Prof. Dr. Melvin I. Simon

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietAllgemeine Genetik und funktionelle Genomforschung,Zellbiologie
KeywordsSignal Transduction in the visual system, Function of G-protein signalling circuits, Chemotaxis, ...

Aktuelle Kontaktadresse

Gastgeber*innen während der Förderung

Beginn der ersten Förderung01.12.1994

Programm(e)

1997Max Planck-Forschungspreis-Programm

Publikationen (Auswahl)

2003A. Moers, B. Nieswandt, S. Massberg, N. Wettschureck, S. Grüner, I. Konrad, V. Schulte, M.-P. Gratacap, M. I. Simon, M. Gawaz, S. Offermanns: G13 is an essential mediator of platelet activation in hemostasis and thrombosis. In: Nat. Med., 2003, 1418-1422
2002M. Miura, M. Watanabe, S. Offermanns, M. I. Simon, M. Kano: Group I metabotropic glutamate receptor signaling via G alpha q/ G alpha11 secures the induction of long-term potentiation in the hippocampal area CA1. In: Neurosci., 2002, 8379-8390
2002J.L. Gu, S. Müller, V. Mancino, S. Offermanns, M. I. Simon: Interaction of G alpha12 with G alpha13 and G alpha q signaling pathways. In: Proc. Natl. Acad. Sci. USA, 2002, 9352-9357
2001S. Offermanns, P. Negulescu, Y.-H. Hu, M. I. Simon: Condiotionally expressed G alpha 15 couples to endogenous receptors in GH3 cells. In: Naunyn Schmiedebergs Arch. Pharmacol., 2001, 140-148
2000H. Tsubokawa, S. Offermanns, M. Simon, M. Kano: Calcium-dependent persistent facilitation of spike backpropagation in the CA1 pyramidal neurons. In: J. Neurosci., 2000, 4878-4884
2000K. Hashimoto, M. Watanabe, H. Kurihara, S. Offermanns, H. Jiang, Y. Wu, K. Jun, H.S. Shin, Y. Inoue, D. Wu, M. I. Simon, M. Kano: Climbing fiber synapse elimination during postnatal cerebellar development requires signal transduction involving G alpha q and phospholipase C beta 4. In: Prog. Brain Res., 2000, 31-48
2000J.E. Haley, P. Delmas, S. Offermanns, F.C. Abogadie, M. I. Simon, N.J. Buckley, D.A. Brown: Muscarinic inhibtion of calcium current and M current in G alpha q-deficient mice. In: J. Neurosci., 2000, 3973-3979
1999B. Klages, U. Brandt, M. I. Simon, G. Schultz, S. Offermanns: Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. In: J. Cell. Biol., 1999, 745-754
1998S. Offermanns, L.-P. Zhao, A. Gohla, I. Sarosi, M. I. Simon, T.M. Wilkie: Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha11-mutant mice. In: EMBO J., 1998, 4304-4312
1998S. Offermanns, M. I. Simon: Genetic analysis of mammalian G-protein signalling. In: Oncogene, 1998, 1375-1381
1998M. Kano, K. Hashimoto, M. Watanabe, H. Kurihara, S. Offermanns, H. Jiang, Y. Wu, K. Jun, H.S. Shin, Y. Inoue, M. I. Simon, D. Wu: Phospholipase c beta4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. In: Proc. Natl. Acad. Sci. USA, 1998, 15724-15729