Prof. Dr. Franz Hofmann

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietPharmakologie,Anatomie und Physiologie,Molekulare und zelluläre Neurologie und Neuropathologie
KeywordscGMP kinase, L-type calcium channel

Aktuelle Kontaktadresse

LandDeutschland
OrtMünchen
Universität/InstitutionTechnische Universität München
Institut/AbteilungInstitut für Pharmakologie und Toxikologie

Gastgeber*innen während der Förderung

Beginn der ersten Förderung01.01.2003

Programm(e)

2002Max Planck-Forschungspreis-Programm

Publikationen (Auswahl)

2008Lacinova L, Moosmang S, Langwieser N, Hofmann F, Kleppisch T Cav1.2 Calcium Channels modulate the spiking pattern of hippocampal pyramidal cells.. In: Life Sciences, 2008, 41-49
2008Lemke T, Welling A, Christel CJ, Blaich A, Bernhard D, Lenhardt P, Hofmann F, Moosmang S: Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Cav1.2 phosphorylation site S1928A mutant mice. . In: J Biol Chem., 2008, 34738-34744
2007Döring B, Pfitzer G, Adam B, Liebregts T, Eckardt D, Holtmann G, Hofmann F, Feil S, Feil R, Willecke K Ablation of connexin43 in smooth muscle cells of the mouse intestine: functional insights into physiology and morphology. . In: Cell Tissue Res., 2007, 333-342
2007Antl M, v. Brühl M-L, Eiglsperger C, Werner M, Konrad I, Köcher T, Wilm M, Hofmann F, Massberg S, Schlossmann J: IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. In: Blood, 2007, 552-559
2007Essin K, Welling A, Hofmann F, Luft FC, Gollasch M, Moosmang S: Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells. In: J Physiol., 2007, 205-219
2007Wörner R, Lukowski R, Hofmann F, Wegener JW: cGMP signals mainly through cAMP Kinase in permeabilized murine aorta. In: Am J Physiol Heart Circ Physiol., 2007, 237-244
2006Paula M. Bryan, Dmitri Smirnov, Albert Smolenski, Susanne Feil, Robert Feil, Franz Hofmann, Suzanne Lohmann, Lincoln R. Potter: A Sensitive Method for Determining the Phosphorylation Status of Natriuretic Peptide Receptors: cGK-I alpha Does Not Regulate NPR-A. In: Biochemistry, 2006, 1295-1303
2006Tae-Seong Lee, Rosi Karl, Sven Moosmang, Peter Lenhardt, Norbert Klugbauer, Franz Hofmann, Thomas Kleppisch, Andrea Welling: Calmodulin Kinase II Is Involved in Voltage-dependent Facilitation of the L-type Cav1.2 Calcium Channel. In: J. of Biological Chemistry, 2006, 25560-25567
2006Jörg W. Wegener, Verena Schulla, Angela Koller, Norbert Klugbauer, Robert Feil, Franz Hofmann: Control of intestinal motility by the Cav1.2 L-type calcium channel in mice. In: The FASEB Journal, 2006, 1260
2006Bruno Gomes, Magali Savignac, Marilena Djata Cabral, Pierre Paulet, Marc Moreau, Catharine Leclerc, Robert Feil, Franz Hofmann, Jean-Charles Guery, Gilles Dietrich, Lucette Pelletier: The cGMP/Protein G Pathway Contributes to Dihydropyridine-sensitive Calcium Response and Cytokine Production in TH2 Lymphocytes. In: J. of Biological Chemistry, 2006, 12421-12427
2006Fiedler B, Feil R, Hofmann F, Willenbockel C, Drexler H, Smolenski A, Lohmann SM, Wollert KC. cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase-apoptosis signaling in cardiac myocytes.. In: J Biol Chem , 2006, 32831-32840
2005Claudia G. Werner, Virginia Godfrey, Roland R. Arnold, Gerald L. Featherstone, Diane Bender, Jens Schlossmann, Matthias Schiemann, Franz Hofmann, Katherine B. Pryzwansky: Neutrophil Dysfunction in Guanosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase I-Deficient Mice1. In: The Journal of Immunology, 2005, 1919-1929
2005Sven Moosmang, Nicole haider, Norbert Klugbauer, Helmuth Adelsberger, Nicolas Langwieser, Jochen Müller, Michael Stiess, Else Marais, Verena Schulla, Lubica Lacinova, Sandra Goebbels, Klaus-Armin Nave, Daniel R. Storm, Franz Hofmann, Thomas Kleppisch: Role of Hippocampal Cav1.2 Ca2+ Channels in NMDA Receptor-Independent Synaptic Plasticity and Spatial Memory. In: The Journal of Neuroscience, 2005, 9883-9892
2005Stefan Herrmann, Juliane Stieber, Andreas Ludwig, Franz Hofmann: Schrittmacherkanäle: Wächter an Hirn und Herz. In: Volker ter Meulen, Leopoldina-Jahrbuch 2004. Deutsche Akademie der Naturforscher Leopoldina, 2005. 421-428
2004Jorg W. Wegener, Verena Schulla, Tae-Seong Lee, Angela Koller, Susanne Feil, Robert Feil, thomas Kleppisch, Norbert Klugbauer, Sven Moosmang, Andrea Welling, Franz Hofmann: An essential role of Cav1.2 L-type calcium channel for urinary bladder function. In: THE FASEB Journal, 2004, 1-18
2004Stuart J. Marshall, Yotis A. Senis, Jocelyn M. Auger, Robert Feil, Franz Hofmann, Gary Salmon, J. Thomas Peterson, Frank burslem, Steve P. Watson: GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase. In: BLOOD, 2004, 2601-2609
2004Irmgard Tegeder, Domenico Del Turco, Achim Schmidtko, Matthias Sausbier, Robert Feil, Franz Hofmann, Thomas Deller, Peter Ruth, Gerd Geisslinger: Reuced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. In: PNAS, 2004, 3253-3257
2003Zhenyu Li, Xiaodong Xi, Minxi Gu, Robert Feil, Richard D. Ye, Martin Eigenthaler, Franz Hofmann, Xiaoping Du: A Stimulatory Role for cGMP-Dependent Protein Kinase in Platelet Activation. In: Cell, 2003, 77-86
2003Arie B. Vaandrager, Boris M. Hogema, Marcel Edixhoven, Carolie M. M. van den Burg, Alice G. M. Bot, Peter Klatt, Peter Ruth, Franz Hofmann, Jozef Van Damme, Joel Vandekerckhove, Hugo R. de Jonge: Autophosphorylation of CGMP-dependent Protein Kinase Type II. In: J. of Biological Chemistry, 2003, 28651-28658
2003Sven Moosmang, Verena Schulla, Andrea Welling, Robert Feil, Susanne Feil, Jörg W. Wegener, Franz Hofmann, Norbert Klugbauer: Dominant role of smooth muscle L-type calcium channell Cav1.2 for blood pressure regulation. In: The EMBO Journal, 2003, 6027-6034
2003Verena Schulla, Erik Renström, Robert Feil, Susanne Feil, Isobel Franklin, Asllan Gjinovci, Xing-Jun Jing, Dirk Laux, Ingmar Lundquist, Mark A. Magnuson, Stefanie Obermüller, Charlotta S. Olofsson, Albert Salehi, Anna Wendt, Norbert Klugbauer, Claes B. Wollheim, Patrik Rorsman, Franz Hofmann: Impaired insulin secretion and glucose tolerance in beta cell-selective CaV1.2Ca2+ channel null mice. In: The EMBO Journal, 2003, 3844-3854
2003Masami Shimizu-Albergine, Sergei D. Rybalkin, Irina G. Rylbalkina, Robert Feil, Wiebke Wolfsgruber, Franz Hofmann, Joseph A. Beavo: Individual Cerebellar Purkinje Cells Express Different cGMP Phosphodiesterases (PDEs): In Vivo Phosphorylation of cGMP-Specific PDE (PDE5) as an Indicator of cGMP-dependent protein kinase (PKG) Activation. In: The J. of Neuroscience , 2003, 6452-6459
2003S. Hattar, R. J. Lucas, N. Mrosovsky, S. Thompson, R. H. Douglas, M. W. Hankins, J. Lem, M. Blei, Franz Hofmann, R. G. Foster, K.-W. Yau: Melanopsin and rod-cone photoreceptive systems account for all major acessory visual functions in mice. In: Nature, 2003, 76-81
2002Sergei D. Rybalkin, Irina G. Rybalina, Robert Feil, Franz Hofmann, Joseph A. Beavo: Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells . In: The J. of Biological Chemistry, 2002, 3310-3317