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Prof. Dr. Tanja Gaich

Profile

Academic positionFull Professor
Research fieldsOrganic Molecular Chemistry,Natural Product Chemistry,Bioorganic and Biological Chemistry
KeywordsNatural products, Total synthesis, biomimetic synthesis (alkaloids), synthetic methodology

Current contact address

CountryGermany
CityKonstanz
InstitutionUniversität Konstanz
InstituteArbeitsgruppe Organische Chemie / Zelluläre Chemie

Host during sponsorship

Prof. Dr. Markus KalesseInstitut für Organische Chemie, Gottfried Wilhelm Leibniz Universität Hannover, Hannover
Prof. Dr. Rainer WinterFachbereich Chemie, Universität Konstanz, Konstanz
Start of initial sponsorship01/08/2012

Programme(s)

2012Sofja Kovalevskaja Award Programme

Nominator's project description

Since ancient times the isolation of substances from microorganisms and plants plays an important role in the discovery of new drugs and pharmaceuticals. To meet the requirements of medicinal applications these natural products very often have to be modified and optimized with regard to their molecular architecture. Usually, this goal is achieved through an individual synthetic access for each compound. Mrs Gaich has developed a concept which enables synthetic access to a variety of structurally and biologically different natural products through a single synthetic route. Thereby Mrs Gaich takes advantage of biosynthetic pathways, some of them hypothetic, and re-enacts (mimics) these pathways in vitro. With this fascinating process not only an efficient synthetic access to biologically important compounds is gained, but also fundamental questions regarding the biosynthesis of these complex molecular architectures are answered. Investigation of biosynthetic transformations is an efficient tool to broaden the spectrum of modern synthetic methodology.

Publications (partial selection)

2017B. Schröder; T. Gaich, Methoxatin as a target in total synthesis, . In: Synthesis 2017, 49 (8), 1746–1756., 2017, 1746-1756
2017R. Eckermann; M. Breunig, T. Gaich, Total Synthesis of strictamine via [2,3]-sigmatropic Stevens rearrangements, . In: Chem. Eur. J. 2017, (23), 16, 3938-3949. , 2017, 3938-3949
2017C. Leitner, T. Gaich, : Total synthesis of (±)-20S-Hydroxy-1,2-dehydro-pseudoaspidospermidine via a C-H activation/transannular cyclization strategy.” . In: Chem. Commun. , 2017, 7451-7453
2016E. Stempel, T. Gaich, Cyclohepta[b]indoles: A Privileged Structure Motif in Natural Products and Drug Design, . In: Acc. Chem. Res. 2016, 49 (11), 2390-2402. , 2016, 2390-2402
2016R. Eckermann, M. Breunig, T. Gaich, Formal Total Synthesis of (±)-Strictamine — The [2,3]-Stevens Rearrangement for Construction of Octahydro-2H-2,8-Methanoquinolizines . In: Chem. Commun. 2016, 52 (76), 11363-11365., 2016, 11363-11365
2016M. Pfaffenbach, A. Roller, T. Gaich, Synthesis of Indolophanes via Photochemical Macrocyclization . In: Chem. Eur. J. 2016, 22 (25), 8444-8447., 2016, 8444-8447
2016R. Eckermann, T. Gaich, The double bond configuration of Corynanthean Alkaloids, and its impact on monoterpenoid indole alkaloid biosynthesis . In: Chem. Eur. J. , 2016, 5749-5755
2016S. Krüger, T. Gaich, Total Syntheses of Vellosimine, N-Methylvellosimine, and 10-Methoxyvellosimine and Formal Synthesis of 16-Epinormacusine B through a [5+2] Cycloaddition . In: Eur. J. Org. Chem. , 2016, 4893-4899
2015Pfaffenbach, M.; Gaich, T. A Flexible Route to Indole Scaffolds – Formal Synthesis of (±)-Mersicarpine, . In: Eur. J. Org. Chem., 2015, 3427-3429
2015Pfaffenbach, M.; Gaich, T. A Photoinduced Cyclization Cascade—Total Synthesis of (?)-Leuconoxine, . In: Chem. Eur. J. , 2015, 6355-6357
2015Krüger, S.; Gaich, T. Enantioselective, Protecting-Group-Free Total Synthesis of Sarpagine Alkaloids—A Generalized Approach, . In: Angew. Chem. Int. Ed. , 2015, 315-317
2015Pfaffenbach, M.; Gaich, T.,: The Diaza[5.5.6.6]fenestrane Skeleton-Synthesis of Leuconoxine Alkaloids, . In: Chem. Eur. J. , 2015, 1-12
2014Krüger, S.; Gaich, T. Recent applications of the divinylcyclopropane–cycloheptadiene rearrangement in organic synthesis, . In: Beilstein J. Org. Chem. , 2014, 163-193
2014Gritsch, P.; Leitner, C.; Pfaffenbach, M.; Gaich, T. The Witkop Cyclization: A Photoinduced C—H Activation of the Indole System, .. In: Angew. Chem. Int. Ed. , 2014, 1208-1217
2013Gritsch, P.; Stempel, E.; Gaich, T. Enantioselective Synthesis of Cyclohepta[b]indoles: Gram-Scale Synthesis of (S)-SIRT1-Inhibitor IV, . In: Org. Lett. 2013, 15, 5472–5475., 2013, 5472-5475
2013Eckermann, R.; Gaich, T. The Akuammiline Alkaloids: Origin and Synthesis, . In: Synthesis , 2013, 2813-2823