Dr. Qiang Guo

Profile

Academic positionLecturer, Assistant Professor, Researcher
Research fieldsBiophysics,Molecular Biology and Physiology of Neurons and Glial Cells
Keywordscryo-electrin tomography, tau, prion-like, neurodegenerative diseases

Current contact address

CountryPeople's Republic of China
CityPeking
InstitutionPeking University (PKU)
InstituteSchool of Life Sciences

Host during sponsorship

Prof. Dr. Wolfgang BaumeisterAbteilung Molekulare Strukturbiologie, Max-Planck-Institut für Biochemie, Martinsried
Start of initial sponsorship01/08/2016

Programme(s)

2015Humboldt Research Fellowship Programme for Postdocs

Publications (partial selection)

2020Yasuda, Sayaka and Tsuchiya, Hikaru and Kaiho, Ai and Guo, Qiang and Ikeuchi, Ken and Endo, Akinori and Arai, Naoko and Ohtake, Fumiaki and Murata, Shigeo and Inada, Toshifumi and Baumeister, Wolfgang and Fern{\'{a}}ndez-Busnadiego, Rub{\'{e}}n and Tanaka, Keiji and Saeki, Yasushi: {Stress- and ubiquitylation-dependent phase separation of the proteasome}. In: Nature, 578, 2020, 296--300
2018Zhao, Yixiu and Zeng, Xiangrui and Guo, Qiang and Xu, Min: {An integration of fast alignment and maximum-likelihood methods for electron subtomogram averaging and classification}. In: Bioinformatics, 34, 2018, i227--i236
2018Guo, Qiang and Lehmer, Carina and Mart{\'{i}}nez-S{\'{a}}nchez, Antonio and Rudack, Till and Beck, Florian and Hartmann, Hannelore and P{\'{e}}rez-Berlanga, Manuela and Frottin, Fr{\'{e}}d{\'{e}}ric and Hipp, Mark S. and Hartl, F. Ulrich and Edbauer, Dieter and Baumeister, Wolfgang and Fern{\'{a}}ndez-Busnadiego, Rub{\'{e}}n: {In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment}. In: Cell, 2018, 696--705
2018Rigort, Alexander and Guo, Qiang and B{\"{a}}uerlein, Felix J.B. and Fern{\'{a}}ndez-Busnadiego, Rub{\'{e}}n: {The combination of cryo-FIB and in situ cryo-electron tomography enables ultrastructural analysis of disease-related protein aggregates}. In: Microscopy and Analysis, 2018, S4
2018Guo, Qiang and {Bin Huang} and Cheng, Jingdong and Seefelder, Manuel and Engler, Tatjana and Pfeifer, G{\"{u}}nter and Oeckl, Patrick and Otto, Markus and Moser, Franziska and Maurer, Melanie and Pautsch, Alexander and Baumeister, Wolfgang and Fern{\'{a}}ndez-Busnadiego, Rub{\'{e}}n and Kochanek, Stefan: {The cryo-electron microscopy structure of huntingtin}. In: Nature, 555, 2018, 117--120
2017Li, Zhifei and Guo, Qiang and Zheng, Lvqin and Ji, Yongsheng and Xie, Yi Ting and Lai, De Hua and Lun, Zhao Rong and Suo, Xun and Gao, Ning: {Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii}. In: Cell Research, 27, 2017, 1275--1288
2015Mi, Na and Chen, Yang and Wang, Shuai and Chen, Mengran and Zhao, Mingkun and Yang, Guang and Ma, Meisheng and Su, Qian and Luo, Sai and Shi, Jingwen and Xu, Jia and Guo, Qiang and Gao, Ning and Sun, Yujie and Chen, Zhucheng and Yu, Li: {CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane}. In: Nature Cell Biology, 17, 2015, 1112--1123
2014Feng, Boya and Mandava, Chandra Sekhar and Guo, Qiang and Wang, Jie and Cao, Wei and Li, Ningning and Zhang, Yixiao and Zhang, Yanqing and Wang, Zhixin and Wu, Jiawei and Sanyal, Suparna and Lei, Jianlin and Gao, Ning: {Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase}. In: PLoS Biology, 12, 2014, e1001866
2014Yang, Zhixiu and Guo, Qiang and Goto, Simon and Chen, Yuling and Li, Ningning and Yan, Kaige and Zhang, Yixiao and Muto, Akira and Deng, Haiteng and Himeno, Hyouta and Lei, Jianlin and Gao, Ning: {Structural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence.}. In: Protein {\&} cell, 5, 2014, 394--407
2013Li, Ningning and Chen, Yuling and Guo, Qiang and Zhang, Yixiao and Yuan, Yi and Ma, Chengying and Deng, Haiteng and Lei, Jianlin and Gao, Ning: {Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit}. In: Nucleic Acids Research, 41, 2013, 7073--7083
2013Guo, Qiang and Goto, Simon and Chen, Yuling and Feng, Boya and Xu, Yanji and Muto, Akira and Himeno, Hyouta and Deng, Haiteng and Lei, Jianlin and Gao, Ning: {Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process}. In: Nucleic Acids Research, 41, 2013, 2609--2620
2012Huang, Weijiao and Choi, Wooyoung and Hu, Wanqiu and Mi, Na and Guo, Qiang and Ma, Meisheng and Liu, Mei and Tian, Yuan and Lu, Peilong and Wang, Feng Liang and Deng, Haiteng and Liu, Lei and Gao, Ning and Yu, Li and Shi, Yigong: {Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein}. In: Cell Research, 22, 2012, 473--489
2011Guo, Qiang and Yuan, Yi and Xu, Yanji and Feng, Boya and Liu, Liang and Chen, Kai and Sun, Ming and Yang, Zhixiu and Lei, Jianlin and Gao, Ning: {Structural basis for the function of a small GTPase RsgA on the 30S ribosomal subunit maturation revealed by cryoelectron microscopy.}. In: Proceedings of the National Academy of Sciences of the United States of America, 108, 2011, 13100--5