Prof. Dr. Ilza K. Pajeva

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietPharmazie,Softwaretechnik und Programmiersprachen
KeywordsABC transporters, Computer Aided Drug Design, Molecular modeling, Multidrug Resistance,MDR, Quantitative Structure-Activity Relationships,QSAR

Aktuelle Kontaktadresse

LandBulgarien
OrtSofia
Universität/InstitutionBulgarian Academy of Sciences
Institut/AbteilungInstitute of Biophysics and Biomedical
Websitewww.clbme.bas.bg

Gastgeber*innen während der Förderung

Prof. Dr. Joachim K. SeydelInstitut für Experimentelle Biologie und Medizin, Forschungszentrum Borstel – Leibniz-Lungenzentrum (FZB), Borstel
Prof. Dr. Michael WieseAbteilung Pharmazeutische Chemie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn
Beginn der ersten Förderung01.01.1993

Programm(e)

1992Humboldt-Forschungsstipendien-Programm

Publikationen (Auswahl)

2013Ilza K. Pajeva, Katja Sterz, Kerstin Steggemann, Federico Marighetti, Mathias Christlieb, Michael Wiese: Interactions of the multidrug resistance modulators tariquidar and elacridar and their analogs with P-glycoprotein. In: ChemMedChem, 2013, 1701-1713
2013Ilza K. Pajeva, Markus Hanl, Michael Wiese: Protein contacts and ligand binding in the inward-facing model of human P-glycoprotein. In: ChemMedChem, 2013, 748-762
2013Filip Fratev, Svava Jónsdóttir, Ilza Pajeva: Structural insight into the UNC-45-Myosin complex. In: Proteins, 2013, 1212-1221
2012Tania Pencheva, David Lagorce, Ilza Pajeva, Bruno Villoutreix, Maria Miteva: AMMOS Software: Method and Application. In: Riccardo Baron, Computational Drug Discovery and Design (Methods Mol. Biol.). Springer New York, 2012. 127-141
2012Dessislava Jereva, Ilza Pajeva, Tania Pencheva: Data extraction module – a supplementary tool for AMMOS_ProtLig software package. In: Comput Math Appl, 2012, 266-271
2012Iglika Lessigiarska, Ilza Pajeva, Penka Prodanova, Maria Georgieva, Atanas Bijev: Structure-activity relationships of pyrrole hydrazones as new anti-tuberculosis agents. In: Medicinal Chemistry, 2012, 462-473
2011Ilza K. Pajeva, Michael Wiese: Application of In Silico Methods to Study ABC Transporters Involved in Multidrug Resistance. In: Maria A. Miteva, In Silico Lead Discovery . Bentham Science, 2011. 144-162
2011Ivanka Tsakovska, Ilza Pajeva, Petko Alov, Andrew Worth: Recent advances in the molecular modelling of estrogen receptor-mediated toxicity. In: Adv Protein Chem Struct Biol, 2011, 217-251
2011Anne Pick, Henrik Müller, Ralf Mayer, Britta Haenisch, Ilza K. Pajeva, Mathias Weigt, Heinz Bönisch, Christa E. Müller, Michael Wiese Structure-Activity Relationships of Flavonoids ss Inhibitors of Breast Cancer Resistance Protein (BCRP). In: Bioorg. Med. Chem., 2011, 2090-2102
2011Ilza K. Pajeva: Zeit - abhängig Präsentationen der Wechselwirkungen von Arzneistoffen. In: Dietmar Goltschnigg, Phänomen Zeit: Dimensionen und Strukturen in Kultur und Wissenschaft . Stauffenburg Verlag 2011. 307-308
2010Tania Pencheva, O.S. Sumana, Ilza K. Pajeva, Maria Miteva: Post-docking virtual screening of diverse binding pockets: Comparative study using DOCK, AMMOS, X-Score and FRED scoring functions. In: Eur J Med Chem, 2010, 2622-2628
2009Ilza K. Pajeva Christoph Globisch, Michael Wiese Combined pharmacophore modeling, docking and 3D QSAR study of ABCB1 and ABCC1 transporter inhibitors. In: ChemMedChem, 2009, 1883-1896
2009Ilza K. Pajeva, Christoph Globisch, Michael Wiese Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein. In: FEBS J, 2009, 7016-7026
2009Ilza K. Pajeva, Michael Wiese: Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators. In: The AAPS Journal, 2009, 435-444
2008Christoph Globisch Ilza K. Pajeva Michael Wiese: Identification of Putative Binding Sites of P-glycoprotein Based on its Homology Model. In: ChemMedChem, 2008, 280-295
2008Christoph Globisch Ilza Pajeva Michael Wiese: Identification of putative binding sites of P-glycoprotein based on its homoliogy model. In: ChemMedChem, 2008, 280-295
2007Michael Wiese Ilza Pajeva: Comprehensive Medicinal Chemistry II. Elsevier, 2007
2005Ilza Pajeva Christoph Globisch Romy Fleisher Ivanka Tsakovska Michael Wiese: Molecular modeling of P-glycoprotein and related drugs. In: Med. Chem. Res., 2005, 106-117
2004Ilza K. Pajeva Dimitar K. Todorov Joachim K. Seydel: Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol. In: Europ. J. Pharm. Sci, 2004, 243-250
2003Ivanka M. Tsakovska Ilza K. Pajeva Michael Wiese: Molecular modeling of phenothiazines and structurally related multidrug resistance modulators: comparative study in human and animal tumor cell lines. In: Biotechnol. Biotechn. Eq., 2003, 163-169
2002Ilza K. Pajeva, M. Wiese: Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (Hypothesis). In: J. Med. Chem., 2002, 5671-5686