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Profil
| Derzeitige Stellung | Professor W-3 und Äquivalente |
|---|---|
| Fachgebiet | Molekulare und zelluläre Neurologie und Neuropathologie |
| Keywords | Core Body Temperature Homeostasis, Hypothalamus, Ion Channels, Calcium Imaging, Temperature Sensitivity |
Aktuelle Kontaktadresse
| Land | Deutschland |
|---|---|
| Ort | Heidelberg |
| Universität/Institution | Ruprecht-Karls-Universität Heidelberg |
| Institut/Abteilung | Pharmakologisches Institut, Abteilung Molekulare Pharmakologie |
| Website | www.medizinische-fakultaet-hd.uni-heidelberg.de/Siemens.102639.0.html |
Gastgeber*innen während der Förderung
| Prof. Dr. Gary Lewin | Max-Delbrück-Centrum für Molekulare Medizin (MDC), Berlin |
|---|---|
| Prof. Dr. Rohini Kuner | Pharmakologisches Institut, Abteilung Molekulare Pharmakologie, Ruprecht-Karls-Universität Heidelberg, Heidelberg |
| Beginn der ersten Förderung | 01.01.2009 |
Programm(e)
| 2008 | Sofja Kovalevskaja-Preis-Programm |
|---|
Projektbeschreibung der*des Nominierenden
| Mammals including humans are homeothermic animals, which means that they maintain a very constant core body temperature around 37°C. It has long been known that a region of the brain called the hypothalamus contains neurons that sense tiny changes in temperature around the set-point of 37°C. The hypothalamus is also involved in controlling body temperature. It is increasingly appreciated that temperature sensors in the body may convey input to the hypothalamus to help this control center to maintian the correct core temperature. In essence one can view the hypothalamus as the central thermostat of the brain. Despite this knowledge there is remarkably little known about the molecular mechanisms by which neurons actually sense cooling and warming of the body. Dr. Siemens has already made key contributions to characterizing a thermosensitive ion channel called TRPM8 that is specifically activated by cooling. He now wishes to elucidate the contribution of this temperature sensor in helping the central thermostat to maintain normal core temperature. The discovery of molecules that are required for the maintenance of body temperature will be of fundamental importance as this is an unchartered frontier in molecular sensing. |
Publikationen (Auswahl)
| 2014 | Prof. Dr. Jan-Erik Siemens, Nevena Milenkovic, Wen-Jie Zhao, Jan Walcher, Tobias Albert, Gary Lewin, James Poulet: A somatosensory circuit for cooling perception in mice. In: Nature Neuroscience, 2014, 1560-1566 |
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| 2014 | Prof. Dr. Jan-Erik Siemens, Christian Hanack, Mirko Moroni, Wanessa C. Lima, Hagen Wende, Marieluise Kirchner, Lisa Adelfinger, Katrin Schrenk-Siemens, Anke Tappe-Theodor, Christiane Wetzel, P. Henning Kuich, Martin Gassmann, Dennis Roggenkamp, Bernhard Bettler, Gary R. Lewin, Matthias Selbach: GABA Blocks Pathological but Not Acute TRPV1 Pain Signals. In: Cell, 2014, 759-770 |
| 2014 | Prof. Dr. Jan-Erik Siemens, Christina Hanack: Modulation of TRP Ion Channels by Venomous Toxins. In: Bernd Nilius, Veit Flockerzi, Mammalian Transient Receptor Potential (TRP) Cation Channels-Handbook of Experimental Pharmacology, Vol.223. Springer-Verlag, 2014. 1119-1142 |
| 2014 | Prof. Dr. Jan-Erik Siemens, Katrin Schrenk-Siemens, Hagen Wende, Vincenzo Prato, Kun Song, Charlotte Rostock, Alexander Loewer, Jochen Utikal, Gary R. Lewin, Stefan G. Lechner: PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. In: Nature Neuroscience, 2014, 759-770 |
| 2012 | Prof. Dr. Jan-Erik Siemens, Katja Kapp, Hans-Ulrich Häring, Reiner Lammers: Proteolytic processing of the protein tyrosine phosphatase alpha extracellular domain is mediated by ADAM17/TACE. In: Eur J Cell Biol, 2012, 687-693 |
| 2011 | Prof. Dr. Jan-Erik Siemens, Dr. Stefan Lechner: Sensory transduction, the gateway to perception: mechanisms and pathology. In: Embo Reports, 2011, 292-295 |
| 2010 | Prof. Dr. Jan-Erik Siemens, Christopher J. Bohlen, Avi Priel, Sharleen Zhou, David King, David Julius: A Biavalent Tarantula Toxin Reveals a Unique Role for the Outer Pore Domain in TRP Channel Gating. In: Cell, 2010, 834-845 |