| 2023 | Aguilar-Sopena, Oscar and Carrasco-Padilla, Carlos and Gomez-Moron, Alvaro and Castro-Sanchez, Patricia and Estaras-Hermosel, Matias and Valvo, Salvatore and Alegre-Gomez, Sergio and Redondo-Munoz, Javier and Torres, Raul and Rodriguez-Perales, Sandra and others: Phosphatases of regenerating liver balance F-actin rearrangements during T cell activation through WD repeat containing protein 1. In: bioRxiv, 2023, 2023--12 |
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| 2022 | Yelland, Tamas and Garcia, Esther and Parry, Charles and Kowalczyk, Dominika and Wojnowska, Marta and Gohlke, Andrea and Zalar, Matja and Cameron, Kenneth and Goodwin, Gillian and Yu, Qing and others: Stabilization of the ras: Pde6d complex is a novel strategy to inhibit ras signaling. In: Journal of Medicinal Chemistry, 65, 2022, 1898--1914 |
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| 2021 | ElMaghloob, Yasmin and Sot, Bego{\~n}a and McIlwraith, Michael J and Garcia, Esther and Yelland, Tamas and Ismail, Shehab: ARL3 activation requires the co-GEF BART and effector-mediated turnover. In: Elife, 10, 2021, e64624 |
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| 2021 | Powell, Laura and Samarakoon, Youhani H and Ismail, Shehab and Sayer, John A: ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses. In: Small GTPases, 12, 2021, 167--176 |
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| 2021 | Nacke, Marisa and Sandilands, Emma and Nikolatou, Konstantina and Rom{\'a}n-Fern{\'a}ndez, {\'A}lvaro and Mason, Susan and Patel, Rachana and Lilla, Sergio and Yelland, Tamas and Galbraith, Laura CA and Freckmann, Eva C and others: An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. In: Nature Communications, 12, 2021, 1623 |
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| 2021 | Le, Anh Hoang and Yelland, Tamas and Paul, Nikki R and Fort, Loic and Nikolaou, Savvas and Ismail, Shehab and Machesky, Laura M: CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation. In: The Journal of Cell Biology, 220, 2021, |
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| 2021 | Rabas, Nicolas and Palmer, Sarah and Mitchell, Louise and Ismail, Shehab and Gohlke, Andrea and Riley, Joel S and Tait, Stephen WG and Gammage, Payam and Soares, Leandro Lemgruber and Macpherson, Iain R and others: PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness. In: The Journal of cell biology, 220, 2021, |
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| 2021 | Yelland, Tamas and Garcia, Esther and Samarakoon, Youhani and Ismail, Shehab: The structural and biochemical characterization of UNC119B cargo binding and release mechanisms. In: Biochemistry, 60, 2021, 1952--1963 |
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| 2020 | Mansour, Manar and Ismail, Shehab and Abou-Aisha, Khaled: Bacterial delivery of the anti-tumor azurin-like protein Laz to glioblastoma cells. In: AMB Express, 10, 2020, 59 |
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| 2020 | Le, Anh Hoang and Yelland, Tamas and Paul, Nikki R and Fort, Loic and Nikolaou, Savvas and Ismail, Shehab and Machesky, Laura M: CYRI-A regulates macropinocytic cup maturation and mediates integrin uptake, limiting invasive migration. In: bioRxiv, 2020, 2020--12 |
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| 2020 | Garcia, Esther and Ismail, Shehab: Spatiotemporal regulation of signaling: focus on T cell activation and the immunological synapse. In: International journal of molecular sciences, 21, 2020, 3283 |
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| 2019 | Hernandez-Fernaud, Juan R and Ruengeler, Elena and Neilson, Lisa J and Ismail, Shehab and McNeish, Iain and Atkinson, Samuel and Lilla, Sergio and Santi, Alice and Valenzuela, Stella M and Blyth, Karen and others: Abstract AP18: PRO-INVASIVE TUMOUR-STROMA INTERACTIONS: ROLE OF THE SECRETED OXIDOREDUCTASE CLIC3. In: Clinical Cancer Research, 25, 2019, AP18--AP18 |
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| 2019 | Kugeratski, Fernanda G and Atkinson, Samuel J and Neilson, Lisa J and Lilla, Sergio and Knight, John RP and Serneels, Jens and Juin, Amelie and Ismail, Shehab and Bryant, David M and Markert, Elke K and others: Hypoxic cancer--associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. In: Science signaling, 12, 2019, eaan8247 |
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| 2019 | Hernandez-Fernaud, Juan R and Ruengeler, Elena and Neilson, Lisa J and Ismail, Shehab and McNeish, Iain and Atkinson, Samuel and Lilla, Sergio and Santi, Alice and Valenzuela, Stella M and Blyth, Karen and others: PRO-INVASIVE TUMOUR-STROMA INTERACTIONS: ROLE OF THE SECRETED OXIDOREDUCTASE CLIC3. In: Clinical Cancer Research, 25, 2019, 136--136 |
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| 2019 | Nacke, Marisa and Sandilands, Emma and Nikolatou, Konstantina and Rom{\'a}n-Fern{\'a}ndez, {\'A}lvaro and Mason, Susan and Patel, Rachana and Lilla, Sergio and Yelland, Tamas and Galbraith, Laura and McGarry, Lynn and others: Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis. In: bioRxiv, 2019, 851410 |
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| 2019 | Amato, Clelia and Thomason, Peter A and Davidson, Andrew J and Swaminathan, Karthic and Ismail, Shehab and Machesky, Laura M and Insall, Robert H: WASP restricts active Rac to maintain cells’ front-rear polarization. In: Current Biology, 29, 2019, 4169--4182 |
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| 2018 | Alkanderi, Sumaya and Molinari, Elisa and Shaheen, Ranad and Elmaghloob, Yasmin and Stephen, Louise A and Sammut, Veronica and Ramsbottom, Simon A and Srivastava, Shalabh and Cairns, George and Edwards, Noel and others: ARL3 mutations cause Joubert syndrome by disrupting ciliary protein composition. In: The American Journal of Human Genetics, 103, 2018, 612--620 |
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| 2018 | Fort, Loic and Batista, Jose and Thomason, Peter A and Spence, Heather J and Whitelaw, Jamie A and Tweedy, Luke and Greaves, Jennifer and Martin, Kirsty J and Anderson, Kurt I and Brown, Peter and others: CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1. In: Nature cell biology, 20, 2018, 1159 |
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| 2018 | Fort, Loic and Batista, Jos{\'e} Miguel and Thomason, Peter A and Spence, Heather J and Whitelaw, Jamie A and Tweedy, Luke and Greaves, Jennifer and Martin, Kirsty J and Anderson, Kurt I and Brown, Peter and others: Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. In: Nature cell biology, 20, 2018, 1159--1171 |
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| 2018 | Stephen, Louise A and ElMaghloob, Yasmin and McIlwraith, Michael J and Yelland, Tamas and Sanchez, Patricia Castro and Roda-Navarro, Pedro and Ismail, Shehab: The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK. In: Developmental cell, 47, 2018, 122--132 |
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| 2017 | Ismail, Shehab: A GDI/GDF-like system for sorting and shuttling ciliary proteins. In: Small GTPases, 8, 2017, 208--211 |
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| 2017 | Mart{\'\i}n-Gago, Pablo and Fansa, Eyad K and Klein, Christian H and Murarka, Sandip and Janning, Petra and Schürmann, Marc and Metz, Malte and Ismail, Shehab and Schultz-Fademrecht, Carsten and Baumann, Matthias and others: A PDE6$\delta$-KRas inhibitor chemotype with up to seven H-bonds and picomolar affinity that prevents efficient inhibitor release by Arl2. In: Angewandte Chemie, 129, 2017, 2463--2468 |
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| 2017 | Gray, Christopher H and Konczal, Jennifer and Mezna, Mokdad and Ismail, Shehab and Bower, Justin and Drysdale, Martin: A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. In: Protein Expression and Purification, 132, 2017, 75--84 |
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| 2017 | Fort, L and Batista, J and Thomason, P and Spence, H and Greaves, J and Martin, K and Anderson, K and Brown, P and Lilla, S and Nielson, M and others: CYRIPS (Fam49) proteins are local inhibitors of Rac1 and Scar/WAVE induced lamellipodia.. In: Molecular Biology Of The Cell, 28, 2017, |
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| 2017 | Murarka, Sandip and Mart{\'\i}n-Gago, Pablo and Schultz-Fademrecht, Carsten and Al Saabi, Alaa and Baumann, Matthias and Fansa, Eyad K and Ismail, Shehab and Nussbaumer, Peter and Wittinghofer, Alfred and Waldmann, Herbert: Development of pyridazinone chemotypes targeting the PDE$\delta$ prenyl binding site. In: Chemistry--A European Journal, 23, 2017, 6083--6093 |
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| 2017 | Stephen, Louise A and Elmaghloob, Yasmin and Ismail, Shehab: Maintaining protein composition in cilia. In: Biological Chemistry, 399, 2017, 1--11 |
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| 2017 | Hernandez-Fernaud, Juan R and Ruengeler, Elena and Casazza, Andrea and Neilson, Lisa J and Pulleine, Ellie and Santi, Alice and Ismail, Shehab and Lilla, Sergio and Dhayade, Sandeep and MacPherson, Iain R and others: Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. In: Nature communications, 8, 2017, 14206 |
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| 2017 | Reid, Steven E and Kay, Emily J and Neilson, Lisa J and Henze, Anne-Theres and Serneels, Jens and McGhee, Ewan J and Dhayade, Sandeep and Nixon, Colin and Mackey, John BG and Santi, Alice and others: Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. In: The EMBO journal, 36, 2017, 2373--2389 |
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| 2016 | Mansour, Manar and Ismail, Shehab and Abou-Aisha, Khaled: Development of Salmonella typhimurium VNP20009 as a Delivery Vector of the Novel Neisserial Anti-tumor Protein Laz. HUMAN GENE THERAPY. 2016. A8--A8 |
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| 2016 | Papke, Björn and Murarka, Sandip and Vogel, Holger A and Mart{\'\i}n-Gago, Pablo and Kovacevic, Marija and Truxius, Dina C and Fansa, Eyad K and Ismail, Shehab and Zimmermann, Gunther and Heinelt, Kaatje and others: Identification of pyrazolopyridazinones as PDE$\delta$ inhibitors. In: Nature communications, 7, 2016, 11360 |
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| 2016 | Fansa, Eyad Kalawy and Kösling, Stefanie Kristine and Zent, Eldar and Wittinghofer, Alfred and Ismail, Shehab: PDE6$\delta$-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. In: Nature communications, 7, 2016, 11366 |
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| 2016 | Stephen, Louise A and Ismail, Shehab: Shuttling and sorting lipid-modified cargo into the cilia. In: Biochemical Society Transactions, 44, 2016, 1273--1280 |
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| 2016 | Amato, C and Davidson, AJ and Thomason, PA and Barratt, S and Ismail, S and Insall, RH: WASP maintains cell polarity by preventing aberrant accumulation of active Rac.. MOLECULAR BIOLOGY OF THE CELL. 2016. |
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| 2015 | Kapoor, Shobhna and Fansa, Eyad K and Möbitz, Simone and Ismail, Shehab A and Winter, Roland and Wittinghofer, Alfred and Weise, Katrin: Effect of the N-terminal helix and nucleotide loading on the membrane and effector binding of Arl2/3. In: Biophysical Journal, 109, 2015, 1619--1629 |
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| 2015 | Kapoor, Shobhna and Möbitz, Simone and Ismail, Shehab A and Fansa, Eyad Kalawy and Wittinghofer, Alfred and Winter, Roland and Weise, Katrin: The Difference in Arl2 and Arl3 Membrane Binding and Localization. In: Biophysical Journal, 108, 2015, 381a |
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| 2015 | Fansa, Eyad Kalawy and O'Reilly, Nicola J and Ismail, Shehab and Wittinghofer, Alfred: The N-and C-terminal ends of RPGR can bind to PDE 6$\delta$. In: EMBO reports, 16, 2015, 1583--1585 |
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| 2014 | Bravo-Rodriguez, Kenny and Ismail-Ali, Ahmed F and Klopries, Stephan and Kushnir, Susanna and Ismail, Shehab and Fansa, Eyad K and Wittinghofer, Alfred and Schulz, Frank and Sanchez-Garcia, Elsa: Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives. In: ChemBioChem, 15, 2014, 1991--1997 |
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| 2014 | Zimmermann, Gunther and Schultz-Fademrecht, Carsten and Küchler, Philipp and Murarka, Sandip and Ismail, Shehab and Triola, Gemma and Nussbaumer, Peter and Wittinghofer, Alfred and Waldmann, Herbert: Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDE$\delta$ prenyl binding site. In: Journal of medicinal chemistry, 57, 2014, 5435--5448 |
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| 2014 | Suladze, S and Ismail, S and Winter, R: Thermodynamic, dynamic and solvational properties of PDE$\delta$ binding to farnesylated cystein: a model study for uncovering the molecular mechanism of PDE$\delta$ interaction with prenylated proteins. In: The Journal of Physical Chemistry B, 118, 2014, 966--975 |
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| 2013 | Zimmermann, Gunther and Papke, Björn and Ismail, Shehab and Vartak, Nachiket and Chandra, Anchal and Hoffmann, Maike and Hahn, Stephan A and Triola, Gemma and Wittinghofer, Alfred and Bastiaens, Philippe IH and others: Small molecule inhibition of the KRAS--PDE$\delta$ interaction impairs oncogenic KRAS signalling. In: Nature, 497, 2013, 638--642 |
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| 2013 | Wätzlich, Denise and Vetter, Ingrid and Gotthardt, Katja and Miertzschke, Mandy and Chen, Yong-Xiang and Wittinghofer, Alfred and Ismail, Shehab: The interplay between RPGR, PDE$\delta$ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. In: EMBO reports, 14, 2013, 465--472 |
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| 2012 | Ismail, S and Chen, YC and Rusinnova, AR and Chandra, AC and Bierbaum, MB and Gremer, LG and Triola, GT and Waldmann, HW and Batiaens, PB and Winttinghofer, AW: Arl3 regulates a transport system for farnesylated cargo. In: Cilia, 1, 2012, 1--1 |
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| 2012 | Ismail, Shehab A and Chen, Yong-Xiang and Miertzschke, Mandy and Vetter, Ingrid R and Koerner, Carolin and Wittinghofer, Alfred: Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. In: The EMBO journal, 31, 2012, 4085--4094 |
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| 2012 | Chandra, Anchal and Grecco, Hern{\'a}n E and Pisupati, Venkat and Perera, David and Cassidy, Liam and Skoulidis, Ferdinandos and Ismail, Shehab A and Hedberg, Christian and Hanzal-Bayer, Michael and Venkitaraman, Ashok R and others: The GDI-like solubilizing factor PDE$\delta$ sustains the spatial organization and signalling of Ras family proteins. In: Nature cell biology, 14, 2012, 148--158 |
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| 2011 | Ismail, Shehab A and Chen, Yong-Xiang and Rusinova, Alexandra and Chandra, Anchal and Bierbaum, Martin and Gremer, Lothar and Triola, Gemma and Waldmann, Herbert and Bastiaens, Philippe IH and Wittinghofer, Alfred: Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. In: Nature chemical biology, 7, 2011, 942--949 |
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| 2010 | Ismail, Shehab A and Vetter, Ingrid R and Sot, Begona and Wittinghofer, Alfred: The Structure of an Arf-ArfGAP Complex Reveals a Ca 2+ Regulatory Mechanism (vol 141, pg 812, 2010). In: Cell, 143, 2010, 1190--1190 |
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| 2008 | Veltel, Stefan and Kravchenko, Aleksandra and Ismail, Shehab and Wittinghofer, Alfred: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. In: Febs Letters, 582, 2008, 2501--2507 |
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| 2005 | Ismail, Shehab Amr and Park, HW: Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase. In: Acta Crystallographica Section D: Biological Crystallography, 61, 2005, 1508--1513 |
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| 2004 | Fasching, C and Feng, X and Ferenczi, S and Ferguson, DJP and Forns, N and Foster, JW and Frigimelica, E and Frost, LS and Fuchs, G and Funayama, T and others: Edwards, DH, 1237 Ehrlich, SD, 439 Eisenreich, W., 223 Engel, A., 647 Erill, I., 212. In: Molecular Microbiology, 54, 2004, 1467--1470 |
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| 2004 | Aziz, Ramy K and Ismail, Shehab A and Park, Hee-Won and Kotb, Malak: Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes. In: Molecular microbiology, 54, 2004, 184--197 |
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