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Profil
| Derzeitige Stellung | Professor W-3 und Äquivalente |
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| Fachgebiet | Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen |
| Keywords | anthrax toxin, bacterial pathogenesis, bacterial protein toxins, diphtheria toxin, toxin uptake into cells |
Aktuelle Kontaktadresse
| Land | USA |
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| Ort | Boston |
| Universität/Institution | Harvard Medical School |
| Institut/Abteilung | Department of Microbiology and Immunobiology |
Gastgeber*innen während der Förderung
| Prof. Dr. Klaus Aktories | Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Freiburg |
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| Beginn der ersten Förderung | 01.06.2006 |
Programm(e)
| 2005 | Humboldt-Forschungspreis-Programm für Naturwissenschaftler*innen aus den USA |
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Projektbeschreibung der*des Nominierenden
| Prof. R. John Collier has contributed outstanding work in microbiology on the elucidation of mechanisms whereby bacterial protein toxins attack eukaryotic target cells and cause disease of mammalian hosts. He has done pioneering studies on the mode of action and structure of diphtheria toxin and anthrax toxin, which were groundbreaking for understanding of the molecular mechanism of many toxins and allowed design of immunotoxins against cancer and development of novel types of vaccines. During his stay in Germany at the Institute of Experimental and Clinical Pharmacology and Toxicology in Freiburg, he will study the role of cytosolic factors involved in toxin up-take. |
Publikationen (Auswahl)
| 2005 | Bryan A. krantz, Roman A. melnyk, Sen Zhang, Stephen J. Juris, D. Borden Lacy, Zhengyan Wu, Alan Finkelstein, R. John Collier: A Phenylalanine Clamp Catalyzes Protein Translocation Through the Anthrax Toxin Pore. In: Science, 2005, 777 |
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