Prof. Dr. Christopher Rose

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietMolekulare Biologie und Physiologie von Nerven- und Gliazellen,Klinische Neurologie; Neurochirurgie und Neuroradiologie,Gastroenterologie
KeywordsHepatic encephalopathy, Ammonia, Oxidative stress, Brain edema, Blood brain barrier

Aktuelle Kontaktadresse

LandKanada
OrtMontreal
Universität/InstitutionUniversite de Montreal
Institut/AbteilungCRCHUM - Hepato-Neuro Laboratory

Gastgeber*innen während der Förderung

Prof. Dr. Helmut KettenmannZelluläre Neurobiologie, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin
Prof. Dr. Helmut KettenmannForschungsgruppe Zelluläre Neurowissenschaften, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin
Beginn der ersten Förderung01.03.2001

Programm(e)

2000Humboldt-Forschungsstipendien-Programm

Publikationen (Auswahl)

2011Cristina R Bosoi, Christian Parent-Robitaille, K Anderson, Mélanie Tremblay and Christopher Rose: “AST-120 (spherical carbon adsorbent) lowers ammonia levels and attenuates brain edema in bile duct-ligated rats.”. In: Hepatology, 2011, 1995-2002
2010Christopher Rose: “Increase brain lactate in hepatic encephalopathy: Cause or consequence?” . In: Neurochemistry International, 2010, 389-394
2010R.G Kristiansen, S Lindal, K Myreng, A Revhaug, L.M Ytrebø and Christopher Rose: “Neuropathological changes in the brain of pigs with acute liver failure.”. In: Scandinavian Journal of Gastroenterology, 2010, 935-943
2010X Yang, Cristina R Bosoi, W Jiang, Mélanie Tremblay and Christopher Rose: “Portacaval anastomosis-induced hyperammonemia does not lead to oxidative stress.”. In: Metabolical Brain Disease, 2010, 11-15
2009Cristina R Bosoi and Christopher Rose: “Identifying the direct effects of ammonia on the brain.” . In: Metabolical Brain Disease, 2009, 95-102
2009L.M Ytrebø, R.G Kristiansen, H Maehre, O.M Fuskevåg, T Kalstad, A Revhaug, M.J Cobos, R Jalan and Christopher Rose: “L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure.” . In: Hepatology, 2009, 165-174
2007Christopher Rose, L.M Ytrebø, N.A Davies, S Sen, G.I Nedredal, Mireille Bélanger, A Revhaug and R Jalan “Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.” . In: Hepatology, 2007, 1883-1892
2006N Chatauret, Paul Desjardins, Claudia Zwingmann, Christopher Rose, K.V Rao and Roger F Butterworth: “Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.” . In: Journal of Hepatology, 2006, 1083-1088
2006S Sen, Christopher Rose, L.M Ytrebø, N.A Davies, G.I Nedredal, S.S Drevland, M Kjønnø, F.W Prinzen, S.J Hodges, N.E.P Deutz, R Williams, R Butterworth, A Revhaug and R Jalan “Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.” . In: Critical Care Medicine, 2006, 158-164
2006Christopher Rose: “Effect of ammonia on astrocytic glutamate uptake/release mechanisms.” . In: Journal of Neurochemistry, 2006, 11-15
2006L.M Ytrebo, S Sen, Christopher Rose, G.A.M.T Have, N.A Davies, S Hodges, G.I Nedredal, M Romero-Gomez, R Williams, A Revhaug, R Jalan and N.E.P Deutz: “Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure.” . In: Journal of Physiology Gastrointestinal Liver Physiology, 2006, G373-G381
2006L.M Ytrebø, S Sen, Christopher Rose, N.A Davies, G.I Nedredal, O-M Fuskevaag, G.A.M.T Have, F.W Prinzen, R Williams, N.E.P Deutz, R Jalan and A Revhaug “Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis.” . In: Scandinavian Journal of Gastroenterology, 2006, 1350-1360
2005Christopher Rose, W Kresse and H Kettenmann: “Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.”. In: Journal of Biological Chemistry, 2005, 20937-20944
2005Javier Vaquero, Christopher Rose and Roger F. Butterworth: “Keeping cool in acute liver failure: rationale for the use of mild hypothermia.”. In: Journal of Hepatology, 2005, 1067-1077
2005Christopher Rose and V Felipo: “Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide.” . In: Metabolic Brain Disease, 2005, 275-283
2005Mireille Bélanger, Paul Desjardins, N Chatauret, Christopher Rose and Roger Butterworth: “Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure.” . In: Journal of Hepatology, 2005, 694-699