Prof. Dr. Michele Solimena

Profil

Derzeitige StellungProfessor W-3 und Äquivalente
FachgebietZellbiologie,Endokrinologie, Diabetologie, Metabolismus
KeywordsDiabetes, Exocytosis, Gene expression, Pancreatic islets, Signal transduction

Aktuelle Kontaktadresse

LandDeutschland
OrtDresden
Universität/InstitutionTechnische Universität Dresden
Institut/AbteilungPaul Langerhans Institute Dresden
Websitewww.islets.de

Gastgeber*innen während der Förderung

Prof. Dr. Hans-Detlev SaegerMedizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden
Prof. Dr. Kai L. SimonsMax-Planck-Institut für molekulare Zellbiologie und Genetik, Dresden
Beginn der ersten Förderung01.10.2001

Programm(e)

2001Wolfgang Paul-Forschungspreis-Programm

Projektbeschreibung der*des Nominierenden

Michele Solimena is a pioneer in applying molecular cell biology to the understanding of disease-related problems. He was the first to identify autoantigens associated with neurological disorders and diabetes. His research has also allowed a better comprehension of how neurons and endocrine cells communicate These studies have provided novel insight into the autoimmune pathogenic mechanisms of these diseases and form the basis for the development of new diagnostic and therapeutic procedures.

Publikationen (Auswahl)

2006Klaus-Peter Knoch, Ronny Meisterfeld, Stephan Kersting, Hendrik Bergert, Anke Altkrüger, Carolin Wegbrod, Melanie Jäger, Hans-Detlev Saeger, Michele Solimena: cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells. In: Cell Metabolism, 2006, 123-134
2005Hye-Won Shin, Mitsuko Hayashi, Savvas Christoforidis, Sandra Lacas-Gervais, Sebastian Hoepfner, Markus R. Wenk, Jan Modregger, Sandrine Uttenweiler-Joseph, Matthias Wilm, Arne Nystuen, Wayne N. Frankel, Michele Solimena, Pietro De Camilli, Marino Zerial: An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway . In: The Journal of Cell Biology, 2005, 607-618
2005Hendrik Bergert, Klaus-Peter Knoch, Ronny Meisterfeld, Melanie Jäger, Joke Ouwendijk, Stephan Kersting, Hans-Detlev Saeger, Michele Solimena: Effect of oxygenated perfluorocarbons on isolated rat pancreatic islets in culture. In: Cell Transplantation, 2005, 441-448
2004Yang Yang, Sandra Lacas-Gervais, D. Kent Morest, Michele Solimena, Matthew N. Rasband: BetaIV Spectrins Are Essential for Membrane Stability and the Molecular Organization of Nodes of Ranvier. In: Journal of Neuroscience, 2004, 7230-7240
2004Sandra Lacas-Gervais, Jun Guo, Nicola Strenzke, Eric Scarfone, Melanie Kolpe, Monika Jahkel, Pietro De Camilli, Tobias Moser, Matthew N. Rasband, Michele Solimena BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments. In: The Journal of Cell Biology, 2004, 983-990
2004Beth B. Murinson, Margaret Butler, K. Marfurt, S. Gleason, Pietro De Camilli, Michele Solimena: Markedly elevated GAD antibodies in SPS: Effects of age and illness duration . In: Neurology, 2004, 2146-2148
2004Mirko Trajkovski, Hassan Mziaut, Anke Altkrüger, Joke Ouwendijk, Klaus-Peter Knoch, Stefan Müller, Michele Solimena Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in Beta-cells . In: The Journal of Cell Biology, 2004, 1063-1074
2004Klaus-Peter Knoch, Hendrik Bergert, Barbara Borgonovo, Hans-Detlev Saeger, Anke Altkrüger, Paul Verkade, Michele Solimena: Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. In: Nature Cell Biology, 2004, 207-214
2004Gabor C. Petzold, Melissa Marcucci, Margaret H. Butler, Frank K. H. van Landeghem, Karl M. Einhäupl, Michele Solimena, José M. Valdueza, Pietro De Camilli: Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. In: Annals in Neurology, 2004, 286-290
2003Folker Spitzenberger, Susan Pietropaolo, Paul Verkade, Bianca Habermann, Sandra Lacas-Gervais, Hassan Mziaut, Massimo Pietropaolo, Michele Solimena: Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. In: The Journal of Biological Chemistry , 2003, 26166-26173
2003Michele Solimena, Hans-Hermann Gerdes: Secretory granules: and the last shall be first. In: Trends in cell Biology, 2003, 399-402
2002Klaus Schmierer, Pascal Grosse, Pietro De Camilli, Michele Solimena, Scott Floyd, Rolf Zschenderlein: Paraneoplastic stiff-person syndrome: No tumor progression over 5 years. In: Neurology, 2002, 148-148