Prof. Dr. Klaus Unsicker

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietKlinische Neurologie; Neurochirurgie und Neuroradiologie,Entwicklungsneurobiologie,Endokrinologie, Diabetologie, Metabolismus

Aktuelle Kontaktadresse

LandDeutschland
OrtFreiburg
Universität/InstitutionAlbert-Ludwigs-Universität Freiburg
Institut/AbteilungInstitut für Anatomie und Zellbiologie

Gastgeber*innen während der Förderung

Beginn der ersten Förderung01.01.1998

Programm(e)

1997Max Planck-Forschungspreis-Programm

Publikationen (Auswahl)

2001A. Roosen, A. Schober, J. Strelau, M. Böttner, J. Faulhaber, G. Bendner, S.L. McIlwrath, H. Seller, H. Ehmke, G.R. Lewin, K. Unsicker: Lack of NT-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation . In: J. Neuroscience, 2001, 3073-3084
2000D. Galter, K. Unsicker: Brain-derived neurotrophic and trkB anr essential for cAMP-mediated induction of the serotonergic neuronal phenotype. In: J. Neuroci. Res., 2000, 295-301
2000Klaus Unsicker, Kerstin Krieglstein: Co-activation of TGF-beta and cytokine signaling pathways are required for neurotrophic functions. In: Cytokine & Growth Factor Reviews, 2000, 97-102
2000A. Schober, U. Armäe, M. Saarma, K. Unsicker: Expression of GFRalpha-2, and c-Ret mRNA's in rat adrenal gland. In: J. Neurocytol., 2000, 209-213
2000B. Reuss, R. Hertel, S. Werner, K. Unsicker: Fibroblast growth factor-5 and -9 distinctly regulate expression and function of the gap junction protein connexin43 in cultured astroglial cells from different brain regions. In: GLIA, 2000, 231-241
2000J. Strelau, A. Sullivan, M. Böttner, P. Lingor, E. Falkenstein, C. Suter-Crazzolara, D. Galter, J. Jaszai, K. Krieglstein, K. Unsicker: GDF-15/MIC-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo. In: J. Neuroscience, 2000, 8597-8603
2000P. Lingor, K. Unsicker, K. Krieglstein: GDNF and NT-4 protect midbrain dopaminergic neurons from toxic damage by iron and nitric oxide. In: Exp. Neurol., 2000, 55-62
2000P. Lingor, K. Unsicker, K. Krieglstein: Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application. In: J. Neural Transm., 2000, 139-144
2000S.E. Combs, K. Krieglstein, K. Unsicker: Reduction of endogenous TGF-beta increases proliferation of developing adrenal chromaffin cells in vivo. In: J. Neurosci. Res., 2000, 379-383
2000K. Krieglstein, S. Richter, L. Farkas, N. Schuster, N. Dünker, R. Oppenheim, K. Unsicker: Reduction of endogenous TGF-beta prevents ontogenetic neuron death. In: Nature neuroscience, 2000, 1085-1090
2000B. Reuss, D.S.Y. Leung, C. Ohlemeyer, H. Kettenmann, K. Unsicker: Regionally distinct regulation of astroglial neurotransmitter receptors by fibroblast growth factor-2. In: Mol. Cell. Neurosci., 2000, 781-792
2000Dagmar Galter and Klaus Unsicker: Sequential Activation of the 5-HT1A Serotonin Receptor and TrkB Induces the Serotonergic Neuronal Phenotype. In: Molecular and Cellular Neuroscience (MCN), 2000, 446-455
2000B. Reuss, K. Unsicker: Survival and differentiation of dopaminergic mesencephalic neurons are promoted by dopamine-mediated induction of FGF-2 in striatal astroglial cells. In: Mol. Cell. Neurosci., 2000, 781-792
1999Susetta Finotto, Kerstin Krieglstein, Andreas Schober, Frauke Deimling, Karin Lindner, Barbara Brühl, Konstantin Beier, Jürgen Metz, José L. Roig-Lopez, Paula Monaghan, Wolfgang Schmid, Timothy J. Cole, Christoph Kellendonk, Francois Tronche, Günter Schütz and Klaus Unsicker: Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. In: Development, 1999, 2935-2944
1999L. Farkas, J. Jaszai, K. Unsicker, K. Krieglstein: Characterization of bone morphogenetisc protein family members as neurotrophic factors for cultured sensory neurons. In: Neuroscience, 1999, 227-235
1999M. Böttner, M. Laaff, B. Schechinger, G. Rappold, K. Unsicker, C. Suter-Crazzolara: Characterization of the human, rat, and mouse genes of a novel TGF-beta superfamily member. In: Gene, 1999, 105-111
1999D. Galter, M. Böttner, K. Unsicker: Developmental regulation of the serotonergic transmitter phenotype in rostral and caudal raphe neurons by transforming growth factor-betas. In: J. Neuroscience Res. , 1999, 531-538
1999D. Galter, M. Böttner, K. Krieglstein, E. Schömig, K. Unsicker: Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins. In: Eur. J. Neuroscience, 1999, 2444-2452
1999Liliana Minichiello, Martin Korte, David Wolfer, Ralf Kühn, Klaus Unsicker, Vincenzo Cestari, Clelia Rossi-Arnaud, Hans-Peter Lipp, Tobias Bonhoeffer, and Rüdiger Klein: Essential Role for TrkB Receptors in Hippocampus-Mediated Learning. In: Neuron, 1999, 401-414
1999Martin Böttner, Clemens Suter-Crazzolara, Andreas Schober, Klaus Unsicker: Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissus. In: Cell Tissue Res, 1999, 103-110
1999A. Schober, N. Wolf, N. Kahane, C. Kalcheim, K. Krieglstein, K. Unsicker: Expression of neurotrophin receptors trkB and trkC and their ligands in rat adrenal gland and the intermediolateral column of the spinal cord. In: Cell Tiss. Res., 1999, 1-9
1999J. Strelau, K. Unsicker: GDNF family members and their receptors: Expression and functions in two oligodendroglial cell lines representing distinct stages of oligodendroglial development. In: GLIA, 1999, 291-301
1999Andreas Schober, Richard Hertel, Urmas Arumäe, Lilla Farkas, Jozsef Jaszai, Kerstin Krieglstein, Mart Saarma, and Klaus Unsicker: Glial Cell Line-Derived Neurotrophic Factor Rescues Target-Deprived Sympathetic Spinal Cord Neurons But Requires Transforming Growth Factor-beta as Cofactor In Vito. In: The Journal of Neuroscience, 1999, 2008-2015
1999A. Schober, R. Hertel, U. Arumäe, L. Farkas, J. Jaszai, K. Krieglstein, M. Saarma, K. Unsicker: Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo. In: J. Neuroscience, 1999, 2008-2015
1999P. Lingor, K. Unsicker, K. Krieglstein: Growth/differentiation factor-5 (GDF-5) protects midbrain dopaminergic neurons from radical induced damage. In: J. Neural Transm., 1999, 139-144
1999Toshiyuki Motoike and Klaus Unsicker: Identification of a Potent Neurotrophic Substance for Ciliary Ganglionic Neurons in Fetal Calf Serum as Insulin-Like Growth Factor II. In: Journal of Neuroscience Research, 1999, 386-396
1999N. Wolf, K. Krohn, S. Brieger, M. Frödin, S. Gammeltroft, K. Krieglstein, K. Unsicker: Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary chromaffin cells. In: Neuroscience, 1999, 629-641
1998S. Bürvenich, K. Unsicker, K. Krieglstein: Calcitonin gene-related peptide (CGRP) promotes differentiation, but not survival of rat mesencephalic dopaminergic neurons in vitro. In: Neuroscience, 1998, 1165-1172
1998Frauke Deimling, Susetta Finotto, Karin Lindner, Barbara Brühl, Jose L. Roig-Lopez, Jose E. Garcia-Arraras, Christo Goridis, Kerstin Krieglstein, and Klaus Unsicker: Characterization of Adrenal Chromaffin Progenitor Cells in Mice. In: Advances in Pharmacology, 1998, 932-935
1998A. Schober, K. Huber, J. Fey, K. Unsicker: Distinct populations of macrophages in the adult rat adrenal gland: A subpopulation with neurotrophin-4 like immunoreactitivity. In: Cell Tiss. Res., 1998, 365-373
1998J. Jaszai, L. Farkas, D. Galter, B. Reuss, J. Strelau, K. Unsicker, K. Krieglstein: GDNF-related factor Persephin is widely distributed throughout the nervous system. In: J. Neuroscience Res., 1998, 494-501
1998B. Reuss, A. Heinke, K. Unsicker: Gap junction uncoupling of neonatal rat astroglial cultures does not affect the expression of fibroblast growth factor-2. In: Neuroscience Lett., 1998, 45-48
1998K. Krieglstein, P. Henheik, L. Farkas, J. Jaszai, D. Galter, K. Krohn, K. Unsicker: Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons. In: J. Neuroscience, 1998, 9822-9834
1998Jozsef Jaszai, Lilla Farkas, Dagmar Galter, Bernhard Reuss, Jens Strelau, Klaus Unsicker, and Kerstin Krieglstein: Rapid Communication GDNF-Related Factor Persephin Is Widely Distributed Throughout the Nervous System. In: Journal of Neuroscience Research, 1998, 494-501
1998D. Galter, K. Unsicker: Regulation of the transmitter phenotype of rostral and caudal groups of cultured serotonergic raphe neurons. In: Neuroscience, 1998, 549-559
1998K. Krieglstein, K. Unsicker: TGF-beta regulates survival of ciliary ganglionic neurons synergistically with ciliary neurotrophic factor and neurotrophins. In: J. Neurobiology, 1998, 563-572
1998K. Krieglstein, B. Reuss, D. Maysinger, K. Unsicker: Transforming growth factor-beta mediates the neurotrophic effect of fibroblast growth factor-2 on midbrain dopaminergic neurons. In: Eur. J. Neuroscience, 1998, 2746-2750
1998Andreas Schober, Nicole Wolf, Katrin Huber, Richard Hertel, Kerstin Krieglstein, Liliane Minichiello, Nitza Kahane, Johan Widenfalk, Chaya Kalcheim, Lars Olson, Rüdiger Klein, Gary R. Lewin, and Klaus Unsicker: TrkB and Neurotrophin-4 Are Important for Development and Maintenance of Sympathetic Preganglionic Neurons Innervating the Adrenal Medulla. In: The Journal of Neuroscience, 1998, 7272-7284