Dr. Manuel Flores Leon

Profile

Academic positionPost Doc
Research fieldsMolecular Biology and Physiology of Nerve and Glia Cells,Biochemistry
KeywordsNeurodegeneration, Parkinson's Disease, synuclein, Lipid metabolism

Current contact address

CountryGermany
CityGöttingen
InstitutionGeorg-August-Universität Göttingen
InstituteAbteilung Experimentelle Neurodegeneration

Host during sponsorship

Prof. Dr. Tiago Fleming OuteiroAbteilung Experimentelle Neurodegeneration, Georg-August-Universität Göttingen, Göttingen
Start of initial sponsorship01/01/2025

Programme(s)

2024Humboldt Research Fellowship Programme for Postdocs

Publications (partial selection)

2024Avilés-Rosas, Vh and Rendón-Ochoa, Ea and Hernández-Flores, T and Flores-León, M and Arias, C and Galarraga, E and Bargas, J: {Role of M4 -receptor cholinergic signaling in direct pathway striatal projection neurons during dopamine depletion}. In: Synapse (New York, N.Y.), 78, 2024, e22287
2023Flores-León, Manuel and Outeiro, Tiago Fleming: {More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy}. In: Acta neuropathologica, 146, 2023, 369--385
2022Vasili, Eftychia; Dominguez-Meijide, Antonio; Flores-León, Manuel; Al-Azzani, Mohammed; Kanellidi, Angeliki; Melki, Ronald; Stefanis, Leonidas; Outeiro, Tiago Fleming: {Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells}. In: Molecular neurobiology, 59, 2022, 1273--1284
2022Torres-Arciga, Karla; Flores-León, Manuel; Ruiz-Pérez, Samuel; Trujillo-Pineda, Magalli; González-Barrios, Rodrigo; Herrera, Luis A.: {Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape}. In: Frontiers in genetics, 13, 2022,
2021Flores-León, Manuel; Alcaraz, Nicolás; Pérez-Domínguez, Martha; Torres-Arciga, Karla; Rebollar-Vega, Rosa; {De la Rosa-Velázquez}, Inti A; Arriaga-Canon, Cristian; Herrera, L. A; Arias, Clorinda; González-Barrios, Rodrigo: {Transcriptional Profiles Reveal Deregulation of Lipid Metabolism and Inflammatory Pathways in Neurons Exposed to Palmitic Acid}. In: Molecular neurobiology, 58, 2021, 4639--4651
2019Flores-León, Manuel; Pérez-Domínguez, Martha; González-Barrios, Rodrigo, Arias, Clorinda: {Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons}. In: Neurochemical Research, 44, 2019, 1745--1754
2018Sánchez-Alegría, Karina; Flores-León, Manuel; Avila-Muñoz, Evangelina; Rodríguez-Corona, Nelly; Arias, Clorinda: {PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions}. In: International journal of molecular sciences, 19, 2018,