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Profile
| Academic position | Associate Professor, Senior Lecturer, Reader |
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| Research fields | Organic Molecular Chemistry,Biochemistry,Cell Biology |
| Keywords | medicinal chemistry, target identification, Chemical biology, lipid transport, chemical proteomics |
| Honours and awards | 2024: RSC Medicinal Chemistry Emerging Investigator Lectureship 2022: Bürgenstock JSP Fellowship 2022: European Research Council Starting Grant 2021: Novo Nordisk Foundation Hallas Møller Emerging Investigator Grant |
Current contact address
| Country | Denmark |
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| City | Lyngby |
| Institution | Technical University of Denmark (DTU) |
| Institute | Department of Chemistry |
Host during sponsorship
| Prof. Dr. Dr. h.c. Herbert Waldmann | Abteilung Chemische Biologie, Max-Planck-Institut für molekulare Physiologie, Dortmund |
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| Start of initial sponsorship | 01/07/2014 |
Programme(s)
| 2014 | Humboldt Research Fellowship Programme for Postdocs |
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Publications (partial selection)
| 2024 | He, Nianzhe and Depta, Laura and Sievers, Sonja and Laraia, Luca: Fluorescent probes and degraders of the sterol transport protein Aster-A. In: Bioorganic \& Medicinal Chemistry, 2024, 117673 |
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| 2023 | Yao, Ruwei and Jensen, Anders A and Bryce-Rogers, Hogan P and Schultz-Knudsen, Katrine and Zhou, Libin and Hovendal, Nicklas P and Pedersen, Henrik and Kubus, Mariusz and Ulven, Trond and Laraia, Luca: Identification of 5-HT2 serotonin receptor modulators through the synthesis of a diverse, tropane-and quinuclidine-alkaloid-inspired compound library. In: Journal of Medicinal Chemistry, 66, 2023, 11536--11554 |
| 2023 | Whitmarsh-Everiss, Thomas and Wang, Zhou and Hauberg Hansen, Cecilie and Depta, Laura and Sassetti, Elisa and Rafn Dan, Oliver and Pahl, Axel and Sievers, Sonja and Laraia, Luca: Identification of Biologically Diverse Tetrahydronaphthalen-2-ols through the Synthesis and Phenotypic Profiling of Chemically Diverse, Estradiol-Inspired Compounds. In: ChemBioChem, 24, 2023, e202200555 |
| 2023 | Hoock, Joseph GF and Rossetti, Cecilia and Bilgin, Mesut and Depta, Laura and Enemark-Rasmussen, Kasper and Christianson, John C and Laraia, Luca: Identification of non-conventional small molecule degraders and stabilizers of squalene synthase. In: Chemical Science, 14, 2023, 12973--12983 |
| 2023 | Dekker, Nienke Julia and Laraia, Luca: Making bubbles: Targeting VPS41 induces vacuolization and methuosis. In: Cell Chemical Biology, 30, 2023, 127--129 |
| 2023 | Cigler, Marko and Imrichova, Hana and Frommelt, Fabian and Depta, Laura and Rukavina, Andrea and Kagiou, Chrysanthi and Hannich, J Thomas and Mayor-Ruiz, Cristina and Superti-Furga, Giulio and Sievers, Sonja and others: Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP. In: bioRxiv, 2023, 2023--03 |
| 2023 | Cigler, Marko and Imrichova, Hana and Frommelt, Fabian and Rukavina, Andrea and Kagiou, Chrysanthi and Sievers, Sonja and Laraia, Luca and Superti-Furga, Giulio and Waldmann, Herbert and Winter, Georg E: Probing leukemic vulnerabilities via small molecules inspired by natural products withanolides. Book of Abstracts. 2023. 13 |
| 2023 | Krell-J{\o}rgensen, Mikkel and Zulfikri, Habiburrahman and Bonnevie, Magnus Grage and Bro, Frederik Simonsen and Dohn, Asmus Ougaard and Laraia, Luca: Redshifted and thermally bistable one-way quantitative hemithioindigo-derived photoswitches enabled by isomer-specific excited state intramolecular proton transfer. In: Chemical Communications, 59, 2023, 563--566 |
| 2023 | He, Nianzhe and Depta, Laura and Rossetti, Cecilia and Cigler, Marko and Michon, Marine and Dan, Oliver Rafn and Hoock, Joseph and Barbier, Julien and Gillet, Daniel and Forrester, Alison and others: Selective inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation. In: bioRxiv, 2023, 2023--04 |
| 2022 | Bargum, Martin and Krell-J{\o}rgensen, Mikkel and Nielsen, Martin and Qvortrup, Katrine and Laraia, Luca: A photochemical microfluidic reactor for photosensitized [2+ 2] cycloadditions. In: Synlett, 33, 2022, 1083--1086 |
| 2022 | Depta, Laura and Whitmarsh-Everiss, Thomas and Laraia, Luca: Structure, function and small molecule modulation of intracellular sterol transport proteins. In: Bioorganic \& Medicinal Chemistry, 68, 2022, 116856 |
| 2022 | Rossetti, Cecilia and Laraia, Luca: Thermal proteome profiling reveals distinct target selectivity for differentially oxidized oxysterols. In: ACS Chemical Biology, 17, 2022, 1677--1684 |
| 2021 | Whitmarsh-Everiss, Thomas and Olsen, Asger Hegelund and Laraia, Luca: Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol-Inspired Compound Collection. In: Angewandte Chemie, 133, 2021, 26959--26965 |
| 2021 | Karageorgis, George and Foley, Daniel J and Laraia, Luca and Brakmann, Susanne and Waldmann, Herbert: Pseudo natural products—chemical evolution of natural product structure. In: Angewandte Chemie International Edition, 60, 2021, 15705--15723 |
| 2021 | Whitmarsh-Everiss, Thomas and Laraia, Luca: Small molecule probes for targeting autophagy. In: Nature chemical biology, 17, 2021, 653--664 |
| 2021 | Sassetti, Elisa and Clausen, Mads H and Laraia, Luca: Small-molecule inhibitors of reactive oxygen species production. In: Journal of Medicinal Chemistry, 64, 2021, 5252--5275 |
| 2021 | Nöcker, Christina and Kaiser, Nadine and Foley, Daniel and Sievers, Sonja and Janning, Petra and Waldmann, Herbert and Laraia, Luca: Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones. In: Tetrahedron, 87, 2021, 132118 |
| 2021 | Corrales, Marjorie A Carnero and Zinken, Sarah and Konstantinidis, Georgios and Rafehi, Muhammad and Abdelrahman, Aliaa and Wu, Yao-Wen and Janning, Petra and Müller, Christa E and Laraia, Luca and Waldmann, Herbert: Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin. In: Cell chemical biology, 28, 2021, 1750--1757 |
| 2020 | Laraia, Luca and Garivet, Guillaume and Foley, Daniel J and Kaiser, Nadine and Müller, Sebastian and Zinken, Sarah and Pinkert, Thomas and Wilke, Julian and Corkery, Dale and Pahl, Axel and others: Image-based morphological profiling identifies a lysosomotropic, Iron-sequestering autophagy inhibitor. In: Angewandte Chemie International Edition, 59, 2020, 5721--5729 |
| 2020 | Foley, Daniel J and Zinken, Sarah and Corkery, Dale and Laraia, Luca and Pahl, Axel and Wu, Yao-Wen and Waldmann, Herbert: Phenotyping reveals targets of a pseudo-Natural-product autophagy inhibitor. In: Angewandte Chemie International Edition, 59, 2020, 12470--12476 |
| 2020 | Karageorgis, George and Foley, Daniel J and Laraia, Luca and Waldmann, Herbert: Principle and design of pseudo-natural products. In: Nature Chemistry, 12, 2020, 227--235 |
| 2019 | Huggins, David J and Hardwick, Bryn S and Sharma, Pooja and Emery, Amy and Laraia, Luca and Zhang, Fengzhi and Narvaez, Ana J and Roberts-Thomson, Meredith and Crooks, Alex T and Boyle, Robert G and others: Development of a Novel Cell-Permeable Protein--Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1. In: ACS omega, 5, 2019, 822--831 |
| 2019 | Brennecke, Philip and Rasina, Dace and Aubi, Oscar and Herzog, Katja and Landskron, Johannes and Cautain, Bastien and Vicente, Francisca and Quintana, Jordi and Mestres, Jordi and Stechmann, Bahne and others: EU-OPENSCREEN: a novel collaborative approach to facilitate chemical biology. In: SLAS DISCOVERY: Advancing Life Sciences R\&D, 24, 2019, 398--413 |
| 2019 | Recino, Asha and Barkan, Kerry and Schmidt-Christensen, Anja and Nilsson, Julia and Holmes, Nick and Howie, Duncan and Holmberg, Dan and Larsson, Pär and Flodström-Tullberg, Malin and Laraia, Luca and others: GLP-1R is downregulated in beta cells of NOD mice and T1D patients. In: bioRxiv, 2019, 845776 |
| 2019 | Kaiser, Nadine and Corkery, Dale and Wu, Yaowen and Laraia, Luca and Waldmann, Herbert: Modulation of autophagy by the novel mitochondrial complex I inhibitor Authipyrin. In: Bioorganic \& Medicinal Chemistry, 27, 2019, 2444--2448 |
| 2019 | Ceballos, Javier and Schwalfenberg, Melanie and Karageorgis, George and Reckzeh, Elena S and Sievers, Sonja and Ostermann, Claude and Pahl, Axel and Sellstedt, Magnus and Nowacki, Jessica and Carnero Corrales, Marjorie A and others: Synthesis of Indomorphan pseudo-natural product inhibitors of glucose transporters GLUT-1 and-3. In: Angewandte Chemie, 131, 2019, 17172--17181 |
| 2019 | Laraia, Luca and Friese, Alexandra and Corkery, Dale P and Konstantinidis, Georgios and Erwin, Nelli and Hofer, Walter and Karatas, Hacer and Klewer, Laura and Brockmeyer, Andreas and Metz, Malte and others: The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. In: Nature chemical biology, 15, 2019, 710--720 |
| 2018 | Laraia, Luca and Robke, Lucas and Waldmann, Herbert: Bioactive compound collections: from design to target identification. In: Chem, 4, 2018, 705--730 |
| 2018 | Robke, Lucas and Rodrigues, Tiago and Schröder, Peter and Foley, Daniel J and Bernardes, Gon{\c{c}}alo JL and Laraia, Luca and Waldmann, Herbert: Discovery of 2, 4-dimethoxypyridines as novel autophagy inhibitors. In: Tetrahedron, 74, 2018, 4531--4537 |
| 2017 | Laraia, Luca and Ohsawa, Kosuke and Konstantinidis, Georgios and Robke, Lucas and Wu, Yao-Wen and Kumar, Kamal and Waldmann, Herbert: Discovery of novel cinchona-alkaloid-inspired oxazatwistane autophagy inhibitors. In: Angewandte Chemie International Edition, 56, 2017, 2145--2150 |
| 2017 | Xu, Hao and Laraia, Luca and Schneider, Laura and Louven, Kathrin and Strohmann, Carsten and Antonchick, Andrey P and Waldmann, Herbert: Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Novel Autophagy Inhibitor Class. In: Angewandte Chemie International Edition, 2017, |
| 2017 | Laraia, Luca and Waldmann, Herbert: Natural product inspired compound collections: evolutionary principle, chemical synthesis, phenotypic screening, and target identification. In: Drug Discovery Today: Technologies, 23, 2017, 75--82 |
| 2017 | Klein, Andreas S and Domröse, Andreas and Bongen, Patrick and Brass, Hannah UC and Classen, Thomas and Loeschcke, Anita and Drepper, Thomas and Laraia, Luca and Sievers, Sonja and Jaeger, Karl-Erich and others: New prodigiosin derivatives obtained by mutasynthesis in Pseudomonas putida. In: ACS synthetic biology, 6, 2017, 1757--1765 |
| 2017 | Robke, Lucas and Laraia, Luca and Carnero Corrales, Marjorie A and Konstantinidis, Georgios and Muroi, Makoto and Richters, Andr{\'e} and Winzker, Michael and Engbring, Tobias and Tomassi, Stefano and Watanabe, Nobumoto and others: Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. In: Angewandte Chemie International Edition, 2017, |
| 2017 | Laraia, Luca and Waldmann, Herbert: Synthesis and Target Identification of Natural Product--Inspired Compound Collections. Chemical Biology of Natural Products. Taylor \& Francis, 2017. 529--554 |
| 2015 | Laraia, Luca and McKenzie, Grahame and Spring, David R and Venkitaraman, Ashok R and Huggins, David J: Overcoming chemical, biological, and computational challenges in the development of inhibitors targeting protein-protein interactions. In: Chemistry \& biology, 22, 2015, 689--703 |
| 2015 | Alza, Esther and Laraia, Luca and Ibbeson, Brett M and Collins, S{\'u}il and Galloway, Warren RJD and Stokes, Jamie E and Venkitaraman, Ashok R and Spring, David R: Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck--Suzuki reaction. In: Chemical Science, 6, 2015, 390--396 |
| 2014 | Galloway, Warren RJD and Wilcke, David and Nie, Feilin and Hadje-Georgiou, Kathy and Laraia, Luca and Spring, David R: Diversity-Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems. In: Concepts and case studies in chemical biology, 2014, 379--390 |
| 2014 | Ibbeson*, Brett M and Laraia*, Luca and Alza, Esther and O'Connor, Cornelius J and Tan, Yaw Sing and Davies, Huw ML and McKenzie, Grahame and Venkitaraman, Ashok R and Spring, David R: Diversity-oriented synthesis as a tool for identifying new modulators of mitosis. In: Nature Communications, 5, 2014, |
| 2014 | Lau, Yu Heng and De Andrade, Peterson and Quah, Soo-Tng and Rossmann, Maxim and Laraia, Luca and Sköld, Niklas and Sum, Tze Jing and Rowling, Pamela JE and Joseph, Thomas L and Verma, Chandra and others: Functionalised staple linkages for modulating the cellular activity of stapled peptides. In: Chemical Science, 5, 2014, 1804--1809 |
| 2014 | Laraia, Luca and Stokes, Jamie and Emery, Amy and McKenzie, Grahame J and Venkitaraman, Ashok R and Spring, David R: High content screening of diverse compound libraries identifies potent modulators of tubulin dynamics. In: ACS Medicinal Chemistry Letters, 5, 2014, 598--603 |
| 2013 | Laraia, Luca and Spring, David R: Chemical library screening approaches to aid the design of protein--protein inhibitors. . Future Science Ltd, 2013. |
| 2013 | Laraia, Luca and Venkitaraman, Ashok R and Spring, David R: Diversity-oriented synthesis and phenotypic screening identifies novel small molecule regulators of mitosis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2013. |
| 2012 | Zheng, Shaojun and Aves, Sarah J and Laraia, Luca and Galloway, Warren RJD and Pike, Kurt G and Wu, Wenjun and Spring, David R: A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives. In: Chemistry--A European Journal, 18, 2012, 3193--3198 |
| 2012 | O'Connell, Kieron MG and Beckmann, Henning SG and Laraia, Luca and Horsley, Helen T and Bender, Andreas and Venkitaraman, Ashok R and Spring, David R: A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds. In: Organic \& Biomolecular Chemistry, 10, 2012, 7545--7551 |
| 2012 | Frye, Elizabeth C and O'Connor, Cornelius J and Twigg, David G and Elbert, Bryony and Laraia, Luca and Hulcoop, David G and Venkitaraman, Ashok R and Spring, David R: Palladium-Catalysed Cross-Coupling of Vinyldisiloxanes with Benzylic and Allylic Halides and Sulfonates. In: Chemistry--A European Journal, 18, 2012, 8774--8779 |
| 2012 | Zheng, Shaojun and Laraia, Luca and O'Connor, Cornelius J and Sorrell, David and Tan, Yaw Sing and Xu, Zhaochao and Venkitaraman, Ashok R and Wu, Wenjun and Spring, David R: Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity. In: Organic \& Biomolecular Chemistry, 10, 2012, 2590--2593 |
| 2011 | O'Connor, Cornelius J and Laraia, Luca and Spring, David R: Chemical genetics. In: Chemical Society Reviews, 40, 2011, 4332--4345 |
| 2011 | Sore, Hannah F and Boehner, Christine M and Laraia, Luca and Logoteta, Patrizia and Prestinari, Cora and Scott, Matthew and Williams, Katharine and Galloway, Warren RJD and Spring, David R: Vinyldisiloxanes: their synthesis, cross coupling and applications. In: Organic \& Biomolecular Chemistry, 9, 2011, 504--515 |
| 2010 | Spivey, Alan C and Laraia, Luca and Bayly, Andrew R and Rzepa, Henry S and White, Andrew JP: Stereoselective Synthesis of cis-and trans-2, 3-Disubstituted Tetrahydrofurans via Oxonium- Prins Cyclization: Access to the Cordigol Ring System. In: Organic letters, 12, 2010, 900--903 |