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Prof. Dr. Stephen High

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietBiochemie,Zellbiologie
KeywordsEndoplasmic reticulum, chaperones, cross-linking, membrane proteins, quality control

Aktuelle Kontaktadresse

LandVereinigtes Königreich
OrtManchester
Universität/InstitutionUniversity of Manchester
Institut/AbteilungFaculty of Life Sciences, Michael Smith Building
Websitehttp://www.ls.manchester.ac.uk/people/profile/index.aspx?PersonID=802

Gastgeber*innen während der Förderung

Prof. Dr. Bernhard DobbersteinZentrum für Molekulare Biologie Heidelberg (ZMBH), Ruprecht-Karls-Universität Heidelberg, Heidelberg
Beginn der ersten Förderung01.05.2001

Programm(e)

2001Friedrich Wilhelm Bessel-Forschungspreis-Programm

Projektbeschreibung der*des Nominierenden

Proteins which are destined for export out of the cell or intergration into membrnes are insereted during their synthesis in the cell cytosol into the membrane of the endoplasmic reticulum (ER). Professor High has developed a method by which molecular mechanisms of protein insertion into the ER membrane can be inverstigated. Now, he wants to elucidate the mechnism by which a cell controls the quality of the proteins inserted into a membrane. This process is important as misfolded proteins are not transported to their place of function. Cystic fibrosis is, for instance, a disease by which a protein of the plasma membrane gets stuck in the ER membrane and is, therefore, not able to perform its function in the plasma membrane.

Publikationen (Auswahl)

2010Pawel Leznicki Anne Clancy Blanche Schwappach Stephen High: Bat3 promotes the membrane integration of tail-anchored proteins. J. Cell Sci. 123: 2170-2178.. In: Journal of Cell Science, 2010, 2170-2178
2009Ben C.S. Cross Irmi Sinning Joen Luirink Stephen High: Delivering proteins for export from the cytosol . In: Nature Reviews Molecular Cell Biology, 2009, 255-264
2009Peri Roboti Lisa Swanton Stephen High: Differences in endoplasmic reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein . In: Journal of Cell Science, 2009, 3942-3953
2009Ben C.S. Cross Stephen High: Dissecting the physiological role of selective TM retention at the ER translocon. In: Journal of Cell Science, 2009, 1768-1777
2009Ben C.S. Cross Craig McKibbin Anna C. Callan Peri Roboti Michela Piacenti Catherine Rabu Cornelia M. Wilson Roger Whitehead Sabine L. Flitsch Martin R. Pool Stephen High Lisa Swanton: Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum. J. Cell Sci. 122: 4393-4400.. In: Journal of Cell Science, 2009, 4393-4400
2009Catherine Rabu Volker Schmid Blanche Schwappach Stephen High: Tail-anchored protein biogenesis – the beginning for the end? . In: Journal of Cell Science, 2009, 3605-3612
2008Catherine Rabu Peter Wipf Jeff L. Brodsky Stephen High: A precursor specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. In: Journal of Biological Chemistry, 2008, 27504-27513
2008Cornelia M. Wilson Quentin Roebuck Stephen High: Ribophorin I regulates substrate delivery to the oligosaccharyl-transferase core. In: PNAS USA, 2008, 9534-9539
2007Benjamin M. Abell Catherine Rabu Pawel Leznicki Jason C. Young Stephen High: Posttranslational integration of tail-anchored proteins is facilitated by defined molecular chaperones. In: Journal of Cell Science, 2007, 1743-1751
2007Benjamin M. Abell Catherine Rabu Pawel Leznicki Jason C. Young Stephen High: Posttranslational integration of tail-anchored proteins is facilitated by defined molecular chaperones.. In: Journal of Cell Science, 2007, 1743-1751
2007Cornelia M. Wilson Stephen High: Ribophorin I acts as a substrate specific facilitator of N-glycosylation . In: Journal of Cell Science, 2007, 648-657
2006Nurzian Ismail Samuel G. Crawshaw Stephen High : Active and passive displacement of transmembrane domains both occur during opsin biogenesis at the Sec61 translocon . In: Journal of Cell Science, 2006, 2826-2836
2005Eileithyia Swanton Andrew Holland Stephen High Philip Woodman: Disease-associated mutations cause premature oligomerization of myelin proteolipid protein in the endoplasmic reticulum.. In: Proceedings of the National Academy of Sciences (USA) , 2005, 4342-4347
2005Cornelia M. Wilson Claudine Kraft Claire Duggan Nurzian Ismail Samuel G. Crawshaw Stephen High: Ribophorin I associates with a subset of membrane proteins after their integration at the Sec61 translocon. . In: Journal of Biological Chemistry, 2005, 4195-4206
2004Benjamin M. Abell Martin R. Pool Oliver Schlenker Irmgard Sinning Stephen High: Signal recognition particle mediates post-translational targeting in eukaryotes. . In: EMBO Journal, 2004, 2755-2764
2003Eileithyia Swanton Stephen High Philip G. Woodman: Role of calnexin in the glycan-independent quality control of proteolipid protein. . In: EMBO Journal, 2003, 2948-2958
2002Suzanna L. Meacock Fabienne J.L. Lecomte Samuel G. Crawshaw Stephen High : Different transmembrane domains associate with distinct ER components during the membrane integration of a polytopic protein. . In: Molecular Biology of the Cell, 2002, 4114-4129
2002Benjamin M. Abell Stephen High Maurice M. Moloney : Membrane protein topology of oleosin is constrained by its long hydrophobic domain. . In: Journal of Biological Chemistry, 2002, 8602-8610