Prof. Dr. Stefan Szedlacsek

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietBiochemie,Zellbiologie,Strukturbiologie
Keywordsreceptor, enzyme, protein structure, protein tyrosine phosphatase, signal transduction

Aktuelle Kontaktadresse

LandRumänien
OrtBucharest
Universität/InstitutionInstitute of Biochemistry
Institut/AbteilungDepartment of Biochemistry

Gastgeber*innen während der Förderung

Prof. Dr. Bent HavsteenBiochemisches Institut, Christian-Albrechts-Universität zu Kiel, Kiel
Prof. Dr. Hartmut MichelAbteilung Molekulare Membranbiologie, Max-Planck-Institut für Biophysik, Frankfurt am Main
Prof. Dr. Roger GoodyAbteilung Physikalische Biochemie, Max-Planck-Institut für molekulare Physiologie, Dortmund
Prof. Dr. Axel J. ScheidigFachrichtung Biophysik, Universität des Saarlandes, Homburg
Beginn der ersten Förderung01.11.1992

Programm(e)

1991Humboldt-Forschungsstipendien-Programm

Publikationen (Auswahl)

2022Szedlacsek, Horea Stefan and Bajusz, D{\'a}vid and Badea, Rodica Aura and Pop, Andreea and Bic{\u a}, Constantin C{\u a}t{\u a}lin and Ravasz, Lilla and Mittli, D{\'a}niel and M{\'a}ty{\'a}s, Dominik and Necula-Petr{\u a}reanu, Georgiana and Munteanu, Cristian V A and Papp, Ildik{\'o} and Juh{\'a}sz, G{\'a}bor and Hritcu, Lucian and Keser{\H u}, György Mikl{\'o}s and Szedlacsek, Stefan Eugen: Designed peptide inhibitors of {STEP} {phosphatase-GluA2} {AMPA} receptor interaction enhance the cognitive performance in rats. In: J. Med. Chem., 65, 2022, 217--233
2022Patras, Laura and Ionescu, Aura Elena and Munteanu, Cristian and Hajdu, Renata and Kosa, Andreea and Porfire, Alina and Licarete, Emilia and Rauca, Valentin Florian and Sesarman, Alina and Luput, Lavinia and Bulzu, Paul and Chiroi, Paul and Tranca, Rares Andrei and Meszaros, Marta-Szilvia and Negrea, Giorgiana and Barbu-Tudoran, Lucian and Potara, Monica and Szedlacsek, Stefan and Banciu, Manuela: Trojan horse treatment based on {PEG-coated} extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo. In: Cancer Biol. Ther., 23, 2022, 1--16
2020Manolache, Alexandra and Selescu, Tudor and Maier, G. Larisa and Mentel, Mihaela and Ionescu, Aura Elena and Neacsu, Cristian and Babes, Alexandru and Szedlacsek, Stefan Eugen: Regulation of TRPM8 channel activity by Src-mediated tyrosine phosphorylation. In: Journal of Cellular Physiology, 235, 2020, 5192-5203
2019Ionescu, Aura E. and Mentel, Mihaela and Munteanu, Cristian V.A. and Sima, Livia E. and Martin, Eliza C. and Necula-Petrareanu, Georgiana and Szedlacsek, Stefan E.: Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation. In: International Journal of Molecular Sciences, 20, 2019,
2019Alina-Andreea Zimta and Vlad Schitcu and Eugen Gurzau and Crina Stavaru and Gina Manda and Stefan Szedlacsek and Ioana Berindan-Neagoe: Biological and molecular modifications induced by cadmium and arsenic during breast and prostate cancer development. In: Environmental Research, 178, 2019, 108700
2019Scheidig, A J and Horvath, D and Szedlacsek, S E: Crystal structure of a xylulose 5-phosphate phosphoketolase. Insights into the substrate specificity for xylulose 5-phosphate. In: J. Struct. Biol., 207, 2019, 85--102
2019Scheidig AJ, Horvath D, Szedlacsek SE.: Crystal structure of a xylulose 5-phosphate phosphoketolase. Insights into the substrate specificity for xylulose 5-phosphate.. In: J Struct Biol., 2019, 85-102
2018Rosca AM, Mitroi DN, Cismasiu V, Badea R, Necula-Petrareanu G, Preda MB, Niculite C, Tutuianu R, Szedlacsek S, Burlacu A.: Collagen regulates the ability of endothelial progenitor cells to protect hypoxic myocardium through a mechanism involving miR-377/VE-PTP axis.. In: J Cell Mol Med., 2018, 4700-4708
2018Mentel M, Ionescu AE, Puscalau-Girtu I, Helm MS, Badea RA, Rizzoli SO, Szedlacsek SE.: WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton.. In: Scientific Reports, 2018, 2910
2016Mentel M, Badea RA, Necula-Petrareanu G, Mallikarjuna ST, Ionescu AE, Szedlacsek SE.: Expression, Purification, and Kinetic Analysis of PTP Domains.. In: Methods Mol Biol., 2016, 39-66
2014Petrareanu G, Balasu MC, Vacaru AM, Munteanu CV, Ionescu AE, Matei I, Szedlacsek SE.: Phosphoketolases from Lactococcus lactis, Leuconostoc mesenteroides and Pseudomonas aeruginosa: dissimilar sequences, similar substrates but distinct enzymatic characteristics.. In: Appl Microbiol Biotechnol., 2014, 7855-7867
2013Böhmer F, Szedlacsek S, Tabernero L, Ostman A, den Hertog J.: Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.. In: FEBS J. , 2013, 413-431
2010Petrareanu G, Balasu MC, Zander U, Scheidig AJ, Szedlacsek SE.: Preliminary X-ray crystallographic analysis of the D-xylulose 5-phosphate phosphoketolase from Lactococcus lactis.. In: Acta Crystallogr Sect F Struct Biol Cryst Commun. , 2010, 805-807
2007Köhn M, Gutierrez-Rodriguez M, Jonkheijm P, Wetzel S, Wacker R, Schroeder H, Prinz H, Niemeyer CM, Breinbauer R, Szedlacsek SE, Waldmann H.: A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase.. In: Angew Chem Int Ed Engl., 2007, 7700-7703
2006Dursina B, Reents R, Delon C, Wu Y, Kulharia M, Thutewohl M, Veligodsky A, Kalinin A, Evstifeev V, Ciobanu D, Szedlacsek SE, Waldmann H, Goody RS, Alexandrov K.: Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.. In: J Am Chem Soc. , 2006, 2822-2835
2005Vlad MO, Szedlacsek SE, Pourmand N, Cavalli-Sforza LL, Oefner P, Ross J.: Fisher's theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics.. In: Proc Natl Acad Sci U S A. , 2005, 9848-9853
2004V.B. Cismasiu, S.A. Denes, H. Reilander, H. Michel, S.E. Szedlacsek: The MAM (Meprin/A5-protein/PTPmu) Domain Is a Homophilic Binding Site Promoting the Lateral Dimerization of Receptor-like Protein-tyrosine Phosphatase μ. In: J. Biol. Chem. , 2004, 26922-26931
2001S.E. Szedlacsek, A.R. Aricescu, T.A. Fulga, L. Renault, A.J. Scheidig: Crystal structure of PTP-SL/BR7 catalytic domain: Implications for MAP kinase regulation. In: J. Mol. Biol. , 2001, 557-568
2001A.R Aricescu, T.A Fulga V., Cismasiu, R.S. Goody, S.E. Szedlacsek: Intramolecular interactions in protein tyrosine phosphatase RPTPµ: Kinetic evidence. In: Biochem. Biophys. Res. Comm., 2001, 319-327