| 2018 | Fischer IP, Irmler M, Meyer CW, Sachs SJ, Neff F, Hrab? de Angelis M, Beckers J, Tschöp MH, Hofmann SM, Ussar S: A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue. In: Int J Obes (Lond), 2018, 507-517 |
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| 2018 | Müller TD, Clemmensen C, Finan B, DiMarchi RD, Tschöp MH: Anti-Obesity Therapy: from Rainbow Pills to Polyagonists. In: Pharmacol Rev (review), 2018, 712-746 |
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| 2018 | Brandt SJ, Kleinert M, Tschöp MH, Müller TD. Are peptide conjugates the golden therapy against obesity?. In: J Endocrinol, 2018, R109-R119 |
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| 2018 | Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, Jastroch M, Schneider S, de Mateo S, Cervantes M, Abbondante S, Tognini P, Orozco-Solis R, Kinouchi K, Wang C, Swerdloff R, Nadeef S, Masri S, Magistretti P, Orlando V, Borrelli E, Uhlenhaut NH, Baldi P, Adamski J, Tschöp MH, Eckel-Mahan K, Sassone-Corsi P.: Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks. In: Cell , 2018, 1571-1585.e11 |
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| 2018 | Pfuhlmann K, Schriever SC, Legutko B, Baumann P, Harrison L, Kabra DG, Baumgart EV, Tschöp MH, Garcia-Caceres C, Pfluger PT: Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice. In: Neuroinflammation, 2018, 35 |
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| 2018 | Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT: Celastrol Induced Weight Loss is Driven by Hypophagia and Independent From UCP1. In: Diabetes , 2018, 2456-2465 |
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| 2018 | Clemmensen C, Jall S, Kleinert M, Quarta C, Gruber T, Reber J, Stephan Sachs S, Fischer K, Feuchtinger A, Karlas A, Simonds SE, Grandl G, Loher D, Sanchez-Quant E, Keipert S, Jastroch M, Hofmann SM, Emmani BM Nascimento EBM, Schrauwen P, Ntziachristos V, Cowley MA, Finan B, Müller TD, Tschöp MH Cordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes. In: Nature Communications, 2018, 4975 |
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| 2018 | Poher AL, Tschöp MH, Müller TD: Ghrelin regulation of glucose metabolism. In: Peptides, 2018, 236-242 |
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| 2018 | Brandt SJ, Götz A, Tschöp MH, Müller TD: Gut hormone polyagonists for the treatment of type 2 diabetes. In: Peptides, 2018, 190-201 |
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| 2018 | Suwandhi L, Hausmann S, Braun A, Gruber T, Heinzmann SS, Gálvez EJC, Buck A, Legutko B, Israel A, Feuchtinger A, Haythorne E, Staiger H, Heni M, Häring HU, Schmitt-Kopplin P, Walch A, Cáceres CG, Tschöp MH, Rutter GA, Strowig T, Elsner M, Ussar S: Strowig T, Elsner M, Ussar S. Chronic . In: Mol Metab, 2018, 191-202 |
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| 2018 | Kleinert M, Kotzbeck P, Altendorfer-Kroath T, Birngruber T, Tschöp MH, Clemmensen C: Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice. In: Mol Metab, 2018, 77-82 |
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| 2017 | Kälin S, Becker M, Ott VB, Serr I, Hosp F, Mollah MMH, Keipert S, Lamp D, Rohner-Jeanrenaud F, Flynn VK, Scherm MG, Nascimento LFR, Gerlach K, Popp V, Dietzen S, Bopp T, Krishnamurthy P, Kaplan MH, Serrano M, Woods SC, Tripal P, Palmisano R, Jastroch M, Blüher M, Wolfrum C, Weigmann B, Ziegler AG, Mann M, Tschöp MH, Daniel C: A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. In: Cell Metab , 2017, 475-492.e7 |
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| 2017 | Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C: Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. In: Nat Med, 2017, 623-630 |
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| 2017 | Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX: Dietary sugars, not lipids, drive hypothalamic inflammation. In: Mol Metab, 2017, 897-908 |
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| 2017 | Gao Y, Layritz C, Legutko B, Eichmann TO, Laperrousaz E, Moullé VS, Cruciani-Guglielmacci C, Magnan C, Luquet S, Woods SC, Eckel RH, Yi CX, Garcia-Caceres C, Tschöp MH: Disruption of Lipid Uptake in Astroglia Exacerbates Diet Induced Obesity. In: Diabetes, 2017, 2555-2563 |
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| 2017 | Pfuhlmann K, Pfluger PT, Schriever SC, Müller TD, Tschöp MH, Stemmer K. Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice. In: PLoS One, 2017, e0183488 |
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| 2017 | Kleinert M, Clemmensen C, Stemmer K, Müller TD, DiMarchi RD, Tschöp MH: Emerging Poly-Agonists for Obesity and Type 2 Diabetes. In: Obesity (Silver Spring), 2017, 1647-1649 |
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| 2017 | Varela L, Suyama S, Huang Y, Shanabrough M, Tschöp MH, Gao XB, Giordano FJ, Horvath TL: Endothelial HIF-1? Enables Hypothalamic Glucose Uptake to Drive POMC Neurons. In: Diabetes, 2017, 1511-1520 |
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| 2017 | Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN.; WTCCC3., Heid IM, Winkler TW; GIANT., Grant SF; EGG., Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group.; Childrens Hospital of Philadelphia/Price Foundation., Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. In: Mol Psychiatry, 2017, 192-201 |
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| 2017 | Sánchez-Garrido MA, Brandt SJ, Clemmensen C, Müller TD, DiMarchi RD, Tschöp MH: GLP-1/glucagon receptor co-agonism for treatment of obesity. In: Diabetologia, 2017, 1851-1861 |
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| 2017 | Keipert S, Kutschke M, Ost M, Schwarzmayr T, van Schothorst EM, Lamp D, Brachthäuser L, Hamp I, Mazibuko SE, Hartwig S, Lehr S, Graf E, Plettenburg O, Neff F, Tschöp MH, Jastroch M: Long-Term Cold Adaptation Does Not Require FGF21 or UCP1. In: Cell Metab, 2017, 437-446.e5 |
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| 2017 | Quarta C, Clemmensen C, Zhu Z, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Yang B, Vettorazzi S, Hofmann S, Bakhti M, Ponce MB, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Tuckermann J, Hrabe de Angelis M, Cota D, Latz E, Sandoval D, Randy Seeley RJ, Müller TD, Yang B, DiMarchi R, Finan B & Tschöp MH: Molecular Integration of Incretin and Glucocorticoid Reverses Metabolic Inflammation and Obesity. In: Cell Metab, 2017, 620-632.e6 |
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| 2017 | Jall S, Sachs S, Clemmensen C, Finan B, Neff F, DiMarchi RD, Tschöp MH, Müller TD, Hofmann SM: Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice. In: Mol Metab, 2017, 440-446 |
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| 2017 | Yi CX, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, Layritz C, García-Cáceres C, Bielohuby M, Bidlingmaier M, Woods SC, Ghanem A, Conzelmann KK, Stern JE, Jastroch M, Tschöp MH: TNF? drives mitochondrial stress in POMC neurons in obesity. In: Nat Commun, 2017, 15143 |
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| 2017 | Colldén G, Tschöp MH, Müller TD: Therapeutic Potential of Targeting the Ghrelin Pathway. In: Int J Mol Sci (review) , 2017, |
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| 2016 | García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. In: Cell , 2016, 867-880 |
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| 2016 | Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrab? de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. In: Cell, 2016, 843-857 |
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| 2015 | Müller TD, Nogueiras R, (...), Tschöp MH: Ghrelin. In: Mol Metab, 2015, 437-460 |
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| 2015 | Kälin S, Heppner FL, Bechmann I, Prinz M, Tschöp MH, Yi CX: Hypothalamic innate immune reaction in obesity. In: Nat Rev Endocrinol, 2015, 339-351 |
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| 168 | Clemmensen C, Müller TD, Woods SC, Berthoud HR, Seeley RJ, Tschöp MH: Gut-Brain Cross-Talk in Metabolic Control. In: Cell (review), 168, 758-774 |
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| 24 | Tschöp MH, Finan B, Clemmensen C, Gelfanov V, Perez-Tilve D, Müller TD, DiMarchi RD: Unimolecular Polypharmacy for Treatment of Diabetes and Obesity. In: Cell Metab. , 24, 51-62 |
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| 22 | Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrab? de Angelis M, Walch A, Rollmann SM, Aronow BJ, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. In: Cell Metab. , 22, 838-850 |
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| 22 | Finan B, Müller TD, Clemmensen C, Perez-Tilve D, DiMarchi RD, Tschöp MH: Reappraisal of GIP Pharmacology for Metabolic Diseases. In: Trends Mol Med, 22, 359-376 |
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| Becker M*, Kälin S*, Salb VK, Ott V, Kälin RE, Markus Hippich M, Scherm MG, Nascimento L, Serr I, Hosp F, Nikolaev A, Mohebiany A, Krüger M, Legutko B, Pfaffl M, Haase B, Yi CX, Dietzen S, Bopp T, Woods SC, Wolfrum C, Waisman A, Weigmann B, Mann M, Tschöp MH, Daniel C; (*both authors contributed equally to this work): Regulatory T cells control hypothalamic innate immune responsiveness to high calorie environments. In: Cell Metab (in revision), , |
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