Dr. Jan Vincent Arafiles

Profile

Academic positionLecturer, Assistant Professor, Researcher
Research fieldsBioorganic and Biological Chemistry,Biochemistry
KeywordsQuantitative microscopy, Bioconjugation, Intracellular delivery, Chemical biology, Biomolecular condensates
Honours and awards

2022: Alexander von Humboldt Fellowship for Postdocs

2015: Japanese Government (Monbukagakusho) Scholarship

Current contact address

CountryJapan
CityUji City
InstitutionKyoto University
InstituteInstitute of Advanced Energy

Host during sponsorship

Prof. Dr. Christian HackenbergerAbteilung Chemische Biologie, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin
Start of initial sponsorship01/10/2022

Programme(s)

2022Humboldt Research Fellowship Programme for Postdocs

Publications (partial selection)

2023 Jan Vincent V. Arafiles, Jonathan Franke, Luise Franz, Jacobo Gómez-González, Kristin Kemnitz-Hassanin, and Christian P. R. Hackenberger: Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins. In: Journal of the Americal Chemical Society, 145, 2023, 24535–24548
2020Sakamoto, Kentarou and Furukawa, Hiroto and Arafiles, Jan Vincent and Imanishi, Miki and Matsuura, Kazunori and Futaki, Shiroh: Artificial Nanocage Formed via Self-Assembly of beta-Annulus Peptide for Delivering Biofunctional Proteins into Cell Interiors. In: Bioconjugate Chemistry, 33, 2020, 311 -- 320
2020Hsu, Wei-Yuan, Masuda Toshihiro, Afonin Sergii, Sakai Takayuki, Arafiles Jan Vincent V., Kawano Kenichi, Hirose Hisaaki, Imanishi Miki, Ulrich Anne S. and Futaki Shiroh: Enhancing the activity of membrane remodeling epsin-peptide by trimerization. In: Bioorganic & Medicinal Chemistry Letters, 30, 2020, 127190
2020Futaki, Shiroh and Arafiles, Jan Vincent V. and Hirose, Hisaaki: Peptide-assisted Intracellular Delivery of Biomacromolecules. In: Chemistry Letters, 49, 2020, 1088--1094
2020Arafiles, Jan Vincent V. and Hirose, Hisaaki and Akishiba, Misao and Tsuji, Shogo and Imanishi, Miki and Futaki, Shiroh: Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane-Lytic Peptides to Facilitate Endosomal Escape. In: Bioconjugate Chemistry, 31, 2020, 547-553
n.n.Nagano, Yuki and Arafiles, Jan Vincent and Kuwata, Keiko and Kawaguchi, Yoshimasa and Imanishi, Miki and Hirose, Hisaaki and Futaki, Shiroh: {Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein–Protein Interactions on a Cell-Penetrating Peptide Scaffold}. In: Molecular Pharmaceutics, 0, n.n., null -- null
n.n.Nakagawa, Yuna and Arafiles, Jan Vincent and Kawaguchi, Yoshimasa and Nakase, Ikuhiko and Hirose, Hisaaki and Futaki, Shiroh: {Stearylated Macropinocytosis-Inducing Peptides Facilitating the Cellular Uptake of Small Extracellular Vesicles}. In: Bioconjugate Chemistry, 0, n.n., null -- null