini tell tales of proteolysis and function. In: Current opinion in chemical biology, 17, 2013, 73--82 |
| 2013 | Huesgen, Pitter F and Alami, Meriem and Lange, Philipp F and Foster, Leonard J and Schröder, Wolfgang P and Overall, Christopher M and Green, Beverley R: Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids. In: PloS one, 8, 2013, e74483 |
| 2012 | Lange, Philipp F and Huesgen, Pitter F and Overall, Christopher M: TopFIND 2.0—linking protein termini with proteolytic processing and modifications altering protein function. In: Nucleic acids research, 40, 2012, D351--D361 |
| 2011 | Ying Li, Richard Ting, Curtis W. Harwig, Ulrich Keller auf dem, Caroline L. Bellac, Philipp F. Lange, James A. H. Inkster, Paul Schaffer, Michael J. Adam, Thomas J. Ruth, Christopher M. Overall, David M. Perrin: Towards kit-like 18F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases . In: MedChemComm, 2011, 942-949 |
| 2010 | Ulrich auf dem Keller Caroline L. Bellac, Ying Li, Yuanmei Lou, Philipp F. Lange, Richard Ting, Curtis Harwig, Reinhild Kappelhoff, Shoukat Dedhar, Michael J. Adam, Thomas J. Ruth, François Bénard, David M. Perrin, Christopher M. Overall: Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer. In: Cancer research, 2010, 7562-7569 |
| 2006 | Philipp F. Lange, Lena Wartosch, Thomas J. Jentsch, Jens C. Fuhrmann: ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function. In: Nature, 2006, 220-223 |