Prof. Dr. Katherine Thea Andrews

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietMedizinische Mikrobiologie und Mykologie und Hygiene, Molekulare Infektionsbiologie,Pharmakologie
Keywordsmalaria, P. falciparum, drug discovery, histone deacetylase, target identification

Aktuelle Kontaktadresse

LandAustralien
OrtNathan
Universität/InstitutionGriffith University
Institut/AbteilungGriffith Institute for Drug Discovery
Websitehttps://experts.fgriffith.edu.au/18823-katherine-andrews

Gastgeber*innen während der Förderung

Prof. Dr. Michael LanzerUniversitätsklinikum Heidelberg, Zentrum für Infektiologie, Ruprecht-Karls-Universität Heidelberg, Heidelberg
Beginn der ersten Förderung01.09.1999

Programm(e)

1999Humboldt-Forschungsstipendien-Programm

Publikationen (Auswahl)

2011Marfurt, J. Chalfein, F. Prayoga, P. Wabiser, F. Kenangalem, E. Piera, K. A. Fairlie, D. P. Tjitra, E. Anstey, N. M. Andrews, K. T. Price, R. N.: Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. In: Antimicrob Agents Chemother, 2011, 961-966
2011Xu, M. Andrews, K. T. Birrell, G. W. Tran, T. L. Camp, D. Davis, R. A. Quinn, R. J.: Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina. In: Bioorg Med Chem Lett, 2011, 846-848
2011Devakaram, R. Black, D. S. Andrews, K. T. Fisher, G. M. Davis, R. A. Kumar, N.: Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives. In: Bioorg Med Chem, 2011, 5199-5206
2010Loser, R. Gut, J. Rosenthal, P. J. Frizler, M. Gutschow, M. Andrews, K. T.: Antimalarial activity of azadipeptide nitriles. In: Bioorg Med Chem Lett, 2010, 252-255
2010Peatey, C. L. Andrews, K. T. Eickel, N. MacDonald, T. Butterworth, A. S. Trenholme, K. R. Gardiner, D. L. McCarthy, J. S. Skinner-Adams, T. S.: Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors. In: Antimicrob Agents Chemother, 2010, 1334-1337
2010Wheatley, N. C. Andrews, K. T. Tran, T. L. Lucke, A. J. Reid, R. C. Fairlie, D. P.: Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components. In: Bioorg Med Chem Lett, 2010, 7080-7084
2010Oster, N. Rohrbach, P. Sanchez, C. P. Andrews, K. T. Kammer, J. Coulibaly, B. Stieglbauer, G. Becher, H. Lanzer, M.: Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta. In: Parasitol Res, 2010, 1065-1070
2010Davis, R. A. Carroll, A. R. Andrews, K. T. Boyle, G. M. Tran, T. L. Healy, P. C. Kalaitzis, J. A. Shivas, R. G.: Pestalactams A-C: novel caprolactams from the endophytic fungus Pestalotiopsis sp. In: Org Biomol Chem, 2010, 1785-1790
2009Brentlinger, P. E. Behrens, C. B. Micek, M. A. Steketee, R. W. Andrews, K. T. Skinner-Adams, T. S. Gardiner, D. L. McCarthy, J. S. Parikh, S. ter Kuile, F. Ayisi, J.: Plagiarism. In: Trans R Soc Trop Med Hyg, 2009, 855
2009Gardiner, D. L. Skinner-Adams, T. S. Brown, C. L. Andrews, K. T. Stack, C. M. McCarthy, J. S. Dalton, J. P. Trenholme, K. R.: Plasmodium falciparum: new molecular targets with potential for antimalarial drug development. In: Expert Rev Anti Infect Ther, 2009, 1087-1098
2009Andrews, K. T. Tran, T. N. Wheatley, N. C. Fairlie, D. P.: Targeting histone deacetylase inhibitors for anti-malarial therapy. In: Curr Top Med Chem, 2009, 292-308
2008Fernandez, L. S. Jobling, M. F. Andrews, K. T. Avery, V. M.: Antimalarial activity of natural product extracts from Papua New Guinean and Australian plants against Plasmodium falciparum. In: Phytother Res, 2008, 1409-1412
2008Dow, G. S. Chen, Y. Andrews, K. T. Caridha, D. Gerena, L. Gettayacamin, M. Johnson, J. Li, Q. Melendez, V. Obaldia, N., 3rd Tran, T. N. Kozikowski, A. P.: Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. In: Antimicrob Agents Chemother, 2008, 3467-3477
2008Yosaatmadja, F. Andrews, K. T. Duffy, M. F. Brown, G. V. Beeson, J. G. Rogerson, S. J.: Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line. In: Malar J, 2008, 51
2008Skinner-Adams, T. S. McCarthy, J. S. Gardiner, D. L. Andrews, K. T.: HIV and malaria co-infection: interactions and consequences of chemotherapy. In: Trends Parasitol, 2008, 264-271
2008Andrews, K. T. Tran, T. N. Lucke, A. J. Kahnberg, P. Le, G. T. Boyle, G. M. Gardiner, D. L. Skinner-Adams, T. S. Fairlie, D. P.: Potent antimalarial activity of histone deacetylase inhibitor analogues. In: Antimicrob Agents Chemother, 2008, 1454-1461
2008Lek-Uthai, U. Suwanarusk, R. Ruengweerayut, R. Skinner-Adams, T. S. Nosten, F. Gardiner, D. L. Boonma, P. Piera, K. A. Andrews, K. T. Machunter, B. McCarthy, J. S. Anstey, N. M. Price, R. N. Russell, B.: Stronger activity of human immunodeficiency virus type 1 protease inhibitors against clinical isolates of Plasmodium vivax than against those of P. falciparum. In: Antimicrob Agents Chemother, 2008, 2435-2441
2007Redmond, A. M. Skinner-Adams, T. Andrews, K. T. Gardiner, D. L. Ray, J. Kelly, M. McCarthy, J. S.: Antimalarial activity of sera from subjects taking HIV protease inhibitors. In: AIDS, 2007, 763-765
2007Adams, Y. Schwartz-Albiez, R. McCarthy, J. S. Andrews, K. T.: Effect of cytokine treatment on the in vitro expression of the P. falciparum adhesion receptor chondroitin-4-sulphate on the surface of human choriocarcinoma (BeWo) cells. In: Parasitol Res, 2007, 479-483
2007Schwartz-Albiez, R. Adams, Y. von der Lieth, C. W. Mischnick, P. Andrews, K. T. Kirschfink, M.: Regioselectively modified sulfated cellulose as prospective drug for treatment of malaria tropica. In: Glycoconj J, 2007, 57-65
2007Beeson, J. G. Andrews, K. T. Boyle, M. Duffy, M. F. Choong, E. K. Byrne, T. J. Chesson, J. M. Lawson, A. M. Chai, W.: Structural basis for binding of Plasmodium falciparum erythrocyte membrane protein 1 to chondroitin sulfate and placental tissue and the influence of protein polymorphisms on binding specificity. In: J Biol Chem, 2007, 22426-22436
2007Skinner-Adams, T. S. Andrews, K. T. Melville, L. McCarthy, J. Gardiner, D. L.: Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro. In: Antimicrob Agents Chemother, 2007, 759-762
2007Dunn, L. A. Andrews, K. T. McCarthy, J. S. Wright, J. M. Skinner-Adams, T. S. Upcroft, P. Upcroft, J. A.: The activity of protease inhibitors against Giardia duodenalis and metronidazole-resistant Trichomonas vaginalis. In: Int J Antimicrob Agents, 2007, 98-102
2006Lee, N. Baker, J. Andrews, K. T. Gatton, M. L. Bell, D. Cheng, Q. McCarthy, J.: Effect of sequence variation in Plasmodium falciparum histidine- rich protein 2 on binding of specific monoclonal antibodies: Implications for rapid diagnostic tests for malaria. In: J Clin Microbiol, 2006, 2773-2778
2006Adams, Y. Freeman, C. Schwartz-Albiez, R. Ferro, V. Parish, C. R. Andrews, K. T.: Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides. In: Antimicrob Agents Chemother, 2006, 2850-2852
2006Andrews, K. T. Fairlie, D. P. Madala, P. K. Ray, J. Wyatt, D. M. Hilton, P. M. Melville, L. A. Beattie, L. Gardiner, D. L. Reid, R. C. Stoermer, M. J. Skinner-Adams, T. Berry, C. McCarthy, J. S.: Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria. In: Antimicrob Agents Chemother, 2006, 639-648
2005Andrews, K. T. Adams, Y. Viebig, N. K. Lanzer, M. Schwartz-Albiez, R.: Adherence of Plasmodium falciparum infected erythrocytes to CHO-745 cells and inhibition of binding by protein A in the presence of human serum. In: Int J Parasitol, 2005, 1127-1134
2005Abdel-Aziz, I. Z. Oster, N. Stich, A. Coulibaly, B. Guigemde, W. A. Wickert, H. Andrews, K. T. Kouyate, B. Lanzer, M.: Association of Plasmodium falciparum isolates encoding the p. Falciparum chloroquine resistance transporter gene K76T polymorphism with anemia and splenomegaly, but not with multiple infections. In: Am J Trop Med Hyg, 2005, 252-255
2005Adams, Y. Smith, S. L. Schwartz-Albiez, R. Andrews, K. T.: Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36. In: Parasitol Res, 2005, 290-294
2005Oster, N. Abdel-Aziz, I. Z. Stich, A. Coulibaly, B. Kouyate, B. Andrews, K. T. McLean, J. E. Lanzer, M.: Comparison of different PCR protocols for the detection and diagnosis of Plasmodium falciparum. In: Parasitol Res, 2005, 424-428
2005Viebig, N. K. Wulbrand, U. Forster, R. Andrews, K. T. Lanzer, M. Knolle, P. A.: Direct activation of human endothelial cells by Plasmodium falciparum-infected erythrocytes. In: Infect Immun, 2005, 3271-3277
2005Viebig, N. K. Andrews, K. T. Kooyk, Yv Lanzer, M. Knolle, P. A.: Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytes. In: Parasitol Res, 2005, 247-252
2005Andrews, K. T. Klatt, N. Adams, Y. Mischnick, P. Schwartz-Albiez, R.: Inhibition of chondroitin-4-sulfate-specific adhesion of Plasmodium falciparum-infected erythrocytes by sulfated polysaccharides. In: Infect Immun, 2005, 4288-4294
2004Skinner-Adams, T. S. McCarthy, J. S. Gardiner, D. L. Hilton, P. M. Andrews, K. T.: Antiretrovirals as antimalarial agents. In: J Infect Dis, 2004, 1998-2000
2003Katherine Thea Andrews, N. K. Viebig, F. Wissing, N. Klatt, N. Oster, H. Wickert, P. Knolle, M. Lanzer: A human schwannoma cell line supports the in vitro adhesion of Plasmodium falciparum infected erythrocytes to chondroitin-4-sulfate. In: Parasitol Res., 2003, 188-193
2003Wickert, H. Wissing, F. Andrews, K. T. Stich, A. Krohne, G. Lanzer, M.: Evidence for trafficking of PfEMP1 to the surface of P. falciparum-infected erythrocytes via a complex membrane network. In: Eur J Cell Biol, 2003, 271-284
2003Andrews, K. T. Pirrit, L. A. Przyborski, J. M. Sanchez, C. P. Sterkers, Y. Ricken, S. Wickert, H. Lepolard, C. Avril, M. Scherf, A. Gysin, J. Lanzer, M.: Recovery of adhesion to chondroitin-4-sulphate in Plasmodium falciparum varCSA disruption mutants by antigenically similar PfEMP1 variants. In: Mol Microbiol, 2003, 655-669
2003Przyborski, J. M. Bartels, K. Lanzer, M. Andrews, K. T.: The histone H4 gene of Plasmodium falciparum is developmentally transcribed in asexual parasites. In: Parasitol Res, 2003, 387-389
2002Katherine Thea Andrews, Michael Lanzer: Maternal malaria: Plasmodium falciparum sequestration in the placenta. In: Parasitol Res, 2002, 715-723
2000Andrews, K. T. Walduck, A. Kelso, M. J. Fairlie, D. P. Saul, A. Parsons, P. G.: Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents. In: Int J Parasitol, 2000, 761-768
2000Collins, W. E. Walduck, A. Sullivan, J. S. Andrews, K. Stowers, A. Morris, C. L. Jennings, V. Yang, C. Kendall, J. Lin, Q. Martin, L. B. Diggs, C. Saul, A.: Efficacy of vaccines containing rhoptry-associated proteins RAP1 and RAP2 of Plasmodium falciparum in Saimiri boliviensis monkeys. In: Am J Trop Med Hyg, 2000, 466-479
2000Baldi, D. L. Andrews, K. T. Waller, R. F. Roos, D. S. Howard, R. F. Crabb, B. S. Cowman, A. F.: RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum. In: EMBO J, 2000, 2435-2443
1998Andrews, K. T. Patel, B. K. Clarke, F. M.: FgoI, a Type II restriction endonuclease from the thermoanaerobe Fervidobacterium gondwanense AB39(T). In: Anaerobe, 1998, 227-132
1998Andrews, K. T. Wolter, L. C. Saul, A. Hyland, C. A.: The RhD- trait in a white patient with the RhCCee phenotype attributed to a four-nucleotide deletion in the RHD gene. In: Blood, 1998, 1839-1840