Prof. Dr. Andreas Möglich

Profile

Academic positionFull Professor
Research fieldsBiophysical Chemistry,Biochemistry,Plant Biochemistry and Biophysics
Keywordsphytochrome, transcription factor, cyclic nucleotide, light-oxygen-voltage, structure
Honours and awards

2010: Sofja-Kovalevskaya Award

Current contact address

CountryGermany
CityBayreuth
InstitutionUniversität Bayreuth
InstituteFakultät für Biologie, Chemie und Geowissenschaften

Host during sponsorship

Prof. Dr. Peter HegemannInstitut für Biologie, Biophysik, Humboldt-Universität zu Berlin, Berlin
Prof. Dr. Peter HegemannFakultät für Biologie, Chemie und Geowissenschaften, Universität Bayreuth, Bayreuth
Start of initial sponsorship01/07/2010

Programme(s)

2010Sofja Kovalevskaja Award Programme

Nominator's project description

To enable plants to grow towards the light, so-called photo-receptor proteins become active at molecular level. Light guides functions and behaviour in other organisms, too. Optogenetics, a new research field in which scientists like Andreas Möglich seek to influence or control genetically modified cells with the aid of light, takes advantage of this. In this manner, various naturally occurring photoreceptors have already been introduced in foreign organisms. Andreas Möglich aims to examine the function of natural photo-receptors more closely in order to make artificial photo-receptors. These artificial light switches can be employed and made use of in target organisms, for example to control the behaviour of laboratory animals such as worms or fruit-flies without involving any physical contact or to stimulate cells for therapeutic purposes.

Publications (partial selection)

2019Anna M. Weber, Jennifer Kaiser, Thea Ziegler, Sebastian Pilsl, Christian Renzl, Lisa Sixt, Georg Pietruschka, Sébastien Moniot, Ankana Kakoti, Marc Juraschitz, Stefanie Schrottke, Laura Lledo Bryant, Clemens Steegborn, Robert Bittl, Günter Mayer, Andreas Möglich: A blue light receptor that mediates RNA binding and translational regulation . In: Nat Chem Biol, 2019,
2019Birthe Stüven, Robert Stabel, Robert Ohlendorf, Julian Beck, Roman Schubert, Andreas Möglich: Characterization and engineering of photoactivated adenylyl cyclases. In: Biol Chem, 2019, 429-441
2019Tobias Baumann, Matthias Hauf, Florian Richter, Suki Albers, Andreas Möglich, Zoya Ignatova, Nediljko Budisa: Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine. In: Int J Mol Sci, 2019, E2343
2019Robert Stabel, Birthe Stüven, Jan N. Hansen, Heinz G. Körschen, Dagmar Wachten, Andreas Möglich: Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases. In: J Mol Biol, 2019,
2018Aba Losi, Kevin H. Gardner, Andreas Möglich: Blue-Light Receptors for Optogenetics. In: Chem Rev, 2018, 10659-10709
2018Julia Hennemann, Roman S. Iwasaki, Tamara N. Grund, Ralph P. Diensthuber, Florian Richter, Andreas Möglich: Optogenetic Control by Pulsed Illumination. In: Chembiochem, 2018, 1296-1304
2018Andreas Möglich: Signaltransduktion einer lichtregulierten Sensorhistidinkinase. In: Nachr Chem, 2018, 123-126
2017Christopher Engelhard, Ralph P. Diensthuber, Andreas Möglich, Robert Bittl: Blue-light reception through quaternary transitions. In: Sci Rep, 2017, 1385
2017Matthias Hauf, Florian Richter, Tobias Schneider, Thomas Faidt, Berta M. Martins, Tobias Baumann, Patrick Durkin, Holger Dobbek, Karin Jacobs, Andreas Möglich, Nediljko Budisa: Photoactivatable Mussel-Based Underwater Adhesive Proteins by an Expanded Genetic Code. In: Chembiochem, 2017, 1819-1823
2017Robert Stabel, Birthe Stüven, Robert Ohlendorf, Andreas Möglich: Primer-aided truncation for the creation of hybrid proteins. In: Meth Mol Biol, 2017, 287-304
2017Oskar Berntsson, Ralph P. Diensthuber, Matthijs R. Panman, Alexander Björling, Emil Gustavsson, Maria Hoernke, Ashley J. Hughes, Léocadie Henry, Stephan Niebling, Heikki Takala, Janne A. Ihalainen, Gemma Newby, Silke Kerruth, Joachim Heberle, Marianne Liebi, Andreas Menzel, Robert Henning, Irina Kosheleva, Andreas Möglich, Sebastian Westenhoff: Sequential conformational transitions and ?-helical supercoiling regulate a sensor histidine kinase. In: Nat Commun, 2017, 284
2017Florian Richter, Ines Fonfara, Renate Gelfert, Jennifer Nack, Emmanuelle Charpentier, Andreas Möglich: Switchable Cas9. In: Curr Opin Biotechnol, 2017, 119-126
2017Oskar Berntsson, Ralph P. Diensthuber, Matthijs R. Panman, Alexander Björling, Ashley J. Hughes, Léocadie Henry, Stephan Niebling, Gemma Newby, Marianne Liebi, Andreas Menzel, Robert Henning, Irina Kosheleva, Andreas Möglich, Sebastian Westenhoff: Time-Resolved X-Ray Solution Scattering Reveals the Structural Photoactivation of a Light-Oxygen-Voltage Photoreceptor. In: Structure, 2017, 933-938
2016Charlotte Helene Schumacher, Heinz Körschen, Christopher Nicol, Carlos Gasser, Reinhard Seifert, Martin Schwärzel, Andreas Möglich: A Fluorometric Activity Assay for Light-Regulated Cyclic-Nucleotide-Monophosphate Actuators. In: Methods in Molecular Biology, 2016, 93-105
2016Florian Richter, Ines Fonfara, Boris Bouazza, Charlotte Helene Schumacher, Emmanuelle Charpentier, Andreas Möglich: Engineering of temperature- and light-switchable Cas9 variants. In: Nucleic Acids Research, 2016, 10003-10014
2016Thea Ziegler, Charlotte Helene Schumacher, Andreas Möglich: Guidelines for Photoreceptor Engineering. In: Methods in Molecular Biology, 2016, 389-403
2016Robert Ohlendorf, Charlotte Helene Schumacher, Florian Richter, Andreas Möglich: Library-Aided Probing of Linker Determinants in Hybrid Photoreceptors. In: ACS Synthetic Biology, 2016, 1117-1126
2015Thea Ziegler, Andreas Möglich: Photoreceptor Engineering. In: Frontiers in Molecular Biosciences, 2015, 30
2015Estella Yee, Ralph Diensthuber, Anand Vaidya, Peter Borbat, Christopher Engelhard, Jack Freed, Robert Bittl, Andreas Möglich, Brian Crane: Signal transduction in light-oxygen-voltage receptors lacking the adduct-forming cysteine residue. In: Nature Communications, 2015, 10079
2015Florian Richter, Ulrike Scheib, Jennifer Mehlhorn, Roman Schubert, Jonas Wietek, Oliver Gernetzki, Peter Hegemann, Tilo Mathes, Andreas Möglich: Upgrading a Microplate Reader for Photobiology and All-Optical Experiments. In: Photochemical & Photobiological Sciences, 2015, 270-279
2014Ralph Diensthuber, Christopher Engelhard, Nora Lemke, Tobias Gleichmann, Robert Ohlendorf, Robert Bittl, Andreas Möglich: Biophysical, mutational and functional investigation of the chromophore-binding pocket of light-oxygen-voltage photoreceptors. In: ACS Synthetic Biology, 2014, 811-819
2014Carlos Gasser, Simone Taiber, Chen-Min Yeh, Charlotte Helene Wittig, Peter Hegemann, Soojin Ryu, Frank Wunder, Andreas Möglich: Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase. In: Proceedings of the National Academy of Sciences USA, 2014, 8803-8808
2013Christopher Engelhard, Sarah Raffelberg, Yifen Tang, Ralph Diensthuber, Andreas Möglich, Aba Losi, Wolfgang Gärtner, Robert Bittl: A structural model for the full-length blue light-sensing protein YtvA from Bacillus subtilis, based on EPR spectroscopy. In: Photochemical & Photobiological Sciences, 2013, 1855-1863
2013Andreas Möglich, Peter Hegemann: Biotechnology: Programming genomes with light. In: Nature, 2013, 406-408
2013Tobias Gleichmann, Ralph Diensthuber, Andreas Möglich: Charting the Signal Trajectory in a Light-Oxygen-Voltage Photoreceptor by Random Mutagenesis and Covariance Analysis. In: Journal of Biological Chemistry, 2013, 29345-29355
2013Nathan Rockwell, Robert Ohlendorf, Andreas Möglich: Cyanobacteriochromes in full color and three dimensions. In: Proceedings of the National Academy of Sciences USA, 2013, 806-807
2013Ralph Diensthuber, Martin Bommer, Tobias Gleichmann, Andreas Möglich: Full-length structure of a sensor histidine kinase pinpoints coaxial coiled coils as signal transducers and modulators. In: Structure, 2013, 1127-1136
2013Ralph Diensthuber, Robert Ohlendorf, Tobias Gleichmann, Roman Schubert, Andreas Möglich: Lichtregulierte Genexpression. In: Biospektrum, 2013, 149-151
2013Keith Moffat, Klaus Hahn, Feng Zhang, Andreas Möglich: The Biophysics and Engineering of Signaling Photoreceptors. In: Peter Hegemann, Stefan Sigrist, Optogenetics. De Gruyter, 2013. 7-22
2012Robert Ohlendorf, Roee Vidavski, Avigdor Eldar, Keith Moffat, Andreas Möglich: From Dusk Till Dawn: One-Plasmid Systems for Light-regulated Gene Expression. In: Journal of Molecular Biology, 2012, 534-542
2011Peter Hegemann, Andreas Möglich: Channelrhodopsin engineering and exploration of new optogenetic tools. In: Nature Methods, 2011, 39-42