Prof. Dr. Vadim Sumbayev

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietBiochemie,Immunologie
KeywordsAnti-cancer immunity, Immune evasion, Immunotherapy of Cancer, cancer, hypoxia

Aktuelle Kontaktadresse

LandVereinigtes Königreich
OrtGillingham
Universität/InstitutionUniversity of Kent at Medway
Institut/AbteilungMedway School of Pharmacy

Gastgeber*innen während der Förderung

Prof. Dr. Bernhard BrüneFachbereich Biologie, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau (RPTU), Kaiserslautern
Beginn der ersten Förderung01.11.2001

Programm(e)

2001Humboldt-Forschungsstipendien-Programm

Publikationen (Auswahl)

2008Harjinder Lall, Karen Coughlan, & Vadym Sumbayev: HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6. In: Molecular Immunology, 2008, 3045-3049
2008Vadym Sumbayev: LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein.. In: FEBS Letters, 2008, 319-326
2008Vadym Sumbayev, Jan Jensen, Jacob Hansen, Peter Andreasen: Novel modes of oestrogen receptor agonism and antagonism by hydroxylated and chlorinated biphenyls, revealed by conformation-specific peptide recognition patterns. In: Molecular and Cellular Endocrinology, 2008, 30-39
2008Vadym Sumbayev: PI3 kinase and direct S-nitrosation are involved in down-regulation of apoptosis signal-regulating kinase 1 during LPS-induced Toll-like receptor 4 signalling.. In: Immunology Letters, 2008, 126-130
2008Vadym Sumbayev, Inna Yasinska: Protein S-nitrosation in signal transduction: assays for specific qualitative and quantitative analysis. In: Methods in Enzymology, 2008, 209-219
2007Jacob Ask Hansen, Vadym Sumbayev, Kurt Gothelf: An electrochemical sensor based on the human estrogen receptor ligand binding domain.. In: NANO Letters, 2007, 2831-2834
2007Vadym Sumbayev, Inna Yasinska: Mechanisms of hypoxic signal transduction regulated by reactive nitrogen species.. In: Scand. J Immunol, 2007, 399-406
2006Anna V. Kozhukhar, Inna M. Yasinska and Vadym Sumbayev: Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron.. In: Biochimie, 2006, 411-418
2006Vadym Sumbayev, Inn Yasinska: Peroxynitrite as an alternative donor of oxygen in HIF-1á proline hydroxylation under low oxygen availability . In: Free Radical Research, 2006, 631-635
2006Vadym Sumbayev, Inna Yasinska: Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection. In: Scandinavian Journal of Immunology, 2006, 391-400
2005Vadym Sumbayev, Eva C. Bonefeld-Jorgensen, Troels Wind, Peter A. Andreasen: A novel pesticide-induced conformational state of the oestrogen receptor ligand-binding domain, detected by conformation-specific peptide binding. In: FEBS Letters, 2005, 541-548
2005Rupa Mukhopadhyay, Vadym Sumbayev, Martin Lorentzen, Jorgen Kjems, Peter Andreasen, Flemming Besenbacher: Cantilever sensor for nanomechanical detection of specific protein conformations. . In: NANO Letters, 2005, 2385-2388
2005Vadym Sumbayev, Inna Yasinska: Regulation of MAP kinase-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species . In: Arch. Biochem. Biophys., 2005, 406-412
2004Inna Yasinska, Anna Kozhukhar, Vadym Sumbayev: S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1.. In: Archives of Biochemistry and Biophysics, 2004, 198-203
2003Vadym Sumbayev, Andreja Budde, Jie Zhou and Bernhard Brüne: HIF-1alpha protein is a target for S-nitrosation. In: FEBS Letters, 2003, 106-112
2003Vladimir Shatrov, Vadym Sumbayev, Jie Zhou, Bernhard Brüne: Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. . In: Blood, 2003, 4847-4849
2003Inna Yasinska, Vadym Sumbayev: S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity. . In: FEBS Letters, 2003, 105-109
2003Vadym Sumbayev: Vadym V. Sumbayev. In: S-nitrosylation of thioredoxin mediates activation of apoptosis signal-regulating kinase 1. In: Archives of Biochemistry and Biophysics, 2003, 133-136
2002I. M. Yasinska, Vadym Sumbayev: Ascorbic Acid (AA) and Gluthathione-SH (GSH) Inhibit NO-dependent Activation of Apoptosis Signal-Regulating Kinase (ASK)1. In: Nitric Oxide, 2002, 491
2002Vadym Sumbayev: Effects of nitric oxide donors on apoptosis signal regulating kinase 1, protein kinase C, PARP and activities in rat liver in vivo. In: Herald of Kiev National University, 2002, 35-36
2002Vadym Sumbayev, Bernhard Brüne: Glutathione determines the response of mesangial cells and hepatocytes to nitric oxide and peroxynitrite. In: Nitric oxide biology and chemistry, 2002, 469-470
2002Vadym Sumbayev, Katrin Sandau, Bernhard Brüne: Mesangial cells but not hepatocytes are protected against NO/O2- cogeneration: mechanistic considerations. In: European Journal of Pharmacology, 2002, 1-11
2002Vadym Sumbayev, I. M. Yasinska Molecular mechanisms of regulation of MAP-kinase apoptotic pathway y nitric oxide and reactive oxygen species LAMSO. In: LAMSO, 2002, 1-11
2002Vadym Sumbayev: Nitric oxide synthase, apoptosis signal regulating kinase 1, poly-(ADO-ribose)-polymerase, protein kinase C, serine proteinases activity and DNA fragmentation in rat liver during molybden-dependent induction of xanthine oxidase. In: Ukrainian Biochemical Journal, 2002, 73-76
2002Vadym Sumbayev, I. M. Yasinska: Phenobarbital effect on xanthine oxidase, nitric oxide synthase and protein kinase C activities. In: Modern Problems of Toxicology, 2002, 21-26
2002Vadym Sumbayev, I. M. Yasinska: Reactive oxygen species- and NO-dependent regulation of apoptosis signal regulating kinase 1. In: Ukrainian Biochemical Journal, 2002, 83
2002T. B. Studinskaya, O. V. Karpova, O. V. Benderskaya, Vadym Sumbayev, Redox- and NO-dependent regulation of NP-synthase, PARP and protein kinase C activities. In: Ukrainian Biochemical Journal, 2002, 231
2002O. v. Benderskaya, Vadym Sumbayev: Redox-dependent regulation of cytochrome P450 isoforms 1A1, 1A2 and 1B1. In: Ukarinian Biochemical Journal, 2002, 124
2002Vadym Sumbayev, I. M. Yasinska, Y. O. Voskresenskaya: The concentrations of some steroid hormones, purine catabolism products and nitric oxide aerobic oxidation intermediates in blood serum of women's from the regions polluted by polychlorinated biphenils. In: Modern Problems of Toxicology, 2002, 32-36
2002Vadym Sumbayev, I. M. Yasinska: Xanthine oxidase, nitric oxide synthase, and protein kinase c activities as well as cytochrome P450 1A1, 1A2 and 1B1 quantities in the rat liver under conditios of CoC12 induced oxidative stress. In: Ukrainian Biochemical Journal, 2002, 117-120
2002Vadym Sumbayev, I. M. Yasinska: the induction of cytochrome p450 1A1,1A2 and 1B1 isoforms as well as poly-(ADP-ribose)-polymerase activativation in the rat liver caused by fitoestrogens-genistein and daidsein. In: Modern Problems of Toxicology, 2002, 25-28
2001Vadym Sumbayev, I. M. Yasinska Activity of the glutahtione antioxidant system and dytochrome P-450 in rat liver under induction and inhibition of xanthine oxidase. In: Ukrainian Biochemical Journal, 2001, 79-82
2001Vadym Sumbayev: Genistein effect on xanthine oxidase activity. In: Ukrainian Biochemical Journal, 2001, 39-43
2001Vadym Sumbayev: NO activates MAP-kinase cascade in neurons. In: TNA Sci. Remarks, 2001, 169-173
2001Vadym Sumbayev, I. M. Yasinska: Nitric oxide activates apoptosis signal-regulating kinase 1 (ASK 1) forming S-nitrosolthiols with reactive thioredoxin SH-groups. Nitric oxide synthase (NOS) induction mediated inhibition of poly-(ADP-ribose)-polymerase (PARP) and protein as ... . In: The Scientific World, 2001, 118
2001Vadym Sumbayev, O. V. Karpova, T. B. Studinskaya: Nitric oxide synthase, poly-(ADP-ribose)-polymerase, protein kinase C and apoptosis signal-regulatin kinase 1 (ASK 1), activities as well as internucleosomal dna fragmentation in the HEP-2 cells under conditions of Mo-dependent xanthine oxidase activation. In: Ukarinian Biochemical Journal, 2001, 119-122
2001Vadym Sumbayev, I. M. Yasinska: Novel mechanisms of nitric oxide mediated apoptosis. In: Eur. J. Biochem., 2001, 66
2001Vadym Sumbayev, I. M. Yasinska: Poly - (ADP-ribose)-polymerase and protein kinase C activities as well as intranucleosomal DNA fragmentation in the HEP-2 cells (human larynx cancer cells) treated by human gama-interferon in the presence and absence of allopurinol. In: Exp. Oncol., 2001, 294-296
2001I. M. Yasinska, Vadym Sumbayev: The activities of aromatase, cytochrome P450 isoforms inducible by xenoestrogens (1A1, 1A2 and 1B1) as well as nitric oxide synthase in the rat organism under conditions of cobalt chloride mediated oxidative stress. In: Eur. J. Biochem., 2001, 66
2001Vadym Sumbayev: The activity of apoptosis signal regulatin kinase, poly-(ADP-ribose)-polymerase and intranucleosolam DNA fragmentation in the case of CoC12 mediated oxidative stress. In: Bull. Exper. Biol. Med., 2001, 119-120
2001Vadym Sumbayev: The effects of ascorbic acid and glutathione-SH on thioredoxin reactive SH-groups sensitivity to nirosylation. In: LAMSO, 2001, 1-6
2001Vadym Sumbayev, I. M. Yasinska: Xanthine oxidase, nitric oxide synthase and aromatase activities as well as sytochrome P450 1A1, 1A2 and 1B1 level in rat organism under conditions of parental genistein injections. In: Biopolymers and cell, 2001, 396-400
2001Vadym Sumbayev: Xanthine oxidase, nitric oxide synthase, apoptosis signal regulatin kinase 1, poly-(ADP-ribose)-polymerase and protein kinase c activities as well as DNa fragmentation in the rat liver under conditions of clotrimazol injections. In: LAMSO, 2001, 1-12