Prof. Dr. Nikolaus Pfanner

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietBiochemie

Aktuelle Kontaktadresse

LandDeutschland
OrtFreiburg
Universität/InstitutionAlbert-Ludwigs-Universität Freiburg
Institut/AbteilungInstitut für Biochemie und Molekularbiologie

Gastgeber*innen während der Förderung

Beginn der ersten Förderung01.01.2003

Programm(e)

2002Max Planck-Forschungspreis-Programm

Publikationen (Auswahl)

2006van der Laan, M., Wiedemann, N., Mick, D.U., Guiard, B., Rehling, P., and Pfanner, N.: A Role for Tim21 in Membrane-Potential-Dependent Preprotein Sorting in Mitochondria.. In: Curr.Biol., 2006, 2271-2276
2006Wiedemann, N., Urzica, E., Guiard, B., Müller, H., Lohaus, C., Meyer, H.E., Ryan, M.T., Meisinger, C., Mühlenhoff, U., Lill, R., and Pfanner, N. Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins.. In: EMBO J., 2006, 184-195
2006Zahedi, R.P., Sickmann, A., Boehm, A.M., Winkler, C., Zufall, N., Schönfisch, B., Guiard, B., Pfanner, N. and Meisinger, C.: Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.. In: Mol. Biol. Cell, 2006, 1436-1450
2006Meinecke, M., Wagner, R., Kovermann, P., Guiard, B., Mick, D.U., Hutu, D.P., Voos, W., Truscott, K.N., Chacinska, A., Pfanner, N. and Rehling, P. Tim50 Maintains the Permeability Barrier of the Mitochondrial Inner Membrane.. In: Science, 2006, 1523-1526
2005Sanjuán Szklarz, L.K., Guiard, B., Rissler, M., Wiedemann, N., Kozjak, V., van der Laan, M., Lohaus, C., Marcus, K., Meyer, H.E., Chacinska, A., Pfanner, N., and Meisinger, C. (: Inactivation of the mitochondrial heat shock protein Zim17 leads to aggregation of matrix Hsp70s followed by pleiotropic effects on morphology and protein biogenesis. . In: J. Mol. Biol., 2005, 206-218
2005Chacinska, A., Lind, M., Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling, P. Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. . In: Cell, 2005, 817-829
2005van der Laan, M., Chacinska, A., Lind, M., Perschil, I., Sickmann, A., Meyer, H.E., Guiard, B., Meisinger, C., Pfanner, N., and Rehling, P. Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor.. In: Mol. Cell. Biol., 2005, 7449-7458
2005Rissler, M., Wiedemann, N., Pfannschmidt, S., Gabriel, K., Guiard, B., Pfanner, N., and Chacinska, A.: The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins. . In: J. Mol. Biol., 2005, 485-492
2004Wiedemann, N., Truscott, K.N., Pfannschmidt, S., Guiard, B., Meisinger, C., and Pfanner, N.: Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway. . In: J. Biol. Chem., 2004, 18188-18194
2004Chacinska, A., Pfannschmidt, S., Wiedemann, N., Kozjak, V., Sanjuán Szklarz, L.K., Schulze-Specking, A., Truscott, K.N., Guiard, B., Meisinger, C., and Pfanner, N.: Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins.. In: EMBO J., 2004, 3735-3746
2004Frazier, A.E., Dudek, J., Guiard, B., Voos, W., Li, Y., Lind, M., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Bilanchone, V., Cumsky, M.G., Truscott, K.N., Pfanner, N., and Rehling, P. Pam16 has an essential role in the mitochondrial protein import motor. . In: Nature Struct. Mol. Biol. , 2004, 226-233
2004Milenkovic, D., Kozjak, V., Wiedemann, N., Lohaus, C., Meyer, H.E., Guiard, B., Pfanner, N., and Meisinger, C. Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability.. In: J. Biol. Chem., 2004, 22781-22785
2004Meisinger C., Rissler M., Chacinska A., Szklarz L.K., Milenkovic D., Kozjak V., Schönfisch B., Lohaus C., Meyer H.E., Yaffe M.P., Guiard B., Wiedemann N., and Pfanner N. The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane.. In: Dev. Cell , 2004, 61-71
2004Li Y., Dudek J., Guiard B., Pfanner N., Rehling P., and Voos W. The presequence translocase-associated protein import motor of mitochondria: Pam16 functions in an antagonistic manner to Pam18.. In: J. Biol. Chem., 2004, 38047-38054
2003Truscott KN, Voos W, Frazier AE, Lind M, Li Y, Geissler A, Dudek J, Müller H, Sickmann A, Meyer HE, Meisinger C, Guiard B, Rehling P, and Pfanner N. A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria.. 2003, 707-713
2003Kozjak, V., Wiedemann, N., Milenkovic, D., Lohaus, C., Meyer, H.E., Guiard, B., Meisinger, C., and Pfanner, N.: An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. . In: J. Biol. Chem., 2003, 48520-48523
2003Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan MT, Pfanner N, and Meisinger C. Machinery for protein sorting and assembly in the mitochondrial outer membrane.. In: Nature, 2003, 565-571
2003Frazier A Chacinska A, Truscott K ,Guiard B, Pfanner N, Rehling P: Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space. . In: Mol. Cell. Biol., 2003, 7818-7828
2003Chacinska A, Rehling P, Guiard B, Frazier A, Schulze-Specking A, Pfanner N, Voos W, Meisinger C: Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex.. In: EMBO J., 2003, 5370-5381
2003Sickmann, A., Reinders, J., Wagner, Y., Joppich, C. Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N., and Meisinger, C.: The proteome of Saccharomyces cerevisiae mitochondria.. In: Proc. Natl. Acad. Sci. USA, 2003, 13207-13212