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Profile
| Academic position | Lecturer, Assistant Professor, Researcher |
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| Research fields | Organic Molecular Chemistry,Cell Biology |
| Keywords | Mitochondria Targeting NIR Organic Molecules, Synthetic Molecular/Supramolecular Machines, Membrane Fusion, Solid Phase Synthesis: Peptide, PNA, Molecular Recognition and Sensing |
| Honours and awards | 2018: DST-SERB Early Carrier Award, Government of India 2014: Florida State University, USA 2011: Alexander von Humboldt Fellowship for Postdoctoral Research 2006: Senior Research Fellowship, CSIR-NET, New Delhi, India 2004: Junior Research Fellowship, CSIR-NET, New Delhi, India 2004: National Scholarship, Calcutta University for B.Sc. |
Current contact address
Host during sponsorship
| Prof. Dr. Ulf Diederichsen | Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Göttingen |
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| Start of initial sponsorship | 01/11/2011 |
Programme(s)
| 2011 | Humboldt Research Fellowship Programme for Postdocs |
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Publications (partial selection)
| 2025 | Samiran Kar, Rabi Sankar Das, Tapas Bera, Aniruddha Mondal, Sucharita Ghara, Amalendu Roy, Priti Ghosh, Sahid Afridi, Samit Guha*: A Custom-Engineered Water-Soluble Peptide-Based Macrocyclic Polynuclear Gd3+-Chelated Paramagnetic Multimodal Contrast Agent for Mitochondria-Targeted Fluorescence Imaging Integrated with MRI. In: Analytical Chemistry, 97, 2025, 23183–23195 |
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| 2025 | T. Bera, A. Mondal, P. Ghosh, I. Ganguly, S. Dutta, S. Afridi, S. Ghara, A. Roy, Samit Guha* Design of Water-Soluble PEGylated Heptapeptide-Based Multifunctional Magnetic Nanovesicles for Cancer Targeted MRI Integrated With Fluorescence Imaging.. In: Small 21, 2025, 2504502 |
| 2025 | S. Mondal, J. An, T. Bera, M. Banerjee, S. Debnath, D. Mandal, A. Sikder, Samit Guha,* J. S. Kim,* N. D. P. Singh* Engineering a Green Fluorescent Protein-Core-Inspired NIR-Photocage: Exploring meso-GFP-PRPG toward Alzheimer’s Disease Therapeutics.. In: ACS Cent. Sci., 11, 2025, 1062–1070 |
| 2025 | S. Kar, R. S. Das, T. Bera, S. Das, A. Mukherjee, A. Mondal, A. Sengupta, Samit Guha*: Targeted NIR Fluorescent Mechanically Interlocked Molecules-Peptide Bioconjugate for Live Cancer Cells Submitochondrial Stimulated Emission Depletion Super-Resolution Microscopy.. In: Bioconjugate Chem. 36, 2025, 223–232 |
| 2024 | Sayani Hui, Pranab Saha, Samit Guha, Partha Mahata* A Two-Dimensional Cu-Based MOF for Selective Staining of Cellular Nucleus through Fluorescence Imaging and Selective Sorption of Dye Molecules in Aqueous Medium.. In: Inorg. Chem. 63, 2024, 13439–13449 |
| 2024 | A. Mukherjee, S. Kar, S. Das, T. Bera, A. Mondal, A. Sengupta, Samit Guha*: Design of an Acidic pH-Activated NIR Fluorescent Convertible Rhodamine−Hemicyanine Probe-Peptide Conjugate for Living Cancer Cell Active Targeted Selective Tracking of Lysosomes.. In: Chem. Eur. J. 30, 2024, e202402146 |
| 2024 | T. Bera, A. Mondal, S. Kar, A. Mukherjee, S. Banerjee, Samit Guha*: Mitochondria Targeted De Novo Designed Aggregation-Induced Emission Probe for Selective Detection of Neurotoxic Amyloid β Aggregates.. In: J. Mater. Chem. B, 12, 2024, 11368-11380 |
| 2024 | P. Maiti, S. Das, J. Panda, D. Karmakar, A. Pal, Samit Guha, A. Sengupta, S. Paul, P. K. Paul* Spectrofluorometric detection of mercury ions in aqueous medium and cellular milieu using MoS2 nanoflakes.. In: J. Phys. Chem. Solid 184, 2024, 111680 |
| 2023 | A. Mukherjee, P. C. Saha, S. Kar, P. Guha, R. S. Das, T. Bera, Samit Guha*: Acidic pH-Triggered Live-Cell Lysosome Specific Tracking, Ratiometric pH Sensing, and Multicolor Imaging by Visible to NIR Switchable Cy-7 Dyes.. In: ChemBioChem 24, 2023, e202200641 |
| 2023 | A. Sardar, T. Bera, S. K. Samal, N. Dewangan, M. Kamble, Samit Guha, P. K. Tarafdar* C-Terminal Lipidation of SARS-CoV-2 Fusion Peptide Reinstates Superior Membrane Fusion Catalytic Ability.. In: Chem. - Eur. J., 29, 2023, e202203034 |
| 2023 | R. S. Das, D. Maiti, S. Kar, T. Bera, A. Mukherjee, P. C. Saha, A. Mondal, Samit Guha*: Design of Water-Soluble Rotaxane-Capped Superparamagnetic, Ultrasmall Fe3O4 Nanoparticles for Targeted NIR Fluorescence Imaging in Combination with Magnetic Resonance Imaging.. In: J. Am. Chem. Soc. 145, 2023, 20451–20461 |
| 2023 | P. C. Saha, R. S. Das, S. Das, N. Sepay, T. Chatterjee, A. Mukherjee, T. Bera, S. Kar, M. Bhattacharyya, A. Sengupta, Samit Guha*: Live Cell Mitochondria Targeted NIR Fluorescent Covalent Labeling of Specific Proteins Using Dual Localization Effect.. In: Bioconjugate Chem. 34, 2023, 1407–1417 |
| 2022 | R. S. Das, A. Mukherjee, S. Kar, T. Bera, S. Das, A. Sengupta, Samit Guha* Construction of Red Fluorescent Dual Targeting Mechanically Interlocked Molecules for Live Cancer Cell Specific Lysosomal Staining and Multicolor Cellular Imaging.. In: Org. Lett. 24, 2022, 5907-5912 |
| 2022 | Tapas Bera, Pranab Chandra Saha, Tanima Chatterjee, Samiran Kar, Samit Guha* Construction of Self-Assembling Lipopeptide-Based Benign Nanovesicles to Prevent Amyloid Fibril Formation and Reduce Cytotoxicity of GxxxGxxxGxxxG Motif. . In: Bioconjugate Chem. 33, 2022, 1201–1209 |
| 2021 | A. Mukherjee, P. C. Saha, R. S. Das, T. Bera, Samit Guha* Acidic pH-Activatable Visible to Near-Infrared Switchable Ratiometric Fluorescent Probe for Live-Cell Lysosome Targeted Imaging.. In: ACS Sens. 6, 2021, 2141–2146 |
| 2021 | B. Paul, A. Mukherjee, D. Bhuyan, Samit Guha* Construction of Unsymmetrical Bis-Urea Macrocyclic Host for Neutral Molecule and Chloride Ion Binding.. In: J. Heterocycl. Chem. 58, 2021, 2033–2038 |
| 2021 | P. C. Saha, T. Bera, T. Chatterjee, J. Samanta, A. Sengupta, M. Bhattacharyya, Samit Guha*: Supramolecular Dipeptide-Based Near-Infrared Fluorescent Nanotubes for Cellular Mitochondria Targeted Imaging and Early Apoptosis.. In: Bioconjugate Chem, 32, 2021, 833–841 |
| 2020 | R. S. Das, P. C. Saha, N. Sepay, A. Mukherjee, S. Chatterjee, Samit Guha* Design and Synthesis of Near-Infrared Mechanically Interlocked Molecules for Specific Targeting of Mitochondria.. In: Org. Lett. 22, 2020, 5839–5843 |
| 2020 | R. S. Das, P. C. Saha, N. Sepay, A. Mukherjee, S. Chatterjee, Samit Guha* Design and Synthesis of Near-Infrared Mechanically Interlocked Molecules for Specific Targeting of Mitochondria.. In: Org. Lett. 22, 2020, 5839–5843 |
| 2020 | P. C. Saha, R. S. Das, T. Chatterjee, M. Bhattacharyya, Samit Guha*: Supramolecular β-Sheet Forming Peptide Conjugated with Near-Infrared Chromophore for Selective Targeting, Imaging, and Dysfunction of Mitochondria. In: Bioconjugate Chem. 31, 2020, 1301-1306 |
| 2019 | Pranab Chandra Saha, Tanima Chatterjee, Rudradip Pattanayak, Rabi Sankar Das, Ayan Mukherjee, Maitree Bhattacharyya, and Samit Guha*: Targeting and Imaging of Mitochondria Using Near-Infrared Cyanine Dye and Its Application to Multicolor Imaging.. In: ACS Omega , 2019, 14579-14588 |
| 2018 | Samit Guha*: Think Biology from Chemistry View Point. In: Med. & Analy. Chem. Int. J. , 2018, 000128 |
| 2016 | Samit Guha, Gillian Karen Shaw, Trevor M. Mitcham, Richard R. Bouchard, Bradley D. Smith*: Croconaine Rotaxane for Acid Activated Photothermal Heating and Ratiometric Photoacoustic Imaging of Acidic pH. In: Chem. Commun., 2016, 120-123 |
| 2016 | Jan-Dirk Wehland, Antonina S. Lygina, Pawan Kumar, Samit Guha, Barbara E. Hubrich, Reinhard Jahn, Ulf Diederichsen*: Role of the Transmembrane Domain in SNARE Protein Mediated Membrane Fusion: Peptide Nucleic Acid/Peptide Model Systems. In: Mol. Biosyst. , 2016, 2770-2776 |
| 2015 | Samit Guha, Scott K. Shaw, Graeme T. Spence, Felicia M. Roland, Bradley D Smith*: Clean Photothermal Heating and Controlled Release From Near Infrared Dye Doped Nanoparticles Without Oxygen Photosensitization.. In: Langmuir , 2015, 7826-7834 |
| 2015 | Pawan Kumar, Samit Guha, Ulf Diederichsen*: SNARE Protein Analog-Mediated Membrane Fusion. In: J. Pept. Sci. , 2015, 621-629 |
| 2015 | Mary Sajini Devadas, Tuphan Devkota, Samit Guha, Scott K. Shaw, Bradley D Smith, Gregory V. Hartland*: Spatial Modulation Spectroscopy for Imaging and Quantitative Analysis of Single Dye-Doped Organic Nanoparticles Inside Cells. In: Nanoscale , 2015, 9779-9785 |
| 2013 | Samit Guha, Julia Graf, Björn Göricke, Ulf Diederichsen*: Nucleobase Caged Peptide Nucleic Acids: PNA/PNA Duplex Destabilization and Light Triggered PNA/PNA Recognition.. In: J. Pept. Sci. , 2013, 415-422 |
| 2013 | Flynt S. Goodson, Dillip K. Panda, Shuvasree Ray, Atanu Mitra, Samit Guha, Sourav Saha*: Tunable Electronic Interactions between Anions and Perylenediimide. In: Org. Biomol. Chem., 2013, 4797-4803 |
| 2012 | Samit Guha, Flynt S. Goodson, Lucas J. Corson, Sourav Saha*: Boundaries of Anion/Naphthalenediimide Interactions: From Anion? Interactions to Anion-Induced Charge-Transfer and Electron-Transfer Phenomena.. In: J. Am. Chem. Soc. , 2012, 13679-13691 |
| 2012 | Samit Guha, Flynt S. Goodson, Ronald J. Clark, Sourav Saha*: Deciphering Anionpi-Acceptor Interactions and Detecting Fluoride Using a Naphthalenediimide-Based Pd(II) Coordination Polymer.. In: CrystEngComm, 2012, 1213-1215 |
| 2011 | Samit Guha, Flynt S. Goodson, Sovan Roy, Lucas J. Corson, Curtis A. Gravenmier, Sourav Saha*: Electronically Regulated Thermally and Light-Gated Electron Transfer from Anions to Naphthalenediimides.. In: J. Am. Chem. Soc. , 2011, 15256-15259 |
| 2011 | Samit Guha, Subhasish Roy, Arindam Banerjee*: Fluorescent Au@Ag CoreShell Nanoparticles with Controlled Shell Thickness and HgII Sensing. In: Langmuir , 2011, 13198-13205 |
| 2010 | Samit Guha, Michael G. B. Drew, Arindam Banerjee*: Construction of Supramolecular Helices and Breaking the Helicity by Forming Supramolecular ?-sheet structures Using Suitable Self-Assembling Pseudopeptide Building Blocks.. In: Cryst. Growth Des. , 2010, 4716-4721 |
| 2010 | Samit Guha, Sourav Saha*: Fluoride Ion Sensing by an Anion?? Interaction. In: J. Am. Chem. Soc. , 2010, 17674-17677 |
| 2009 | Samit Guha, Arindam Banerjee*: Macroporous Materials from Self-Assembling Synthetic Cyclic Peptide-Based Compounds and Deposition of Dipeptide-Capped Gold Nanoparticles on the Surfaces. . In: Macromol. Chem. Phys. , 2009, 1422-1432 |
| 2009 | Samit Guha, Arindam Banerjee*: Self-Assembled Robust Dipeptide Nanotubes and Fabrication of Dipeptide-Capped Gold Nanoparticles on the Surface of these Nanotubes. In: Adv. Funct. Mater. , 2009, 1949-1961 |
| 2009 | P. Ramasamy, Samit Guha, E. S. Shibu, T. S. Sreeprasad, Soumabha Bag, Arindam Banerjee*, Thalappil Pradeep* These two authors have contributed equally.: Size Tuning of Au Nanoparticles Formed by Electron Beam Irradiation of Au25 Quantum Clusters Anchored Within and Outside of Dipeptide Nanotubes.. In: J. Mater. Chem. , 2009, 8456-8462 |
| 2009 | Samit Guha, Michael G. B. Drew, Arindam Banerjee*: Solvent-Induced Dynamic Single-Crystal-to-Single-Crystal Transformation of a Synthetic Peptide-Based Cyclic Compound.. In: CrystEngComm , 2009, 756-762 |
| 2009 | Samit Guha, Tushar Chakraborty, Arindam Banerjee*: Water Soluble Synthetic Dieptide-Based Biodegradable Nanoporous Materials.. In: Green Chem. , 2009, 1139-1145 |
| 2008 | Samit Guha, Michael G. B. Drew, Arindam Banerjee*: Construction of Helical Nanofibers from Self-Assembling Pseudopeptide Building Blocks: Modulating the Handedness and Breaking the Helicity.. In: Small , 2008, 1993-2005 |
| 2008 | Samit Guha, Michael G. B. Drew, Arindam Banerjee*: Dipeptide Nanotubes, with N-Terminally Located ?-Amino Acid Residues, That are Stable Proteolytically, Thermally, and Over a Wide Range of pH.. In: Chem. Mater. , 2008, 2282-2290 |
| 2007 | Samit Guha, Michael G. B. Drew, Arindam Banerjee*: A New Molecular Scaffold for the Formation of Supramolecular Peptide Double Helices: The Crystallographic Insight.. In: Org. Lett., 2007, 1347-1350 |
| 2006 | Samit Guha, Michael G. B. Drew, Arindam Banerjee*: Formation of a One-Dimensional Helical Alignment of Water Molecules Within a Water-Mediated Supramolecular Helix Using Molecular Self-Assembly of a Water-Soluble Short Pseudopeptide.. In: Tetrahedron Lett. , 2006, 7951-7955 |