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Prof. Dr. Philipp Alexander Lang

Profile

Academic positionFull Professor
Research fieldsGastroenterology,Virology
KeywordsHepatitis, chronische Virusinfektionen, Antikörper, Autoimmunerkrankungen

Current contact address

CountryGermany
CityDüsseldorf
InstitutionHeinrich-Heine-Universität Düsseldorf
InstituteKlinik für Gastroenterologie, Hepatologie und Infektiologie

Host during sponsorship

Prof. Dr. Dieter HäussingerKlinik für Gastroenterologie, Hepatologie und Infektiologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf
Start of initial sponsorship01/11/2010

Programme(s)

2010Sofja Kovalevskaja Award Programme

Nominator's project description

Chronic hepatitis diseases triggered by viruses are a global health problem. It has been estimated that almost 10% of the world population suffer from such an infection. In chronic hepatitis diseases in particular, hardly any antibodies are formed to fight the viruses. In many cases, however, the severity of the disease cannot be attributed solely to the virus and a poor immune response. Often, misdirected defence reactions add to the condition in which antibodies attack the patient’s own tissue. Philipp Alexander Lang is examining why this is the case. For this purpose, he is applying two different infection models: infections developing owing to a cell-damaging virus and those for which a virus is to blame that does not cause any cell damage. By comparing the two infection models, Lang hopes to find out how the formation of those antibodies is promoted that really effectively attack the virus instead of the patient’s own body.

Publications (partial selection)

2012Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang Philipp Alexander, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD: B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. In: Blood, 2012, 2819-2828
2012Kaesler S, Sobiesiak M, Kneilling M, Volz T, Kempf WE, Lang Philipp Alexander, Lang KS, Wieder T, Heller-Stilb B, Warskulat U, Häussinger D, Lang F, Biedermann T : Effective T-cell recall responses require the taurine transporter Taut . In: European journal of immunology, 2012, 831-841
2012Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang Philipp Alexander, Ambagala T, Pellegrini M, Calzascia T, Aidarus N, Elford AR, Yue FY, Kremmer E, Kovacs CM, Benko E, Tremblay C, Routy JP, Bernard NF, Ostrowski MA, Ohashi PS, Watts TH : Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection . In: The Journal of experimental medicine , 2012, 77-91
2012Lang Philipp Alexander, Lang KS, Xu HC, Grusdat M, Parish IA, Recher M, Elford AR, Dhanji S, Shaabani N, Tran CW, Dissanayake D, Rahbar R, Ghazarian M, Brüstle A, Fine J, Chen P, Weaver CT, Klose C, Diefenbach A, Häussinger D, Carlyle JR, Kaech SM, Mak TW, Ohashi PS: Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. In: Proceedings of the National Academy of Sciences of the United States of America , 2012, 1210-5
2012Chen G, Dimitriou I, Milne L, Lang KS, Lang Philipp Alexander, Fine N, Ohashi PS, Kubes P, Rottapel R. : The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation . In: Journal of immunology, 2012, 2138-2150
2012Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang Philipp Alexander, Ohashi PS, Zhong Q, Wang X, Mak TW : The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis . In: The Journal of experimental medicine , 2012, 173-186
2012Brüstle A., Brenner D., Knobbe CB, Lang Philipp Alexander, Virtanen C, Hershenfield BM, Reardon C., Lacher SM, Ruland J, Ohashi PS, Mak TW : The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells . In: The Journal of clinical investigation, 2012, 4698-4709
2012Shaabani N, Honke N, Lang Philipp Alexander, Görg B, Proksch P, Gailus N, Gotoh T, Häussinger D, Lang KS : Tunicamycin inhibits diabetes. In: Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry and pharmacology, 2012, 595-602
2012McIlwain DR, Lang Philipp Alexander, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW: iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS . In: Science, 2012, 229-232
2011Philipp Alexander Lang, D. Graf, K. M. Boini, K. S. Lang, K. Klingel, R. Kandolf, F. Z. Lang: Cell volume, the serum and glucocorticoid inducible kinase 1 and the liver. In: Gastroenterol., 2011, 713-719
2011Philipp Alexander Lang, N. Honke, N. Shaabani, G. Cadeddu, U. R. Sorg, D. E. Zhang, M. Trilling, K. Klingel, M. Sauter, R. Kandolf, N. Gailus, n. van Rooijen, C. Burkart, S. E. Baldus, M. Gusdat, M. Löhning, H. Hengel, K. Pfeffer, M. Tanaka, D. Häussinger, M. Recher, K. S. Lang: Enforced viral replication activates adaptive immunity and is essential for the control of a cytophatic virus. In: Nat Immunol, 2011, 51-57