Priv. Doz. Dr. Nicholas James Bradshaw

Profil

Derzeitige StellungProfessor W-2 und Äquivalente
FachgebietMolekulare und zelluläre Neurologie und Neuropathologie,Biologische Psychiatrie
Keywordsprotein-protein interactions, protein aggregation, schizophrenia, psychiatric illness, neurodevelopment
Auszeichnungen

2020: Nominated for citizenship of the Republic of Croatia by the Minister of Science & Education, on the basis of scientific and teaching activity

2011: Alexander von Humboldt research fellowship for postdoctoral researchers

2005: Medical Resarch Council (UK) funded doctoral scholarship

Aktuelle Kontaktadresse

LandKroatien
OrtRijeka
Universität/InstitutionUniversity of Rijeka
Institut/AbteilungDepartment of Biotechnology
Websitebradshawlab.uniri.hr

Gastgeber*innen während der Förderung

Prof. Dr. Carsten KorthInstitut für Neuropathologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf
Priv. Doz. Dr. Nicholas James BradshawDepartment of Biotechnology, University of Rijeka, Rijeka
Priv. Doz. Dr. Oliver H. WeiergräberISB-3: Strukturbiochemie, Forschungszentrum Jülich GmbH, Jülich
Beginn der ersten Förderung01.10.2011

Programm(e)

2011Humboldt-Forschungsstipendien-Programm für Postdocs

Publikationen (Auswahl)

2024Beti Zaharija & Nicholas Bradshaw: Aggregation of Disrupted in Schizophrenia 1 arises from a central region of the protein. In: Progress in Neuropsychopharmacology & Biological Psychiatry, 130, 2024, 110923
2024Maja Juković, Ivana Ratkaj, Daniela Kalafatovic & Nicholas J. Bradshaw: Amyloids, amorphous aggregates and assemblies of peptides – Assessing aggregation. In: Biophysical Chemistry, 308, 2024, 107202
2024Bobana Samardžija, Milan Petrovič, Beti Zaharija, Marta Medija, Ana Meštrovć, Nicholas J. Bradshaw, Ana Filošević Vujnović & Rozi Andretić Waldowski: Transgenic Drosophila melanogaster Carrying a Human Full-Length DISC1 Construct (UAS-hflDISC1) Showing Effects on Social Interaction Networks. In: Current Issues in Molecular Biology, 46, 2024, 8526-8549
2023Thays Calista Santiago, Larissa Parra, João V. Nani, Thiago M. Fidalgo, Nicholas J. Bradshaw & Mirian A. F. Hayashi: Angiotensin-converting enzymes as druggable features of psychiatric and neurodegenerative disorders. In: Journal of Neurochemistry, 166, 2023, 138-155
2023Bobana Samardžija, Maja Juković, Beti Zaharija, Éva Renner, Miklós Palkovits & Nicholas J. Bradshaw: Co-Aggregation and Parallel Aggregation of Specific Proteins in Major Mental Illness. In: Cells, 12, 2023, 1848
2023Beti Zaharija & Nicholas Bradshaw: Mapping the Domain Structure and Aggregation Propensity of Proteins Using a Gateway Plasmid Vector System. In: Andrzej Stanisław Cieplak, Protein Aggregation: Methods and Protocols. Springer Nature, 2023. 649-677
2022Beti Zaharija, Maja Odorčić, Anja Hart, Bobana Samardžija, Rita Marreiros, Ingrid Prikulis, Maja Juković Thomas M. Hyde, Joel E. Kleinman, Carsten Korth and Nicholas J. Bradshaw: TRIOBP-1 protein aggregation exists in both major depressive disorder and schizophrenia, and can occur through two distinct regions of the protein. In: International Journal of Molecular Sciences, 23, 2022, 11048
2020Nicholas J. Bradshaw, Svenja V. Trossbach, Sabrina K?ber, Susanne Walter, Ingrid Prikulis, Sascha Weggen and Carsten Korth: Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex. In: Schiz. Res., 215, 2020, 506-513
2017Antony S.K. Yerabham, Philippe J. Mas, Christina Decker, Dinesh C. Soares, Oliver H. Weiergräber, Luitgard Nagel-Steger, Dieter Willbold, Darren J. Hart, Nicholas J. Bradshaw, Carsten Korth: A structural organization for Disrupted in Schizophrenia 1, identified by high-throughput screening, reveals distinctly folded regions which are bisected by mental illness-related mutations . In: Journal of Biological Chemistry, 2017, 6468-6477
2017Nina Sarah Gowert, Irena Krüger, Meike Klier, Lili Donner, Friederike Kipkeew, Michael Gliem, Nicholas J. Bradshaw, David Lutz, Sabrina Köber, Harald Langer, Sebastien Jander, Kerstin Jurk, Michael Frotscher, Carsten Korth, Hans H. Bock, Margitta Elvers: Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. In: Cellular Signalling, 2017, 210-221
2017Nicholas J. Bradshaw, Liisa Ukkola-Vuoti, Maiju Pankakoski, Amanda B. Zheutlin, Alfredo Ortega-Alonso, Minna Torniainen-Holm, Vishal Sinha, Sebastian Therman, Tiina Paunio, Jaana Suvisaari, Jouko Lonnqvist, Tyrone D. Cannon, Jari Haukka and William Hennah: The NDE1 genomic locus affects treatment of psychiatric illness through gene expression changes related to MicroRNA-484. In: Open Biol., 7, 2017, 170153
2014Nicholas J. Bradshaw, Verian Bader, Ingrid Prikulis, Angelika Lueking, Stefan Müllner, Carsten Korth: Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia. In: PLOS One, 2014, e111196
2013Nicholas J. Bradshaw, William Hennah, Dinesh C. Soares: NDE1 and NDEL1: twin neurodevelopmental proteins with similar ‘nature’ but different ‘nurture’. In: Biomolecular Concepts, 2013, 447-464
2013Antony S. K. Yerabham, Oliver H. Weiergräber, Nicholas J. Bradshaw, Carsten Korth: Revisiting Disrupted-in-Schizophrenia 1 as a scaffold protein. In: Biological Chemistry, 2013, 1425-1437
2012Verian Bader, Liisa Tomppo, Svenja V. Trossbach, Nicholas J. Bradshaw, Ingrid Prikulis, S. Rutger Leliveld, Chi-Ying Lin, Koko Ishizuka, Akira Sawa, Adriana Ramos, Isaac Rosa, Ángel Garcià, Jesús R. Requena, Maria Hipolito, Narayan Rai, Evaristus Nwulia, Uwe Henning, Stefano Ferrea, Christian Luckhaus, Jesper Ekelund, Juha Veijola, Marjo-Riitta Järvelin, William Hennah, Carsten Korth: Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. In: Human Molecular Genetics, 2012, 4406-4418