Dr. Heiko Rauer

Profil

Derzeitige StellungDerzeit ohne wiss. Stellung
FachgebietAnatomie und Physiologie,Biochemie
Keywordsd) Clinical studies, a) Ion channel, structural function,, b)Immunology, Ca 2t signaling,, c) Pharmacology (Adr.Blatt 1.2000)
Auszeichnungen

1998: Feodor-Lynen-Fellow

Aktuelle Kontaktadresse

LandDeutschland
OrtMünchen
Universität/InstitutionDaiichi-Sankyo Europe
Institut/AbteilungGlobal Oncology Medical Affairs Clinical Operations

Gastgeber*innen während der Förderung

Prof. Dr. Michael D. CahalanDepartment of Physiology & Biophysics, University of California, Irvine, Irvine
Beginn der ersten Förderung01.08.1998

Programm(e)

1998Feodor Lynen-Forschungsstipendien-Programm

Publikationen (Auswahl)

2001Fanger, C.M., Rauer, H., Neben, A.L., Miller, M.J., Rauer, H., Wulff, H., Rosa, J.C., Ganellin, C.R., Chandy, K.G. and M.D. Cahalan: Ca2+-activated K+ channels sustain Ca2+ signaling in T lymphocytes. In: Journal of Biological Chemistry, 2001, 12249-12256
2001Lanigan M.D., Pennington M.W., Lefievre Y., Rauer H. and R.S. Norton: Designed peptide analogues of the potassium channel blocker ShK toxin. In: Biochemistry, 2001, 15528-15537
2001Miller M.J., Rauer H., Tomita H., Rauer H., Gargus J..J, Gutman G.A., Cahalan M.D. and K.G. Chandy: Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia. In: Journal of Biological Chemistry, 2001, 27753-27756
1999Fanger, C.M., Ghanshani S., Logsdon N.J., Rauer H., Kalman K., Zhou J., Beckingham K., Chandy K.G., Cahalan M.D. and J. Aiyar: Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. In: Journal of Biological Chemistry, 1999, 5746-5754
1999Rauer H. and S. Grissmer: The effect of deep pore mutations on the action of phenylalkyl-amines on the Kv1.3 potassium channel. In: British Journal of Pharmacology, 1999, 1065-1074
1999Hanson D.C., Nguyen A., Mather R.J., Rauer H., Koch K., Burgess L.E., Rizzi J.P., Donovan C.B., Bruns M.J., Canniff P.C., Cunningham A.C., Verdries K.A., Mena E., Kath J.C., Gutman G.A., Cahalan M.D., Grissmer S., and K.G. Chandy: UK-78,282, a Novel Piperidine Compound that Potently Blocks the Kv1.3 Voltage-Gated Potassium Channel and Inhibits Human T Cell Activation. In: British Journal of Pharmacology, 1999, 1707-1716
1998Wulff H., Rauer H., Duering T., Hanselmann C., Ruff K., Wrisch A., Grissmer S. and W. Hansel: Alkoxypsoralens- Novel nonpeptide blockers of Shaker- type K+-channels: Synthesis and photoreactivity. In: Journal of Medicinal Chemistry, 1998, 4542-4549
1998Jäger H., Rauer H., Nguyen A.N., Aiyar J., Chandy K.G. and S. Grissmer: Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states. In: Journal of Physiology, 1998, 291-301
1998Kalman K., Pennington M.W., Lanigan M.D., Nguyen A., Rauer H., Mahnir V., Paschetto K., Kem W.R., Grissmer S.,Gutman G.A., Christian E.P., Cahalan, M.D., Norton R.S. and K.G. Chandy: ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. In: Journal of Biological Chemistry, 1998, 32697-32707
1996Nguyen A., Kath J. C., Hanson D.C., Biggers M.S., Cannif P.C., Donovan C.B., Mather R.J., Bruns M.J., Rauer H., Aiyar, J., Lepple-Wienhues A., Gutman G.A., Grissmer, S. Cahalan M.D. and K.G. Chandy: Novel nonpeptide agents potently block C-type inactivated conformation of Kv1.3 and suppress T cell activation. In: Molecular Pharmacology, 1996, 1672-1679