Prof. Dr. Sherif Saeed Ebada Elsayed

Profile

Academic positionFull Professor
Research fieldsNatural Product Chemistry,Metabolism, Biochemistry, and Genetics of Microorganisms
KeywordsAntibiotic resistance, Fungi, Secondary metabolites, Biofilm inhibition, Quorum quenching

Current contact address

CountryEgypt
CityCairo
InstitutionAin Shams University
InstituteFaculty of Pharmacy

Host during sponsorship

Prof. Dr. Marc StadlerAbteilung Mikrobielle Wirkstoffe, Helmholtz-Zentrum für Infektionsforschung GmbH, Braunschweig
Start of initial sponsorship01/09/2022

Programme(s)

2021Georg Forster Research Fellowship Programme for Experienced Researchers

Publications (partial selection)

2024Elnaggar, M.S., Mostafa, N.M., Elissawy, A.M., Phutthacharoen, K., Eckhardt, P., Sandargo, B., van Geelen, L., Ebada, S.S.,* Opatz, T., Singab, A.N.B.,* Kalscheuer, R.*: Acremochlorin S and Other Prenylated Chlorophenol Antimicrobial Metabolites from the Fungus Acremonium sp. Strain MNA-F-1. In: Fitoterapia, 179, 2024, 106254
2024Phutthacharoen, K., Llanos-López, N.A., Toshe, R., Noisripoom,W., Khonsanit, A., Luangsa-ard, J.J., Hyde, K.D., Ebada, S.S.,* Stadler, M.* Bioactive Bioxanthracene and Cyclodepsipeptides from the Entomopathogenic Fungus Blackwellomyces roseostromatus BCC56290. In: Antibiotics, 13, 2024, 585
2024Toshe, R.; Charria-Giron, E.; Khonsanit, A.; Luangsa-ard, J.J.; Khalid, S.J.; Schrey, H.; Ebada, S.S.; Stadler, M. Bioprospection of tenellins produced by the entomopathogenic fungus Beauveria neobassiana. In: Journal of Fungi, 10, 2024, doi: 10.3390/jof10010069
2024Cedeño-Sanchez, M., Lambert, C., Fournier, J, Mejia, L.C., Ebada, S.S., Stadler, M.*: Chemotaxonomic and molecular phylogenetic studies of Hypoxylon species based on teleomorphic traits. In: Mycology, 15, 2024, 1-16
2024Sum, W.C.; Ebada, S.S.; Kellner, H.; Stadler, M.: Comparative study of toxic terpenoidal aldehydes and lactone derivatives from the European polypore Bondarzewia mesenterica. In: ACS Omega, 9, 2024, 18668-18673
2024Pripdeevech, P.; Khruengsai, S.; Tanapichatsakul, C.; Afifi, W.M.; Sum, W.C.; Hyde, K.D.; Ebada, S.S. Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis. In: Journal of Natural Products, 87, 2024, 349-357
2024Elnaggar, M.S.; Fayez, S.; Anwar, A.; Ebada, S.S. Cytotoxic natpho- and benzofurans from an endophytic fungus Epicoccum nigrum Ann-B-2 associated with Annona squamosa fruits. In: Scientific Reports, 14, 2024,
2024Wennrich, J.-P., Holzenkamp, C., Kolařík, M., Maier, W., Mándi, A., Kurtán, T., Ashrafi, S., Ebada, S.S.,* Stadler, M.*: Dactylfungins and tetralones: Bioactive metabolites from a nematode-associated Laburnicola nematophila. In: Journal of Natural Products, 87, 2024, 1860–1871
2024Sum, W.C., Ebada, S.S., Ibrahim, M.A.A., Kellner, H., Stadler, M.*: Dentifragilones A–B and Other Benzoic Acid Derivatives from the European Basidiomycete Dentipellis fragilis. In: Molecules, 2024, 2859
2024Sum, W.C., Ebada, S.S., Muema, J.M., Kellner, H., Mándi, A., Kurtán, T., Stadler, M.*: Hermansones A and B: Bioactive naphthazrin congeners from the European crust fungus Hermanssonia centrifuga. In: Fitoterapia, 179, 2024, 106261
2024Wennrich, J.-P., Holzenkamp, C., Ashrafi, S., Maier, W., Wang, H., Ibrahim, M.A.A., Ebada, S.S.,* Stadler, M.*: Labunicolamine: A Rare Penillic Acid Congener from the Nematode Cyst-Associated Fungus Laburnicola nematophila. In: Chemistry and Biodiversity, 21, 2024, e202401152
2024Holzenkamp, C.; Wennrich, J.-P.; Muema, J. M.; Ashrafi, S.; Maier, W.; Stadler, M.;* Ebada S. S.*: Laburnicotides A–F: Acyclic N-acetyl Oligopeptides from the Nematode-Cyst Associated Fungus Laburnicola nematophila. In: ACS Omega, 9, 2024, 21658–21667
2024Phutthacharoen, K.; Toshe, R.; Khalid, S.J.; Llanos-López, N.A.; Wennrich, J.-P.; Schrey, H.; Ebada, S.S.; Hyde, K.D.; Stadler, M.: Lachnuoic acids A–F: Ambuic acid congeners from a saprotrophic Lachnum species (Ascomycota, Helotiales). In: Chemistry and Biodiversity, 21, 2024,
2024Charria-Girón, E., Sauer, C., García, D., Ebada, S.S.,* Marin-Felix, Y.*: Neochetracin: An unusual chetracin-type epithiodiketopiperazine derivative produced by the fungus Amesia atrobrunnea. In: ACS Omega, 9, 2024, 24009-24014
2024Sum, W.C., Gonkhom, D., Ibrahim, M.A.A., Stadler, M., Ebada, S.S.: New isoindolinone derivatives isolated from the fruiting bodies of the basidiomycete Hericium coralloides. In: Mycological Progress, 23, 2024, doi: 10.1007/s11557-023-01941-1
2024Wennrich, J.-P.; Ebada, S.S.; Sepanian, E.; Holzenkamp, C.; Khalid, S.J.; Schrey, H.; Maier, W.; Kurtán, T.; Ashrafi, S.; Stadler, M.: Omnipolyphilins A and B: novel chlorinated cyclotetrapeptides and naphtho-α-pyranones from two plant nematodederived fungi Polyphilus sieberi. In: Journal of Agricultural and Food Chemistry, 72, 2024, 6998–7009
2024Sum, W.C., Ebada, S.S.,* Wang, H., Kellner, H., Stadler, M.*: Protoilludene and Alkenoic Acid Derivatives from the European polypore Fomitiporia hartigii. In: ACS Omega, 9, 2024, 31006–31010
2024Sum, W.C., Ebada, S.S.,* Kellner, H., Stadler, M.*: p-Terphenyl and Orsellinic acid Derivatives from the European Polyporales Terana coerulea and Sparassis brevipes. In: Chemistry and Biodiversity, 21, 2024, e202401597
2023Wennrich, J.-P., Sepanian, E., Ebada, S.S., Llanos-Lopez, N.A., Ashrafi, S., Maier, W., Kurtán, T., Stadler, M.: Bioactive Naphtho-α-Pyranones from Two Endophytic Fungi of the Genus Polyphilus. In: Antibiotics, 12, 2023, 1273
2023Elnaggar, M.S., Ibrahim, N., Elissawy, A.M., Anwar, A., Ibrahim, M.A.A., Ebada, S.S.: Cytotoxic and antimicrobial mycophenolic acid derivatives from an endophytic fungus Penicillium sp. MNP-HS-2 associated with Macrozamia communis. In: Phytochemistry, 217, 2023, 113901
2023Phutthacharoen, K., Khalid, S.J., Schrey, H., Hyde, K.D., Stadler, M., Ebada, S.S.: Diaporphasines E and F: new polyketides from the saprotrophic fungus Lachnum sp. IW157 growing on the reed grass Phragmites communis. In: ACS Omega, 8, 2023, 41689–41695
2023Sum, W.C., Ebada, S.S., Kirchenwitz, M., Kellner, H., Ibrahim, M.A.A., Stradal, T.E.B., Matasyoh, J.C., Stadler, M.: Hericioic Acids A-G and Hericiofuranoic Acid; Neurotrophic Agents from Cultures of the European Mushroom Hericium flagellum. In: Journal of Agricultural and Food Chemistry, 71, 2023, 11094-11103
2023Khruengsai, S., Pripdeevech, P., Tanapichatsakul, C., Sum, W.C., Ibrahim, M.A.A., Stadler, M., Ebada, S.S.: Lasiodipline G and other diketopiperazine metabolites produced by Lasiodiplodia chiangraiensis. In: RSC Advances, 13, 2023, 19373-19378
2023Sum, W.C., Ebada, S.S., Kirchenwitz, M., Wanga, L.; Decock, C.; Stradal, T.E.B., Matasyoh, J.C., Mándi, A.; Kurtán, T.; Stadler, M.: Neurite outgrowth-inducing Drimane-type Sesquiterpenoids Isolated from Cultures of the Polypore Abundisporus violaceus MUCL 56355. In: Journal of Natural Products, 86, 2023, 2457-2467
2023Llanos-Lopez, N.A., Ebada, S.S., Vasco-Palacios, A.M., Sanchez-Giraldo, L.M., Lopez, L., Rojas, L.F., Mandi, A., Kurtán, T., Marin-Felix, Y.: Panapophenanthrin, a Rare Oligocyclic Diterpene from Panus strigellus. In: Metabolites, 13, 2023, 848
2023Elhefni, N., Ebada, S.S., Abdel-Aziz, M.M., Marwan, E.M.; El-Sharkawy, S. El-Neketi, M.: Promising anti-Helicobacterpylori and anti-inflammatory metabolites from unused parts of Phoenix dactylifera CV ′Zaghloul′: in vitro and in silico study. In: Pharmaceutical Biology, 61, 2023, 657-665
2023Sum, W.C., Ebada, S.S., Matasyoh, J.C., Stadler, M.: Recent progress in the evaluation of the secondary metaboiltes from Basidiomycota. In: Current Research in Biotechnology, 6, 2023, 100155
2023Eze, P.M., Simons, V.E., Frank, M., van Geelen, L., Abba, C.C., Ebada, S.S., Esimone, C.O., Okoye, Festus B.C., Proksch, P., Kalscheuer, R.: Serratiochelin D, a new siderophore from Serratia marcescens. In: Phytochemistry Letters, 57, 2023, 22-25
2023Sum, W.C., Ebada, S.S., Gonkhom, D., Decock, C., Teponno, R.B., Matasyoh, J.C., Stadler, M.: Two new lanostanoid glycosides isolated from a Kenyan polypore Fomitopsis carnea. In: Beilstein Journal of Organic Chemistry, 19, 2023, 1161-1169
2023Eze, P.M., Liu, Y., Simons, V.E., Ebada, S.S.; Kurtan, T., Kiraly, S.B., Esimone, C.O., Okoye, F.B.C., Proksch, P., Kalscheuer, R.: Two new metabolites from a marine-derived fungus Penicillium ochrochloron. In: Phytochemistry Letters, 55, 2023, 101-104
2022Uras I.S., Korinek M., Albohy A., Abdulrazik B.S., Lin W., Ebada S.S., Konuklugil B.: Anti-inflammatory, antiallergic, and COVID-19 main protease (Mpro) inhibitory activities of butenolides from a marine-derived fungus Aspergillus costaricaensis. In: ChemistrySelect, 2022,
2022Moustafa M., Zaghloul M.G., Sabry M.A., Aboelmaaty W.S., Hamed R.B., Ebada S.S., Ebrahim W.: Phytobiological investigation and in silico docking study of secondary metabolites from Saussurea lappa roots. In: ChemistrySelect, 7, 2022,
2022Capri S., Scoditti E., Polini B., Brogi S., Calderone V., Proksch P., Ebada S.S., Nieri P. Pro-apoptotic activity of the marine sponge Dactylospongia elegans metabolites pelorol and 5-epi-ilimaquinone on human 501Mel melanoma cells.. In: Marine Drugs, 20, 2022,
20212) Uras I.S., Ebada S.S., Korinek M., Albohy A., Abdulrazik B.S., Wang Y.-H., Chen B.-H., Horng J.-T., Lin W., Hwang T.-L., Konuklugil B.: Anti-inflammatory, antiallergic, and COVID-19 main protease (Mpro) inhibitory activities of butenolides from a marine-derived fungus Aspergillus terreus. In: Molecules, 2021,
2021Ebrahim, W., Ebada, S.S.: Antimicrobial metabolites from extremophilic fungus Botryotrichum piluliferum strain WESH19. In: Chemistry of Natural Compounds, 57, 2021, 654-658
2021Al-Tarabeen M., El-Neketi M., Albohy A., Müller W.E.G., Rasheed M., Ebrahim W., Proksch P., Ebada S.S.: Isolation and molecular docking of cytotoxic secondary metabolites from two Red Sea sponges of the genus Diacarnus. In: ChemistrySelect, 6, 2021, 217-220
2021Scoditti E., Naccarati A., Carpi S., Polini B., Ebada S.S., Nieri P.: Non-coding RNAs as mediators of the activity of natural compounds. In: Frontiers in Pharmacology, 12, 2021,
2021Pilevneli A.D., Ebada S.S., Kaşkatepe B., Konuklugil B.: Penicacids H-J, three new mycophenolic acid derivatives from the marine-derived fungus Rhizopus oryzae. In: RSC Advances, 11, 2021, 34938-34944
2020Ebada S.S., Al-Jawabri N.A., Youssef F.S., El-Kashef D.H., Knedel T.-O., Albohy A., Korinek M., Hwang T.-L., Chen B.-H., Lin G.-H., Lin C.-Y., Aldalaien S.M., Disi A.M., Janiak C., Proksch P.: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: Identification, structure-activity relationships, molecular modeling and impact on its folk medicinal uses. In: RSC Advances, 10, 2020, 38128-38141
2020Ebrahim W., Özkaya F.C., Ebada S.S.: Antifungal metabolites from endophytic fungus Fusarium verticillioides strain WF18. In: South African Journal of Botany, 133, 2020, 40-44
2020Orfali R., Ebrahim W., Perveen S., Majrashi N.M., Alluhayb K., Ebada S.S.: Cytotoxic secondary metabolites from mangrove-rhizosphere-associated fungus Emericella sp. Strain SWR1718. In: Journal of King Saud University - Science, 32, 2020, 2656-2661
2020Ebada S.S., Ebrahim W.: Quinoisobutyride A, an acyclic antibacterial tetrapeptide incorporating an unprecedented heterocyclic amino acid residue from the hypersaline lake-derived fungus Penicillium simplicissimum strain WSH17. In: Phytochemistry Letters, 36, 2020, 95-98
2019Ebada S.S., Müller W.E.G., Lin W., Proksch P.: New acyclic cytotoxic jasplakinolide derivative from the marine sponge Jaspis splendens. In: Marine Drugs, 17, 2019, 10.3390/md17020100
2019Elissawy A.M., Ebada S.S., Ashour M.L., El-Neketi M., Ebrahim W., Singab A.B.: New secondary metabolites from the mangrove-derived fungus Aspergillus sp. AV-2. In: Phytochemistry Letters, 29, 2019, 1-5
2018Ebada S.S., El-Neketi M., Ebrahim W., Mándi A., KurtánT., Kalscheuer R, Müller W.E.G., Proksch P.: Cytotoxic secondary metabolites from the endophytic fungus Aspergillus versicolor KU258497. In: Phytochemistry Letters, 24, 2018, 88-93
2018Marmouzi I., Tamsouri N., El Hamdani M., Attar A., El Bairi K., Kharbach M., Alami R., El Jemli M., CherrahY., Ebada S.S., Faouzi M.E.: Pharmacological and chemical properties of some marine echinoderms. In: Brazilian Journal of Pharmacongosy, 28, 2018, 575-581
2018Sekkien A., Swilam N., Ebada S.S., Esmat A., El-Khatib A.H., Linscheid M.W., Singab A.N.: Polyphenols from Tamarix nilotica: LC-ESI-MS profiling and in vivo antifibrotic activity. In: Molecules, 23, 2018, 1411
2018Talaat A.N., Ebada S.S., Labib R.M., Esmat A., Youssef F.S., Singab A.N.B.: Verification of the anti-inflammatory activity of the polyphenolic-rich fraction of Araucaria bidwillii Hook. using phytohaemagglutinin-stimulated human peripheral blood mononuclear cells and virtual screening. In: Journal of Ethnopharmacology, 224, 2018, 44-47
2017Youssef F.S., Ashour M.L., Ebada S.S., Sobeh M., El-Beshbishy H.A., Singab A.N., Wink M.: Antihyperglycaemic activity of the methanol extract from leaves of Eremophila maculata (Scrophluriaceae) in streptozotocin-induced diabetic rats. In: Journal of Pharmacy and Pharmacology, 69, 2017, 733-742
2017Al-Musayeib N., Ebada S.S., Gad H.A., Yousef F.S., Ashour M.L.: Chemotaxonomic diversity of three Ficus species, their discrimination using chemometric analysis and their role in combating oxidative stress. In: Pharmacognosy Magazine, 13, 2017, S613-S622
2017Ebada S.S., de Voogd N., Kalscheuer R., Müller W.E.G., Chaidir, Proksch P.: Cytotoxic drimane meroterpenoids from the Indonesian marine sponge Dactylospongia elegans. In: Phytochemistry Letters, 22, 2017, 154-158
2017Wätjen W., Ebada S.S., Bergermann A., Chovolou Y., Totzke F., Kubbutat M.H.G., Lin W., Proksch P. Cytotoxic effects of the anthraquinone derivatives 1’-deoxyrhodoptilometerin and (S)-(-)-rhodoptilomterin isolated from the marine echinoderm Comanthus sp.. In: Archives of Toxicology, 91, 2017, 1485-1495
2017Ebada S.S., Talaat A.N., Labib R.M., Mándi A., Kurtán T., Müller W.E.G., Singab A., Proksch, P.: Cytotoxic labdane diterpenes and bisflavonoid atropisomers from leaves of Araucaria bidwillii. In: Tetrahedron, 73, 2017, 3048-3055
2017Elissawy A.M., Ebada S.S., Ashour M.L., Özkaya F.C., Ebrahim W., Singab A.B., Proksch P. Spiroarthrinols A and B, two novel meroterpenoids isolated from the sponge derived fungus Arthrinium sp.. In: Phytochemistry Letters, 20, 2017, 246-251
2017Elnaggar M.S., Ebada S.S., Ashour M., Ebrahim W., Singab A.N.B., Lin W., Liu Z., Proksch P.: Two new triterpenoids and a new naphthaquinones derivative isolated from a hard coral-derived fungus Scopulariopsis sp.. In: Fitoterapia, 116, 2017, 126-130
2016El-Amrani M., Ebada S.S., Gad H.A., Proksch P.: Pestalotiopamide E and pestalotiopin B from an endophytic fungus Aureobasidium pullulans isolated from Aloe vera leaves. In: Phytochemistry Letters, 18, 2016, 95-98
2016Labib R.M., Ebada S.S., Youssef F.S., Ashour M.L., Ross S.A.: Ursolic acid, a natural pentacyclic triterpene from Ochrosia elliptica and its role in the management of certain neglected tropical diseases. In: Pharmacognosy Magazine, 2016, 2016, 2767–2771
2016Elnaggar M.S., Ebada S.S., Ashour M.L., Ebrahim W., Müller W.E.G., Mándi A., Kurtán T., Singab A., Lin W., Liu Z., Proksch P.: Xanthones and sesquiterpene derivatives from a marine-derived fungus Scopulariopsis sp.. In: Tetrahedron, 72, 2016, 2411-2419
2015Elissawy A.M., El-Shazly M., Ebada S.S., Singab A.N.B., Proksch P.: Bioactive terpenes from marine-derived fungi. In: Marine Drugs, 13, 2015, 1966-1992
2015Ebada S.S., Linh M.H., Longeon A., de Voogd N.J., Durieu E., Meijer L., Bourguet-Kondracki M.-L., Singab A.N.B., Müller W.E.G., Proksch P.: Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the Genus Stylissa. In: Natural Product Research, 29, 2015, 231-238
2014Ebada S.S., Fischer T., Hamacher A., Du F.-Y., Roth Y.O., Kassack M.U., Wang B.-G., Roth E.H.: Psychrophilin E from co-fermentation of two marine-derived fungi of the genus Aspergillus. In: Natural Product Research, 28, 2014, 776-781
2012Al-Oqail M.M., Al-Rehaily A.J., Hassan W.H.B., Ibrahim T.A., Ahmad M.S., Ebada S.S., Proksch P.: New flavonol glycosides from Barbeya oleoides Schweinfurth. In: Food Chemistry, 132, 2012, 2081–2088
2011Chovolou Y., Ebada S.S., Wätjen W., Proksch P.: Angular naphthopyrones from the Philippine echinoderm Comanthus sp. inhibit TNF-alpha-induced NF-κB activation. In: European Journal of Pharmacology, 657, 2011, 26–34
2011Ebada S.S., Schulz B., Wray V., Totzke F., Kubbutat M.H.G., Müller W.E.G., Hamacher A., Kassack M.U., Lin W., Proksch P.: Arthrinins A–D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.. In: Bioorganic and Medicinal Chemistry, 19, 2011, 4644–4651
2011Ebada S.S., Proksch P.: Chemistry and biology of guanidine alkaloids from marine invertebrates. In: MiniReviews in Medicinal Chemistry, 11, 2011, 225–246
2010Ebada S.S., Lin W., Proksch P.: Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance. In: Marine Drugs, 8, 2010, 313–346
2010Xu J., Ebada S.S., Proksch P.: Pestalotiopsis a highly creative genus: chemistry and bioactivity of secondary metabolites. In: Fungal Diversity, 44, 2010, 15–31
2009Orfali S.S., Ebada S.S., El-Shafae A.M., Al-Taweel A.M., Lin W.H., Wray V., Proksch P.: 3-O-trans-Caffeoylisomyricadiol: A new triterpenoid from Tamarix nilotica growing in Saudi Arabia. In: Zeitschrift für Naturforschung, 64c, 2009, 637–643
2009Ebada S.S., Edrada-Ebel R.A., de Voogd N.J., Wray V., Proksch P.: Dibromopyrrole alkaloids from the Marine Sponge Acanthostylotella sp.. In: Natural Product Communications, 4, 2009, 47–52
2009Ebada S.S., Wray V., de Voogd N.J., Deng Z., Lin W., Proksch P.: Two new jaspamide derivatives from the marine sponge Jaspis splendens. In: Marine Drugs, 7, 2009, 435–444
2008Ebada S.S., Edrada-Ebel R.A., Lin W., Proksch P.: Methods for isolation, purification and structural elucidation of bioactive secondary metabolites from marine invertebrates. In: Nature Protocols, 3, 2008, 1820–1831
200862) Ebada S.S., Ayoub N.A., Singab A.B., Al-Azizi M.A.: Phytophenolics from Peltophorum africanum Sond. (Fabaceae) with promising hepatoprotective activity. In: Pharmacognosy Magazine, 4, 2008, 286–292