Prof. Dr. Klaus Unsicker

Profile

Academic positionFull Professor
Research fieldsClinical Neurology; Neurosurgery and Neuroradiology,Developmental Neurobiology,Endocrinology, Diabetology, Metabolism

Current contact address

CountryGermany
CityFreiburg
InstitutionAlbert-Ludwigs-Universität Freiburg
InstituteInstitut für Anatomie und Zellbiologie

Host during sponsorship

Start of initial sponsorship01/01/1998

Programme(s)

1997Max Planck Research Award Programme

Publications (partial selection)

2001A. Roosen, A. Schober, J. Strelau, M. Böttner, J. Faulhaber, G. Bendner, S.L. McIlwrath, H. Seller, H. Ehmke, G.R. Lewin, K. Unsicker: Lack of NT-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation . In: J. Neuroscience, 2001, 3073-3084
2000D. Galter, K. Unsicker: Brain-derived neurotrophic and trkB anr essential for cAMP-mediated induction of the serotonergic neuronal phenotype. In: J. Neuroci. Res., 2000, 295-301
2000Klaus Unsicker, Kerstin Krieglstein: Co-activation of TGF-beta and cytokine signaling pathways are required for neurotrophic functions. In: Cytokine & Growth Factor Reviews, 2000, 97-102
2000A. Schober, U. Armäe, M. Saarma, K. Unsicker: Expression of GFRalpha-2, and c-Ret mRNA's in rat adrenal gland. In: J. Neurocytol., 2000, 209-213
2000B. Reuss, R. Hertel, S. Werner, K. Unsicker: Fibroblast growth factor-5 and -9 distinctly regulate expression and function of the gap junction protein connexin43 in cultured astroglial cells from different brain regions. In: GLIA, 2000, 231-241
2000J. Strelau, A. Sullivan, M. Böttner, P. Lingor, E. Falkenstein, C. Suter-Crazzolara, D. Galter, J. Jaszai, K. Krieglstein, K. Unsicker: GDF-15/MIC-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo. In: J. Neuroscience, 2000, 8597-8603
2000P. Lingor, K. Unsicker, K. Krieglstein: GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. In: Exp. Neurol., 2000, 55-62
2000P. Lingor, K. Unsicker, K. Krieglstein: Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application. In: J. Neural Transm., 2000, 139-144
2000S.E. Combs, K. Krieglstein, K. Unsicker: Reduction of endogenous TGF-beta increases proliferation of developing adrenal chromaffin cells in vivo. In: J. Neurosci. Res., 2000, 379-383
2000K. Krieglstein, S. Richter, L. Farkas, N. Schuster, N. Dünker, R. Oppenheim, K. Unsicker: Reduction of endogenous TGF-beta prevents ontogenetic neuron death. In: Nature neuroscience, 2000, 1085-1090
2000B. Reuss, D.S.Y. Leung, C. Ohlemeyer, H. Kettenmann, K. Unsicker: Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2. In: Mol. Cell. Neurosci., 2000, 781-792
2000Dagmar Galter and Klaus Unsicker: Sequential Activation of the 5-HT1A Serotonin Receptor and TrkB Induces the Serotonergic Neuronal Phenotype. In: Molecular and Cellular Neuroscience (MCN), 2000, 446-455
2000B. Reuss, K. Unsicker: Survival and differentiation of dopaminergic mesencephalic neurons are promoted by dopamine-mediated induction of FGF-2 in striatal astroglial cells. In: Mol. Cell. Neurosci., 2000, 781-792
1999Susetta Finotto, Kerstin Krieglstein, Andreas Schober, Frauke Deimling, Karin Lindner, Barbara Brühl, Konstantin Beier, Jürgen Metz, José L. Roig-Lopez, Paula Monaghan, Wolfgang Schmid, Timothy J. Cole, Christoph Kellendonk, Francois Tronche, Günter Schütz and Klaus Unsicker: Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. In: Development, 1999, 2935-2944
1999L. Farkas, J. Jaszai, K. Unsicker, K. Krieglstein: Characterization of bone morphogenetisc protein family members as neurotrophic factors for cultured sensory neurons. In: Neuroscience, 1999, 227-235
1999M. Böttner, M. Laaff, B. Schechinger, G. Rappold, K. Unsicker, C. Suter-Crazzolara: Characterization of the human, rat, and mouse genes of a novel TGF-beta superfamily member. In: Gene, 1999, 105-111
1999D. Galter, M. Böttner, K. Unsicker: Developmental regulation of the serotonergic transmitter phenotype in rostral and caudal raphe neurons by transforming growth factor-betas. In: J. Neuroscience Res. , 1999, 531-538
1999D. Galter, M. Böttner, K. Krieglstein, E. Schömig, K. Unsicker: Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins. In: Eur. J. Neuroscience, 1999, 2444-2452
1999Liliana Minichiello, Martin Korte, David Wolfer, Ralf Kühn, Klaus Unsicker, Vincenzo Cestari, Clelia Rossi-Arnaud, Hans-Peter Lipp, Tobias Bonhoeffer, and Rüdiger Klein: Essential Role for TrkB Receptors in Hippocampus-Mediated Learning. In: Neuron, 1999, 401-414
1999Martin Böttner, Clemens Suter-Crazzolara, Andreas Schober, Klaus Unsicker: Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissus. In: Cell Tissue Res, 1999, 103-110
1999A. Schober, N. Wolf, N. Kahane, C. Kalcheim, K. Krieglstein, K. Unsicker: Expression of neurotrophin receptors trkB and trkC and their ligands in rat adrenal gland and the intermediolateral column of the spinal cord. In: Cell Tiss. Res., 1999, 1-9
1999J. Strelau, K. Unsicker: GDNF family members and their receptors: Expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development. In: GLIA, 1999, 291-301
1999Andreas Schober, Richard Hertel, Urmas Arumäe, Lilla Farkas, Jozsef Jaszai, Kerstin Krieglstein, Mart Saarma, and Klaus Unsicker: Glial Cell Line-Derived Neurotrophic Factor Rescues Target-Deprived Sympathetic Spinal Cord Neurons But Requires Transforming Growth Factor-beta as Cofactor In Vito. In: The Journal of Neuroscience, 1999, 2008-2015
1999A. Schober, R. Hertel, U. Arumäe, L. Farkas, J. Jaszai, K. Krieglstein, M. Saarma, K. Unsicker: Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo. In: J. Neuroscience, 1999, 2008-2015
1999P. Lingor, K. Unsicker, K. Krieglstein: Growth/differentiation factor-5 (GDF-5) protects midbrain dopaminergic neurons from radical induced damage. In: J. Neural Transm., 1999, 139-144
1999Toshiyuki Motoike and Klaus Unsicker: Identification of a Potent Neurotrophic Substance for Ciliary Ganglionic Neurons in Fetal Calf Serum as Insulin-Like Growth Factor II. In: Journal of Neuroscience Research, 1999, 386-396
1999N. Wolf, K. Krohn, S. Brieger, M. Frödin, S. Gammeltroft, K. Krieglstein, K. Unsicker: Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary chromaffin cells. In: Neuroscience, 1999, 629-641
1998S. Bürvenich, K. Unsicker, K. Krieglstein: Calcitonin gene-related peptide (CGRP) promotes differentiation, but not survival of rat mesencephalic dopaminergic neurons in vitro. In: Neuroscience, 1998, 1165-1172
1998Frauke Deimling, Susetta Finotto, Karin Lindner, Barbara Brühl, Jose L. Roig-Lopez, Jose E. Garcia-Arraras, Christo Goridis, Kerstin Krieglstein, and Klaus Unsicker: Characterization of Adrenal Chromaffin Progenitor Cells in Mice. In: Advances in Pharmacology, 1998, 932-935
1998A. Schober, K. Huber, J. Fey, K. Unsicker: Distinct populations of macrophages in the adult rat adrenal gland: A subpopulation with neurotrophin-4 like immunoreactitivity. In: Cell Tiss. Res., 1998, 365-373
1998J. Jaszai, L. Farkas, D. Galter, B. Reuss, J. Strelau, K. Unsicker, K. Krieglstein: GDNF-related factor Persephin is widely distributed throughout the nervous system. In: J. Neuroscience Res., 1998, 494-501
1998B. Reuss, A. Heinke, K. Unsicker: Gap junction uncoupling of neonatal rat astroglial cultures does not affect the expression of fibroblast growth factor-2. In: Neuroscience Lett., 1998, 45-48
1998K. Krieglstein, P. Henheik, L. Farkas, J. Jaszai, D. Galter, K. Krohn, K. Unsicker: Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons. In: J. Neuroscience, 1998, 9822-9834
1998Jozsef Jaszai, Lilla Farkas, Dagmar Galter, Bernhard Reuss, Jens Strelau, Klaus Unsicker, and Kerstin Krieglstein: Rapid Communication GDNF-Related Factor Persephin Is Widely Distributed Throughout the Nervous System. In: Journal of Neuroscience Research, 1998, 494-501
1998D. Galter, K. Unsicker: Regulation of the transmitter phenotype of rostral and caudal groups of cultured serotonergic raphe neurons. In: Neuroscience, 1998, 549-559
1998K. Krieglstein, K. Unsicker: TGF-beta regulates survival of ciliary ganglionic neurons synergistically with ciliary neurotrophic factor and neurotrophins. In: J. Neurobiology, 1998, 563-572
1998K. Krieglstein, B. Reuss, D. Maysinger, K. Unsicker: Transforming growth factor-beta mediates the neurotrophic effect of fibroblast growth factor-2 on midbrain dopaminergic neurons. In: Eur. J. Neuroscience, 1998, 2746-2750
1998Andreas Schober, Nicole Wolf, Katrin Huber, Richard Hertel, Kerstin Krieglstein, Liliane Minichiello, Nitza Kahane, Johan Widenfalk, Chaya Kalcheim, Lars Olson, Rüdiger Klein, Gary R. Lewin, and Klaus Unsicker: TrkB and Neurotrophin-4 Are Important for Development and Maintenance of Sympathetic Preganglionic Neurons Innervating the Adrenal Medulla. In: The Journal of Neuroscience, 1998, 7272-7284