Dr. Manuel Flores Leon

Profil

Derzeitige StellungPost Doc
FachgebietMolekulare Biologie und Physiologie von Nerven- und Gliazellen,Biochemie
KeywordsNeurodegeneration, Parkinson's Disease, synuclein, Lipid metabolism

Aktuelle Kontaktadresse

LandDeutschland
OrtGöttingen
Universität/InstitutionGeorg-August-Universität Göttingen
Institut/AbteilungKlinik für Neurologie

Gastgeber*innen während der Förderung

Prof. Dr. Tiago Fleming OuteiroAbteilung Experimentelle Neurodegeneration, Georg-August-Universität Göttingen, Göttingen
Beginn der ersten Förderung01.01.2025

Programm(e)

2024Humboldt-Forschungsstipendien-Programm für Postdocs

Publikationen (Auswahl)

2026Flores-León M, Outeiro TF.: Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids. In: Movement Disorders, 2026,
2025Flores-León M, Outeiro TF.: Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy. In: FEBS Journal, 2025,
2025Rueda-Díaz SS, Soto-Santarriaga IF, Torres-Arciga K, García-Cruz VM, González-Barrios R, Flores-León M, Arias C.: Palmitic Acid Induces Dynamic Time-Dependent Alterations in HDACs, Neuronal Chromatin Acetylation, and Gene Expression. In: Neurochemical Research, 2025,
2024Avilés-Rosas, Vh and Rendón-Ochoa, Ea and Hernández-Flores, T and Flores-León, M and Arias, C and Galarraga, E and Bargas, J: Role of M4 -receptor cholinergic signaling in direct pathway striatal projection neurons during dopamine depletion. In: Synapse (New York, N.Y.), 78, 2024, e22287
2023Flores-León, Manuel and Outeiro, Tiago Fleming: More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy. In: Acta neuropathologica, 146, 2023, 369--385
2022Vasili, Eftychia; Dominguez-Meijide, Antonio; Flores-León, Manuel; Al-Azzani, Mohammed; Kanellidi, Angeliki; Melki, Ronald; Stefanis, Leonidas; Outeiro, Tiago Fleming: Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells. In: Molecular neurobiology, 59, 2022, 1273--1284
2022Torres-Arciga, Karla; Flores-León, Manuel; Ruiz-Pérez, Samuel; Trujillo-Pineda, Magalli; González-Barrios, Rodrigo; Herrera, Luis A.: Histones and their chaperones: Adaptive remodelers of an ever-changing chromatinic landscape. In: Frontiers in genetics, 13, 2022,
2021Flores-León M, Lázaro DF, Shvachiy L, Krisko A, Outeiro TF.: In silico analysis of the aggregation propensity of the SARS-CoV-2 proteome: Insight into possible cellular pathologies. In: Biochim Biophys Acta Proteins Proteom, 2021,
2021Flores-León, Manuel; Alcaraz, Nicolás; Pérez-Domínguez, Martha; Torres-Arciga, Karla; Rebollar-Vega, Rosa; {De la Rosa-Velázquez}, Inti A; Arriaga-Canon, Cristian; Herrera, L. A; Arias, Clorinda; González-Barrios, Rodrigo: Transcriptional Profiles Reveal Deregulation of Lipid Metabolism and Inflammatory Pathways in Neurons Exposed to Palmitic Acid. In: Molecular neurobiology, 58, 2021, 4639--4651
2019Flores-León, Manuel; Pérez-Domínguez, Martha; González-Barrios, Rodrigo, Arias, Clorinda: Palmitic Acid-Induced NAD+ Depletion is Associated with the Reduced Function of SIRT1 and Increased Expression of BACE1 in Hippocampal Neurons. In: Neurochemical Research, 44, 2019, 1745--1754
2018Sánchez-Alegría, Karina; Flores-León, Manuel; Avila-Muñoz, Evangelina; Rodríguez-Corona, Nelly; Arias, Clorinda: PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. In: International journal of molecular sciences, 19, 2018,