Prof. Dr. Azefack Leon Tapondjou

Profile

Academic positionFull Professor
Research fieldsNatural Product Chemistry,Pharmacy
Keywordsmedicinal plants, saponins, isolation, characterisation, tumor therapy

Current contact address

CountryCameroon
CityDschang
InstitutionUniversite de Dschang
InstituteFaculty of Sciences, Department of Chemistry

Host during sponsorship

Prof. Dr. Dr. Matthias MelzigInstitut für Pharmazie, Freie Universität Berlin, Berlin
Prof. Dr. Till OpatzDepartment Chemie, Johannes Gutenberg-Universität Mainz, Mainz
Prof. Dr. Azefack Leon TapondjouFaculty of Sciences, Department of Chemistry, Universite de Dschang, Dschang
Start of initial sponsorship01/05/2012

Program(s)

2010Georg Forster Research Fellowship Programme for Experienced Researchers

Publications (partial selection)

2015 Djouossi M. G., Tamokou J. D., Ngnokam D., Kuiate J. R., Tapondjou A. L., Harakat D., Voutquenne N., L. : Antimicrobial and antioxidant flavonoids from leaves of Oncoba spinosa Forssk. (Salicaceae) . In: BMC complementary Alternative Medecine , 2015, 134
2015 Tchegnitegni B. T., Teponno R. B., Tanaka C., Adeyemi F. G., Tapondjou A. L., Miyamoto T.,: Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain. In: Phytochemistry Letters , 2015, 262-266
2015Tapondjou, A. L.; Siems J. K.; Böttger, S.; Melzig F. M.: Steroidal saponins from the mesocarp of the fruits of Raphia farinifera (Gaertn.)Hyl. (Arecaceae) and their cytotoxic activity, . In: Natural Product Communications , 2015,
2014 Nono N. R. Barboni L., Teponno R. B., Quassinti L., Bramussi M., Vitali L. A., Petreli D., Lupidi G., Tapondjou A. L. : Antimicrobial, antioxidant, anti-inflammatory activities and phytoconstituents of extracts from the roots of Dissotis thollonii Cogn. (Melastomataceae), . In: South African Journal of Botany , 2014, 19-26
2014 Nono N. R., Kegha N. L., Barboni L., Tapondjou A. L. Drymaria cordata Linn. (Willd) (Caryophyllaceae): Ethnobotany, Pharmacology and Phytochemistry, Advance in Biological Chemistry . In: Advance in Biological Chemistry , 2014, 160-167
2014 Fouedjou T. R., Teponno R. B., Quassinti L., Bramussi M.. Petreli D., Vitali L. A., Fiorini D., Tapondjou A. L. Barboni L. : Steroidal saponins from leaves of Cordyline fruticosa (L.) A. Chev. and their cytotoxic and antimicrobial activity . In: Phytochemistry Letters , 2014, 62-68
2013 Teponno, R.B.; Ponou, K. B.; Tapondjou A. L.; Barboni, L.: Bafoudiosbulbin H, a new clerodane diterpene from the flowers of Dioscorea bulbifera L. var sativa . In: Phytochemistry Letters, 6, 310-314 , 2013, 310-314
2013 Teponno, R.B.; Ponou, K. B.; Florrini D., Barboni L., Tapondjou A. L: Chemical constituents from the roots of Furcraea bedinghausii Koch., . In: International Letters of Chemistry, Physics and Astronomy , 2013, 9-19
2013 Tapondjou, A. L.; Siems J. K.; Böttger, S.; Melzig F. M.: New steroidal saponins from the flowers of Dioscorea bulbifera var. sativa . In: Phytochemistry , 2013, 341-350
2013 Noté, O. L., Tapondjou, A. L., Mitaine-Offer, A.C., Miyamoto, T., Pegnyemb, E. D. Lacaille- Dubois, M.A : Triterpenoid saponins from Africanum piptadeniastrum (Hook f.) Brenan. . In: Phytochemistry Letters, 2013, 505-510
2013Nzowa, K. L.; Teponno, R.B.; Tapondjou, A.L.; Verotta, L.; Liao, Z.; Graham, D.; Zink M. C.; L. Barboni, L. : Two new tryptophan derivatives from the seed kernels of Entada rheedei: Effects on cell viability and HIV infectivity . In: Fitoterapia , 2013, 37-42
2012 Kuete, V.; Teponno, R. B.; Tsafack M. A.; Tapondjou A. L.; Meyer J. J. M.; Barboni L.; Lall N. Antibacterial activities of the extracts, fractions and compounds from Dioscorea bulbifera, . In: BMC Complementary and Alternative Medicine , 2012, 228
2011 Tapondjou, A.L.; Tankeu Nyaa L.B.; Tane P; Ricciutelli, M.; Quassinti L.; Bramucci, M.; Lupidi, G.; Ponou, K. B; Barboni, L : Parkioside A-C, Triterpene saponins from Butyrospermum parkii (Sapotaceae), . In: Carbohydrates Research, 2011, 2699-2704
2011 Mbiantcha M., Nkamanyi A., Teponno R. B., Tapondjou A. L., Watcho P., Nguelefack T. B. Analgesic and anti-inflammatory properties of extracts from bubils of Dioscorea bulbifera L. var. sativa (Dioscoreaceae) in mices and rats . In: Evidence-based Complementary and alternative Medecine, , 2011, 1-9
2011 Teke, G. N., Kuiaté, J. R., Kueté, V., Teponno, R. B., Tapondjou, A. L., Tane Pierre, Giacinti G. Vilerem, G. : Bio-guided Isolation of potential antimicrobial and antioxidant agents the stem bark of Trilepisium madagascariense, . In: South African Journal of Botany , 2011, 319-327
2011 Nguelefack T. B., Mbakam K. F. H., Tapondjou A. L., Watcho, P. ;, Mbuyo Pami Nguelefack E., Ponou K. B., Kamanyi, A., Park H.J., Dimeric saponin and Flavonoids with Free Radical Scavenging Activity Isolated from Rubus rigidus var. Camerunensis . In: Archives of Pharmacal Research , 2011, 543-550
2011 Ponou, K. B; Teponno, R. B.; Ricciutelli, M.; Nguelefack T.B.; Quassinti L.; Bramucci, M.; Lupidi, G.; Barboni, L.; Tapondjou, A.L : Novel 3-oxo and 3,24-dinor-2,4- seco-oleanane- type triterpenes from Terminalia ivorensis A. Chev . In: Chemistry and Biodiversitry, 2011, 1301-1309
2010 Teke, G. N., Kuiaté, J. R., Kueté, V., Teponno, R. B., Tapondjou, A. L., Vilerem, Antidarrheal activity of extracts and compounds from Trilepisium madagascariense stem bark, . In: Indian Journal of Pharmacology , 2010, 157-163
2010 -Nguelefack, T. B, Dutra, R. C., Paszcuk,A. F., Andrade, E. L., Tapondjou, A. L., Calixto, J., B. : Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L., var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K+ channel activation, . In: Journal of Ethnopharmacology , 2010, 567-574
2010 Nzedong Tigoufack I. B., Ngnokam D., Tapondjou A.L., Harakat D., Voutquenne L.: Cycloartane glycosides from leaves of Oxyanthus pallidus. In: Phytochemistry 71, 2182-2186., 2010, 2182-2186
2010 Ponou, K. B, Teponno, R. B., Ricciutelli, M., Quassinti L., Bramucci, M., Lupidi, G., Barboni, L., Tapondjou, A.L. : Dimeric antioxidant and cytotoxic triterpenoid saponins from Terminalia ivorensis A. Chev. . In: Phytochemistry , 2010, 2108-2115
2010 Nzowa, K.L, Barboni, L., Teponno, R. B., Ricciutelli, M., Lupidi, G., Quassinti L., Bramucci M., Tapondjou, A.L. : Rheediinosides A and B, two antiproliferative and antioxidant triterpene saponins from Entada rheedii . In: Phytochemistry , 2010, 254-261
2009 Tankeu Nyaa L. B., Tapondjou A. L., Barboni L., Tamokou J. D., Kuiaté J. R., Tane P. Park H. J. : NMR Assignment and Antimicrobial/Antioxidant Activities of 1β-Hydroxyeuscaphic acid from the Seeds of Butyrospermum parkii . In: Natural Product Science, 2009, 76-82
2008 Teponno, R. B., Tapondjou, A.L., Abou-Mansour, E., Stoekli-Evans, H., Tane, P., Barboni, L: Bafoudiosbulbins F and G, further clerodane diterpenoids from Dioscorea bulbifera L. var sativa and revised structure of Bafoudiosbulbin B . In: Phytochemistry , 2008, 2374-2379
2008 Tapondjou, A.L., Ponou, K. B.,Teponno, R.B., Mbiantcha, M., Djoukeng, J.D., Nguelefack, T., B., Watcho, P., Gomez-Cadenas, A. and Park, H.J : In Vivo Anti-Inflammatory Effect of a New Steroidal Saponin, Mannioside A, and Its Derivatives Isolated from Dracaena mannii, . In: Archives of Pharmacal Research , 2008, 653-658
2008 Ponou, K. B., Barboni, L., Teponno, R.B., Mbiantcha, M., Nguelefack, T., B., Park, H.J., Lee Kyung T., Tapondjou, A.L., : Polyhydroxyoleanane –type triterpenoids from Combretum molle and their anti-inflammatory activity. . In: Phytochemistry Letters , 2008, 183-187
2007 Nam, J.H., Jung, H.J., Tapondjou, A.L., Lee, K.T., Choi, J., Kim, W.B. and Park,H.J. The anti-hyperlipidemic effects and constituents of the 19α-hydroxyursane-type triterpenoid fraction obtained from the leaves of Rubus crataegifolius. . In: Natural Product Sciences , 2007, 152-159
2007 Djoukeng, J.D., Abou-Mansour, E., Tapondjou, A.L., Lontsi, D and Tabacchi, R.: Identification of Ellagic acid derivatives from stem bark of Syzygium guineense (Myrtaceae). . In: Natural Product Communications, 2007, 261-266
2007 Teponno, R. B., Tapondjou, A.L., Jung, H.J., Nam, J.H., Tane, P. and Park, H. J. Three new clerodane diterpenoids from the bubils of Dioscorea bulbifera var. sativa. In: Helvetica Chimica Acta , 2007, 1599-1605
2006 Nguelefack, T.B, Nana, P., Atsamo, A. D., Dimo, T., Watcho, P., Dongmo, A. B., Tapondjou, A. L., Njamen D., Wansi S.L.and Kamanyi A.( : Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae). . In: Journal of Ethnopharmacology , 2006, 70-75
2006 Teponno, R. B., Tapondjou, A.L., Gatsing, D., Djoukeng, J.D., Abou-Mansour, E.,Tabacchi, R., Tane, P., Stoekli-Evans, H., Lontsi D. and Park, H. J. : Bafoudiosbulbins A and B, two antisalmonellal clerodane diterpenoids from Dioscorea bulbifera var. sativa. . In: Phytochemistry , 2006, 1957-1963
2006 Tapondjou A. L., Miyamoto T. and Lacaille-Dubois M. A: Glucuronide triterpene saponins from Bersama engleriana. . In: Phytochemistry , 2006, 2126-2132
2006 Teponno, R. B., Tapondjou, A.L., Djoukeng, J.D., Abou-Mansour, E., Tabacchi, R., Tane, P., Lontsi, D. and Park, H. J. : Isolation and NMR assignment of a Pennogenin glycoside from Dioscorea bulbifera var sativa. . In: Natural Product Sciences, 2006, 62-66
2006 Tapondjou, A. L., Mitaine-Offer, A.C., Miyamoto, T., Lerche, H., Mirjolet, J.F., Nicolas Guilbaud, N. and Lacaille-Dubois, M.A : Triterpene saponins from Schefflera abyssinica. . In: Biochemical Systematics and Ecology , 2006, 887-889
2005 Tapondjou, A.L., Makmoor, T., Lontsi, D., Sondengam, B.L.,Choudhary, M.I.and Atta-ur- Rahman. : A new antioxidant caffeoyl derivative from Cussonia bancoensis. . In: Cameroon Journal of Experimental Biology , 2005, 57-61
2005 Djoukeng, J. D., Abou-Mansour, E., Tabacchi, R., Tapondjou, A. L., Bouda, H. and Lontsi, D.: Antibacterial triterpenes from Syzygium guineense (Myrtaceae). In: Journal of Ethnopharmacology , 2005, 283-286
2005 Ngounou F.N., Manfouo R.N., Tapondjou A.L., Lontsi D., Kuete V., Penlap V., Etoa F.X., Lacaille Dubois M.A.and Sondengam B.L. : Antimicrobial Diterpenoid alkaloids from Erythropleum suaveolens (Guill & Perr.) Brenan. . In: Bulletin of the Chemical Society of Ethiopia 19, 221-226. , 2005, 221-226
2005 Tapondjou, A. L, Miyamoto, T., Mirjolet J.F, Guilbaud, N. Lacaille-Dubois, M. A.: Pursaethosides A-E, Triterpenes Saponins from Entada pursaetha. In: Journal of Natural Products , 2005, 1185-1190
2005Tapondjou, A.L., Mitaine-Offer, A.C., Sautour, M., Miyamoto, T. and Lacaille Dubois, M.A. Sphingolipids and other constituents from Cordia platythyrsa. Biochemical Systematics and Ecology . In: Biochemical Systematics and Ecology , 2005, 1293-1297
2004 Mitaine-Offer, A.C., Tapondjou, A.L., Lontsi, D., Sondengam, B.L., Choudhary, M.I., Atta- ur-Rahman and Lacaille-Dubois, M. A : Constituents isolated from Polyscias fulva.. In: Biochemical Systematics and Ecology , 2004, 607-610
2004 Shin, K. M., Kim, R.K. Tapondjou, A.L., Lontsi D., Sondengam B. L., Choudhary, M.I., Park, H. J., Choi, J., Lee, K. T. : In vitro Antiinflammatory Activity of 23-Hydroxyursolic Acid Isolated from Cussonia bancoensis in Murine Macrophage Raw 264.7 Cells . In: Planta Medica , 2004, 803-807
2003 Mitaine-Offer, A.. C., Djoukeng, J. D., Tapondjou, A.L, Bouda, H., Lerche, H., Lontsi, D. and Lacaille-Dubois, M. A. : Constituents of the leaves of Eucalyptus Saligna.. In: Biochemical Systematics and Ecology, 2003, 1457-1460
2003 Mitaine-Offer, A.G., Tapondjou, A. L, Djoukeng, J. D., Bouda, H. and Dubois Lacaille, M.A. Derivatives of Scopoletin and -sitosterol from Hymenodictyon floribundum. In: Biochemical Systematics and Ecology , 2003, 227-228
2003 Tapondjou, A.L, Lontsi, D., Sondengam, B.L., Choi, J., Lee, K.T., Jung, H. J. and Park, H. J. In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid from Cussonia bancoensis . In: Archives of Pharmacal Research , 2003, 143-146
2003 Tapondjou, A.L., Lontsi, D., Sondengam, B. L., Fazarna S., Choudhary, M.I., Atta-ur-Rahman, Heerden, F.R., Park, H.,J., and Lee, K. L : Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production . In: Journal of Natural Products , 2003, 1266-1269
2002 Fatima, N., Tapondjou, A.L., Lontsi, D., Sondengam, B.L.,Atta-ur-Rahman and Choudhary, M.I. : Quinovic acid glycosides from Mitragyna stipulosa-First examples of natural inhibitors of snake venom phosphodiesterase I. . In: Natural Product Letters, 2002, 389-393
2002 Tapondjou, A.L., Lontsi,D., Sondengam, B.L., Choudhary, M.I., Park, H.J., Choi, J. and Lee, K.T.: Structure-activity relationship of triterpenoids isolated from Mitragyna stipulosa on cytotoxicity. . In: Archives of Pharmacal Research , 2002, 270-274
2002 Tapondjou, A.L., David Lontsi, D., Bouda, H., Sondengam, B. L., Atta-ur-Rahman, Choudhary, M. I. and Heerden, F. R. : Zemoside A, A new ursane type saponin from Cussonia bancoensis . In: ACGC Chemical Research Communications , 2002, 11-19
1998 Tapondjou A. L., Ngounou F.N., Lontsi D., Sondengam B. L. and Connolly J. D: Reactions of 2, 3, 19-trihydroxyurs-12-en-triterpenoids: Pinacol Rearrangement of methyl 2, 3, 19-trihydroxy-12-en-28-oate. . In: Tetrahedron. , 1998, 2099-2106
1998 Lontsi, D., Ngounou, F.N.,Tapondjou, A.L., Sondengam,B.L., Bodo, B. and Martin, M.T: An E-ring -lactone pentacyclic triterpenes from Myrianthus serratus.. In: Phytochemistry , 1998, 2473-2476
1995 Tapondjou, A.L, Ngounou, N. F., Lontsi, D., Sondengam, B.L., Martin, M.T. and Bodo, B: Pentacyclic triterpenes from Myrianthus liberecus. . In: Phytochemistry , 1995, 1761-1764