Prof. Dr. Azefack Leon Tapondjou

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietNaturstoffchemie,Pharmazie
Keywordsmedicinal plants, saponins, isolation, characterisation, tumor therapy

Aktuelle Kontaktadresse

LandKamerun
OrtDschang
Universität/InstitutionUniversite de Dschang
Institut/AbteilungFaculty of Sciences, Department of Chemistry

Gastgeber*innen während der Förderung

Prof. Dr. Dr. Matthias MelzigInstitut für Pharmazie, Freie Universität Berlin, Berlin
Prof. Dr. Till OpatzDepartment Chemie, Johannes Gutenberg-Universität Mainz, Mainz
Prof. Dr. Azefack Leon TapondjouFaculty of Sciences, Department of Chemistry, Universite de Dschang, Dschang
Beginn der ersten Förderung01.05.2012

Programm(e)

2010Georg Forster-Forschungsstipendien-Programm für erfahrene Forschende

Publikationen (Auswahl)

2015 Djouossi M. G., Tamokou J. D., Ngnokam D., Kuiate J. R., Tapondjou A. L., Harakat D., Voutquenne N., L. : Antimicrobial and antioxidant flavonoids from leaves of Oncoba spinosa Forssk. (Salicaceae) . In: BMC complementary Alternative Medecine , 2015, 134
2015 Tchegnitegni B. T., Teponno R. B., Tanaka C., Adeyemi F. G., Tapondjou A. L., Miyamoto T.,: Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain. In: Phytochemistry Letters , 2015, 262-266
2015Tapondjou, A. L.; Siems J. K.; Böttger, S.; Melzig F. M.: Steroidal saponins from the mesocarp of the fruits of Raphia farinifera (Gaertn.)Hyl. (Arecaceae) and their cytotoxic activity, . In: Natural Product Communications , 2015,
2014 Nono N. R. Barboni L., Teponno R. B., Quassinti L., Bramussi M., Vitali L. A., Petreli D., Lupidi G., Tapondjou A. L. : Antimicrobial, antioxidant, anti-inflammatory activities and phytoconstituents of extracts from the roots of Dissotis thollonii Cogn. (Melastomataceae), . In: South African Journal of Botany , 2014, 19-26
2014 Nono N. R., Kegha N. L., Barboni L., Tapondjou A. L. Drymaria cordata Linn. (Willd) (Caryophyllaceae): Ethnobotany, Pharmacology and Phytochemistry, Advance in Biological Chemistry . In: Advance in Biological Chemistry , 2014, 160-167
2014 Fouedjou T. R., Teponno R. B., Quassinti L., Bramussi M.. Petreli D., Vitali L. A., Fiorini D., Tapondjou A. L. Barboni L. : Steroidal saponins from leaves of Cordyline fruticosa (L.) A. Chev. and their cytotoxic and antimicrobial activity . In: Phytochemistry Letters , 2014, 62-68
2013 Teponno, R.B.; Ponou, K. B.; Tapondjou A. L.; Barboni, L.: Bafoudiosbulbin H, a new clerodane diterpene from the flowers of Dioscorea bulbifera L. var sativa . In: Phytochemistry Letters, 6, 310-314 , 2013, 310-314
2013 Teponno, R.B.; Ponou, K. B.; Florrini D., Barboni L., Tapondjou A. L: Chemical constituents from the roots of Furcraea bedinghausii Koch., . In: International Letters of Chemistry, Physics and Astronomy , 2013, 9-19
2013 Tapondjou, A. L.; Siems J. K.; Böttger, S.; Melzig F. M.: New steroidal saponins from the flowers of Dioscorea bulbifera var. sativa . In: Phytochemistry , 2013, 341-350
2013 Noté, O. L., Tapondjou, A. L., Mitaine-Offer, A.C., Miyamoto, T., Pegnyemb, E. D. Lacaille- Dubois, M.A : Triterpenoid saponins from Africanum piptadeniastrum (Hook f.) Brenan. . In: Phytochemistry Letters, 2013, 505-510
2013Nzowa, K. L.; Teponno, R.B.; Tapondjou, A.L.; Verotta, L.; Liao, Z.; Graham, D.; Zink M. C.; L. Barboni, L. : Two new tryptophan derivatives from the seed kernels of Entada rheedei: Effects on cell viability and HIV infectivity . In: Fitoterapia , 2013, 37-42
2012 Kuete, V.; Teponno, R. B.; Tsafack M. A.; Tapondjou A. L.; Meyer J. J. M.; Barboni L.; Lall N. Antibacterial activities of the extracts, fractions and compounds from Dioscorea bulbifera, . In: BMC Complementary and Alternative Medicine , 2012, 228
2011 Tapondjou, A.L.; Tankeu Nyaa L.B.; Tane P; Ricciutelli, M.; Quassinti L.; Bramucci, M.; Lupidi, G.; Ponou, K. B; Barboni, L : Parkioside A-C, Triterpene saponins from Butyrospermum parkii (Sapotaceae), . In: Carbohydrates Research, 2011, 2699-2704
2011 Mbiantcha M., Nkamanyi A., Teponno R. B., Tapondjou A. L., Watcho P., Nguelefack T. B. Analgesic and anti-inflammatory properties of extracts from bubils of Dioscorea bulbifera L. var. sativa (Dioscoreaceae) in mices and rats . In: Evidence-based Complementary and alternative Medecine, , 2011, 1-9
2011 Teke, G. N., Kuiaté, J. R., Kueté, V., Teponno, R. B., Tapondjou, A. L., Tane Pierre, Giacinti G. Vilerem, G. : Bio-guided Isolation of potential antimicrobial and antioxidant agents the stem bark of Trilepisium madagascariense, . In: South African Journal of Botany , 2011, 319-327
2011 Nguelefack T. B., Mbakam K. F. H., Tapondjou A. L., Watcho, P. ;, Mbuyo Pami Nguelefack E., Ponou K. B., Kamanyi, A., Park H.J., Dimeric saponin and Flavonoids with Free Radical Scavenging Activity Isolated from Rubus rigidus var. Camerunensis . In: Archives of Pharmacal Research , 2011, 543-550
2011 Ponou, K. B; Teponno, R. B.; Ricciutelli, M.; Nguelefack T.B.; Quassinti L.; Bramucci, M.; Lupidi, G.; Barboni, L.; Tapondjou, A.L : Novel 3-oxo and 3,24-dinor-2,4- seco-oleanane- type triterpenes from Terminalia ivorensis A. Chev . In: Chemistry and Biodiversitry, 2011, 1301-1309
2010 Teke, G. N., Kuiaté, J. R., Kueté, V., Teponno, R. B., Tapondjou, A. L., Vilerem, Antidarrheal activity of extracts and compounds from Trilepisium madagascariense stem bark, . In: Indian Journal of Pharmacology , 2010, 157-163
2010 -Nguelefack, T. B, Dutra, R. C., Paszcuk,A. F., Andrade, E. L., Tapondjou, A. L., Calixto, J., B. : Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L., var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K+ channel activation, . In: Journal of Ethnopharmacology , 2010, 567-574
2010 Nzedong Tigoufack I. B., Ngnokam D., Tapondjou A.L., Harakat D., Voutquenne L.: Cycloartane glycosides from leaves of Oxyanthus pallidus. In: Phytochemistry 71, 2182-2186., 2010, 2182-2186
2010 Ponou, K. B, Teponno, R. B., Ricciutelli, M., Quassinti L., Bramucci, M., Lupidi, G., Barboni, L., Tapondjou, A.L. : Dimeric antioxidant and cytotoxic triterpenoid saponins from Terminalia ivorensis A. Chev. . In: Phytochemistry , 2010, 2108-2115
2010 Nzowa, K.L, Barboni, L., Teponno, R. B., Ricciutelli, M., Lupidi, G., Quassinti L., Bramucci M., Tapondjou, A.L. : Rheediinosides A and B, two antiproliferative and antioxidant triterpene saponins from Entada rheedii . In: Phytochemistry , 2010, 254-261
2009 Tankeu Nyaa L. B., Tapondjou A. L., Barboni L., Tamokou J. D., Kuiaté J. R., Tane P. Park H. J. : NMR Assignment and Antimicrobial/Antioxidant Activities of 1β-Hydroxyeuscaphic acid from the Seeds of Butyrospermum parkii . In: Natural Product Science, 2009, 76-82
2008 Teponno, R. B., Tapondjou, A.L., Abou-Mansour, E., Stoekli-Evans, H., Tane, P., Barboni, L: Bafoudiosbulbins F and G, further clerodane diterpenoids from Dioscorea bulbifera L. var sativa and revised structure of Bafoudiosbulbin B . In: Phytochemistry , 2008, 2374-2379
2008 Tapondjou, A.L., Ponou, K. B.,Teponno, R.B., Mbiantcha, M., Djoukeng, J.D., Nguelefack, T., B., Watcho, P., Gomez-Cadenas, A. and Park, H.J : In Vivo Anti-Inflammatory Effect of a New Steroidal Saponin, Mannioside A, and Its Derivatives Isolated from Dracaena mannii, . In: Archives of Pharmacal Research , 2008, 653-658
2008 Ponou, K. B., Barboni, L., Teponno, R.B., Mbiantcha, M., Nguelefack, T., B., Park, H.J., Lee Kyung T., Tapondjou, A.L., : Polyhydroxyoleanane –type triterpenoids from Combretum molle and their anti-inflammatory activity. . In: Phytochemistry Letters , 2008, 183-187
2007 Nam, J.H., Jung, H.J., Tapondjou, A.L., Lee, K.T., Choi, J., Kim, W.B. and Park,H.J. The anti-hyperlipidemic effects and constituents of the 19α-hydroxyursane-type triterpenoid fraction obtained from the leaves of Rubus crataegifolius. . In: Natural Product Sciences , 2007, 152-159
2007 Djoukeng, J.D., Abou-Mansour, E., Tapondjou, A.L., Lontsi, D and Tabacchi, R.: Identification of Ellagic acid derivatives from stem bark of Syzygium guineense (Myrtaceae). . In: Natural Product Communications, 2007, 261-266
2007 Teponno, R. B., Tapondjou, A.L., Jung, H.J., Nam, J.H., Tane, P. and Park, H. J. Three new clerodane diterpenoids from the bubils of Dioscorea bulbifera var. sativa. In: Helvetica Chimica Acta , 2007, 1599-1605
2006 Nguelefack, T.B, Nana, P., Atsamo, A. D., Dimo, T., Watcho, P., Dongmo, A. B., Tapondjou, A. L., Njamen D., Wansi S.L.and Kamanyi A.( : Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae). . In: Journal of Ethnopharmacology , 2006, 70-75
2006 Teponno, R. B., Tapondjou, A.L., Gatsing, D., Djoukeng, J.D., Abou-Mansour, E.,Tabacchi, R., Tane, P., Stoekli-Evans, H., Lontsi D. and Park, H. J. : Bafoudiosbulbins A and B, two antisalmonellal clerodane diterpenoids from Dioscorea bulbifera var. sativa. . In: Phytochemistry , 2006, 1957-1963
2006 Tapondjou A. L., Miyamoto T. and Lacaille-Dubois M. A: Glucuronide triterpene saponins from Bersama engleriana. . In: Phytochemistry , 2006, 2126-2132
2006 Teponno, R. B., Tapondjou, A.L., Djoukeng, J.D., Abou-Mansour, E., Tabacchi, R., Tane, P., Lontsi, D. and Park, H. J. : Isolation and NMR assignment of a Pennogenin glycoside from Dioscorea bulbifera var sativa. . In: Natural Product Sciences, 2006, 62-66
2006 Tapondjou, A. L., Mitaine-Offer, A.C., Miyamoto, T., Lerche, H., Mirjolet, J.F., Nicolas Guilbaud, N. and Lacaille-Dubois, M.A : Triterpene saponins from Schefflera abyssinica. . In: Biochemical Systematics and Ecology , 2006, 887-889
2005 Tapondjou, A.L., Makmoor, T., Lontsi, D., Sondengam, B.L.,Choudhary, M.I.and Atta-ur- Rahman. : A new antioxidant caffeoyl derivative from Cussonia bancoensis. . In: Cameroon Journal of Experimental Biology , 2005, 57-61
2005 Djoukeng, J. D., Abou-Mansour, E., Tabacchi, R., Tapondjou, A. L., Bouda, H. and Lontsi, D.: Antibacterial triterpenes from Syzygium guineense (Myrtaceae). In: Journal of Ethnopharmacology , 2005, 283-286
2005 Ngounou F.N., Manfouo R.N., Tapondjou A.L., Lontsi D., Kuete V., Penlap V., Etoa F.X., Lacaille Dubois M.A.and Sondengam B.L. : Antimicrobial Diterpenoid alkaloids from Erythropleum suaveolens (Guill & Perr.) Brenan. . In: Bulletin of the Chemical Society of Ethiopia 19, 221-226. , 2005, 221-226
2005 Tapondjou, A. L, Miyamoto, T., Mirjolet J.F, Guilbaud, N. Lacaille-Dubois, M. A.: Pursaethosides A-E, Triterpenes Saponins from Entada pursaetha. In: Journal of Natural Products , 2005, 1185-1190
2005Tapondjou, A.L., Mitaine-Offer, A.C., Sautour, M., Miyamoto, T. and Lacaille Dubois, M.A. Sphingolipids and other constituents from Cordia platythyrsa. Biochemical Systematics and Ecology . In: Biochemical Systematics and Ecology , 2005, 1293-1297
2004 Mitaine-Offer, A.C., Tapondjou, A.L., Lontsi, D., Sondengam, B.L., Choudhary, M.I., Atta- ur-Rahman and Lacaille-Dubois, M. A : Constituents isolated from Polyscias fulva.. In: Biochemical Systematics and Ecology , 2004, 607-610
2004 Shin, K. M., Kim, R.K. Tapondjou, A.L., Lontsi D., Sondengam B. L., Choudhary, M.I., Park, H. J., Choi, J., Lee, K. T. : In vitro Antiinflammatory Activity of 23-Hydroxyursolic Acid Isolated from Cussonia bancoensis in Murine Macrophage Raw 264.7 Cells . In: Planta Medica , 2004, 803-807
2003 Mitaine-Offer, A.. C., Djoukeng, J. D., Tapondjou, A.L, Bouda, H., Lerche, H., Lontsi, D. and Lacaille-Dubois, M. A. : Constituents of the leaves of Eucalyptus Saligna.. In: Biochemical Systematics and Ecology, 2003, 1457-1460
2003 Mitaine-Offer, A.G., Tapondjou, A. L, Djoukeng, J. D., Bouda, H. and Dubois Lacaille, M.A. Derivatives of Scopoletin and -sitosterol from Hymenodictyon floribundum. In: Biochemical Systematics and Ecology , 2003, 227-228
2003 Tapondjou, A.L, Lontsi, D., Sondengam, B.L., Choi, J., Lee, K.T., Jung, H. J. and Park, H. J. In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid from Cussonia bancoensis . In: Archives of Pharmacal Research , 2003, 143-146
2003 Tapondjou, A.L., Lontsi, D., Sondengam, B. L., Fazarna S., Choudhary, M.I., Atta-ur-Rahman, Heerden, F.R., Park, H.,J., and Lee, K. L : Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production . In: Journal of Natural Products , 2003, 1266-1269
2002 Fatima, N., Tapondjou, A.L., Lontsi, D., Sondengam, B.L.,Atta-ur-Rahman and Choudhary, M.I. : Quinovic acid glycosides from Mitragyna stipulosa-First examples of natural inhibitors of snake venom phosphodiesterase I. . In: Natural Product Letters, 2002, 389-393
2002 Tapondjou, A.L., Lontsi,D., Sondengam, B.L., Choudhary, M.I., Park, H.J., Choi, J. and Lee, K.T.: Structure-activity relationship of triterpenoids isolated from Mitragyna stipulosa on cytotoxicity. . In: Archives of Pharmacal Research , 2002, 270-274
2002 Tapondjou, A.L., David Lontsi, D., Bouda, H., Sondengam, B. L., Atta-ur-Rahman, Choudhary, M. I. and Heerden, F. R. : Zemoside A, A new ursane type saponin from Cussonia bancoensis . In: ACGC Chemical Research Communications , 2002, 11-19
1998 Tapondjou A. L., Ngounou F.N., Lontsi D., Sondengam B. L. and Connolly J. D: Reactions of 2, 3, 19-trihydroxyurs-12-en-triterpenoids: Pinacol Rearrangement of methyl 2, 3, 19-trihydroxy-12-en-28-oate. . In: Tetrahedron. , 1998, 2099-2106
1998 Lontsi, D., Ngounou, F.N.,Tapondjou, A.L., Sondengam,B.L., Bodo, B. and Martin, M.T: An E-ring -lactone pentacyclic triterpenes from Myrianthus serratus.. In: Phytochemistry , 1998, 2473-2476
1995 Tapondjou, A.L, Ngounou, N. F., Lontsi, D., Sondengam, B.L., Martin, M.T. and Bodo, B: Pentacyclic triterpenes from Myrianthus liberecus. . In: Phytochemistry , 1995, 1761-1764