Dr. Zareen Amtul

Profil

Derzeitige StellungPost Doc
FachgebietBiochemie,Zellbiologie
KeywordsAlzheimer's disease, Aß metabolim , Gamma secretase, cancer, lipids

Aktuelle Kontaktadresse

Gastgeber*innen während der Förderung

Prof. Dr. Tobias HartmannZentrum für Molekulare Biologie Heidelberg (ZMBH), Ruprecht-Karls-Universität Heidelberg, Heidelberg
Beginn der ersten Förderung01.09.2003

Programm(e)

2003Humboldt-Forschungsstipendien-Programm

Publikationen (Auswahl)

2007Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.: Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.. In: Neurobiol Dis, 2007, 291-296
2007Amtul Z, Follmer C, Mahboob S, Atta-Ur-Rahman, Mazhar M, Khan KM, Siddiqui RA, Muhammad S, Kazmi SA, Choudhary MI.: Germa-gamma-lactones as novel inhibitors of bacterial urease activity. . In: Biochem Biophys Res Commun., 2007, 457-463
2006Amtul Z, Kausar N, Follmer C, Rozmahel RF, Atta-Ur-Rahman, Kazmi SA, Shekhani MS, Eriksen JL, Khan KM, Choudhary MI. Cysteine based novel noncompetitive inhibitors of urease(s)--distinctive inhibition susceptibility of microbial and plant ureases.. In: Bioorg Med Chem. , 2006, 6737-6744
2006Oksman M, Iivonen H, Hogyes E, Amtul Z, Penke B, Leenders I, Broersen L, Lutjohann D, Hartmann T, Tanila H.: Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice.. In: Neurobiol Dis, 2006, 563--572
2004Amtul Z, Rasheed M, Choudhary MI, Supino R, Khan KM, Atta-Ur-Rahman.: Kinetics of novel competitive inhibitors of urease enzymes by a focused library of oxadiazoles/thiadiazoles and triazoles.. In: Biochem Biophys Res Commun. , 2004, 1053-1063
2003Piper SC, Amtul Z, Galinanes-Garcia L, Howard VG, Ziani-Cherif C, McLendon C, Rochette MJ, Fauq A, Golde TE, Murphy MP.: Peptide-based, irreversible inhibitors of gamma-secretase activity.. In: Biochem Biophys Res Commun. , 2003, 529-533
2002Amtul Z, Lewis PA, Piper S, Crook R, Baker M, Findlay K, Singleton A, Hogg M, Younkin L, Younkin SG, Hardy J, Hutton M, Boeve BF, Tang-Wai D, Golde TE.: A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. . In: Neurobiol Dis. , 2002, 269-273
2002Amtul Z, Rahman AU, Siddiqui RA, Choudhary MI.: Chemistry and mechanism of urease inhibition.. In: Curr Med Chem , 2002, 1323-1348