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Profil
| Derzeitige Stellung | Professor W-1 und Äquivalente |
|---|---|
| Fachgebiet | Molekulare Biologie und Physiologie von Nerven- und Gliazellen |
| Keywords | Animal and Cell models, Neurosciences, Therapeutic strategies, Neuroprotection, Neurodegenerative diseases |
| Auszeichnungen | 2023: Outstanding Poster Presentation & Best Visual Presentation Award. Chan Zuckerberg Initiative. Neurodegeneration Challenge Network (NDCN) Annual Meeting 2023. 2016: Alexander von-Humboldt Research Fellowship for Postdoctoral Researchers (24-month). Germany. 2012: Travel award from the French Society of Cellular and Gene Therapy for the participation to the Summer School 2012 « Gene Therapy and Regenerative Medicine ». University of Cologne, Germany. 2011: 3-year full scholarship by French Ministry of Education and Research (MESR) for Ph.D. studies in Life and Health Sciences. University of Paris-Sud, Orsay, France. |
Aktuelle Kontaktadresse
| Land | USA |
|---|---|
| Ort | Chicago |
| Universität/Institution | Northwestern University |
| Institut/Abteilung | School of Medicine Department of Neurology |
Gastgeber*innen während der Förderung
| Prof. Dr. Tiago Fleming Outeiro | University Medical Center Göttingen, Georg-August-Universität Göttingen, Göttingen |
|---|---|
| Prof. Dr. Gudrun Rappold | Institut für Humangenetik, Ruprecht-Karls-Universität Heidelberg, Heidelberg |
| Beginn der ersten Förderung | 01.04.2016 |
Programm(e)
| 2015 | Humboldt-Forschungsstipendien-Programm für Postdocs |
|---|
Publikationen (Auswahl)
| 2022 | Heinl ES, Lorenz S, Schmidt B, Nasser M Laqtom N, Mazzulli JR, Francelle L, Yu TW, Greenberg B, Storch S, Tegtmeier I, Othmen H, Maurer K, Steinfurth M, Witzgall R, Milenkovic V, Wetzel CH, Reichold M: CLN7/MFSD8 may be an important factor for SARS-CoV-2 cell entry. In: iScience, 2022, |
|---|---|
| 2022 | Francelle L, Mazzulli JR: Neuroinflammation in Gaucher disease, neuronal ceroid lipofuscinosis, and commonalities with Parkinson's disease. In: Brain Research, 2022, |
| 2022 | Iva Stojkovska, Willayat Y Wani, Friederike Zunke, Nandkishore R Belur, Egor A Pavlenko, Nkatha Mwenda, Karan Sharma, Laetitia Francelle, Joseph R Mazzulli Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking. In: Neuron, 2022, |
| 2020 | Laetitia Francelle, Tiago Outeiro, Gudrun A Rappold: Inhibition of HDAC6 activity protects dopaminergic neurons from alpha-synuclein toxicity. In: Scientific Reports, 2020, |
| 2018 | Laurie Galvan*, Laetitia Francelle*, Marie-Claude Gaillard, Lucie de Longprez, Maria-Angeles Carrillo-de Sauvage, Géraldine Liot, Gilles Bonvento, Sandrine Humbert, Frédéric Saudou,Philippe Hantraye, Karine Merienne, Alexis-Pierre Bemelmans, Anselme L Perrier, Nicole Déglon and Emmanuel Brouillet: The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.. In: Brain, 2018, 1434-1454 |
| 2017 | Laetitia Francelle, Caroline Lotz, Taigo Outeiro, Emmanuel Brouillet, Karine Merienne: Contribution of Neuroepigenetics to Huntington's Disease. In: Frontiers in Human Neuroscience, 2017, |
| 2017 | Joaqu ?n Pardo; Martin C. Abba; Ezequiel Lacunza; Laetitia Francelle; Gustavo R. Morel; Tiago F. Outeiro; Rodolfo G. Goya: Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats. In: Hippocampus, 2017, |
| 2017 | Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M. Szegö, Renato Martinho, Francesca Munari, Diana F. Lázaro, Sébastien Moniot, Patrícia Guerreiro, Luis Fonseca-Ornelas, Zrinka Marijanovic, Pedro Antas, Ellen Gerhardt, Francisco Javier Enguita, Bruno Fauvet, Deborah Penque, Teresa Faria Pais, Qiang Tong, Stefan Becker, Sebastian Kügler, Hilal Ahmed Lashuel, Clemens Steegborn, Markus Zweckstetter, and Tiago Fleming Outeiro: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.. In: PLoS Biology, 2017, |
| 2016 | Jérémy Pépin, Laetitia Francelle, Maria-Angeles Carrillo-de Sauvage, Lucie de Longprez, Pauline Gipchtein, Karine Cambon, Julien Valette, Emmanuel Brouillet, JulienFlament In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease.. In: NeuroImage, 2016, 53-64 |
| 2015 | Laetitia Francelle, Laurie Galvan, Marie-Claude Gaillard,Philippe Hantraye, Jean-Marc Elalouf, Michel De Chaldée, Nicole Déglon, and Emmanuel Brouillet: Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease. In: Human Molecular Genetics, 2015, 1563-1573 |
| 2015 | Laetitia Francelle, Laurie Galvan, Marie-Claude Gaillard, Benoît Bernay, Gilles Bonvento, Jean-Marc Elalouf, Philippe Hantraye, Nicole Déglon, Michel de Chaldée, Emmanuel Brouillet: Striatal long non coding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.. In: Neurobiology of Aging, 2015, 1601.e7-1601.e16 |
| 2014 | Laetitia Francelle, Laurie Galvan, and Emmanuel Brouillet: Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease.. In: Frontiers in Cellular Neuroscience, 2014, |