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Dr. Sven Ullrich

Profil

Derzeitige StellungPost Doc
FachgebietBioorganische und Biologische Chemie
KeywordsPeptides, Drug development, Antibodies, Future therapeutics, Protein engineering
Auszeichnungen

2024: American Chemical Society CAS Future Leaders Top 100

2024: Royal Australian Chemical Institute Australian Capital Territory Carver Award for PhD Thesis

2024: Royal Australian Chemical Institute National Cornforth Medal for PhD Thesis

2023: Australian National University Chemistry Director's Award for Workplace Excellence

2023: Royal Australian Chemical Institute Organic Chemistry One-Day Symposium Best Student Talk Prize

2022: American Peptide Society Dr Elizabeth A Schram Young Investigator Poster Presentation Award

2022: Australian Research Council Centre of Excellence for Innovations in Peptide & Protein Science Inaugural Conference Early Career Researcher Question Award

2022: National Research Foundation Singapore Global Young Scientists Summit Selected Participant

2022: Royal Australian Chemical Institute National Congress Poster Award

2020: Australian National University International PhD Scholarship & Tuition Fee Waiver

2019: German Academic Exchange Service PROMOS Scholarship

Aktuelle Kontaktadresse

LandDeutschland
OrtLudwigshafen

Gastgeber*innen während der Förderung

Prof. Dr. Hiroaki SugaDepartment of Chemistry, University of Tokyo, Tokyo
Beginn der ersten Förderung01.09.2024

Programm(e)

2024Feodor Lynen-Forschungsstipendien-Programm für Postdocs

Publikationen (Auswahl)

2026Ang, E. and Chang, J. S. and Huang, W.-E. and Ullrich, S. and Vinogradov, A. A. and Suga, H.: Elucidating leader peptide-enzyme dynamics in lactazole biosynthesis using mRNA display. In: J. Am. Chem. Soc., 148, 2026, 2890--2895
2025Ullrich, S. and Nitsche, C.: 4-Fluoro-2,6-dicyanopyridine. Encyclopedia of Reagents for Organic Synthesis. Hoboken, USA: Wiley, 2025.
2025Ullrich, S. and Kumaresan, S. and Rahman, M. G. and Panda, B. and Morewood, R. and Nitsche, C.: Assembling branched and macrocyclic peptides on proteins. In: Chem. Commun., 61, 2025, 3009--3012
2025Ullrich, S. and Panda, B. and Somathilake, U. and Lawes, D. J. and Nitsche, C.: Non-symmetric cysteine stapling in native peptides and proteins. In: Chem. Commun., 61, 2025, 933--936
2025Davies, L. J. and Ghosh, P. and Siryer, S. and Ullrich, S. and Nitsche, C.: Peptide-bismuth tricycles: Maximizing stability by constraint. In: Chem. Eur. J., 31, 2025, e202500064
2025Ullrich, S. and Philippe, G. J.-B. and Li, C. Y. and Suga, H.: Rational design and selection of next-generation cyclotide drugs using the knotted cyclic peptide scaffold MCoTI-II. In: Aust. J. Chem., 78, 2025, CH25086
2025Ullrich, S.: Shaping the future of constrained peptides and compact proteins in drug discovery. In: Aust. J. Chem., 78, 2025, CH25122
2025Ullrich, S. and Nitsche, C.: Synthesis of bicyclic peptides using cyanopyridine-aminothiol click chemistry. Methods in Molecular Biology. New York, USA: Springer, 2025. 13--25
2025He, J. and Illingworth, H. and Ullrich, S. and Ghosh, P. and Ton, J. and Jackson, C. J. and Nitsche, C.: Synthesis, screening and validation of cysteine-reactive fragments as Chikungunya virus protease inhibitors. In: Bioorg. Med. Chem. Lett., 122, 2025, 130176
2024Ullrich, S. and Nitsche, C.: A RaPID response to SARS-CoV-2. In: Isr. J. Chem., 64, 2024, e202300170
2024Ullrich, S. and Nitsche, C.: Bicyclic peptides: Paving the road for therapeutics of the future. In: Pept. Sci., 116, 2024, e24326
2024Harrison, K. and Carlos, P. and Ullrich, S. and Aggarwal, A. and Johansen-Leete, J. and Sasi, V. M. and Barter, I. and Maxwell, J. and Bedding, M. and Larance, M. and Turville, S. and Norman, A. and Jackson, C. and Payne, R. J.: Exploiting hydrophobic amino acid scanning to develop cyclic peptide inhibitors of the SARS-CoV-2 main protease with antiviral activity. In: Chem. Eur. J., 30, 2024, e202401606
2024Ullrich, S. and Somathilake, U. and Shang, M. and Nitsche, C.: Phage-encoded bismuth bicycles enable instant access to targeted bioactive peptides. In: Commun. Chem., 7, 2024, 143
2024Ullrich, S. and Ghosh, P. and Shang, M. and Siryer, S. and Kumaresan, S. and Panda, B. and Davies, L. J. and Somathilake, U. and Patel, A. P. and Nitsche, C.: Synthesis and stability studies of constrained peptide-antimony bicycles. In: Aust. J. Chem., 77, 2024, CH24094
2023Ekanayake, K. B. and Mahawaththa, M. C. and Qianzhu, H. and Abdelkader, E. H. and George, J. and Ullrich, S. and Murphy, R. B. and Fry, S. E. and Johansen-Leete, J. and Payne, R. J. and Nitsche, C. and Huber, T. and Otting, G.: Probing ligand binding sites on large proteins by nuclear magnetic resonance spectroscopy of genetically encoded non-canonical amino acids. In: J. Med. Chem., 66, 2023, 5289--5304
2022Johansen-Leete, J. and Ullrich, S. and Fry, S. E. and Frkic, R. and Bedding, M. J. and Aggarwal, A. and Ashhurst, A. S. and Ekanayake, K. B. and Mahawaththa, M. C. and Sasi, V. M. and Luedtke, S. and Ford, D. J. and O'Donoghue, A. J. and Passioura, T. and Larance, M. and Otting, G. and Turville, S. and Jackson, C. J. and Nitsche, C. and Payne, R. J.: Antiviral cyclic peptides targeting the main protease of SARS-CoV-2. In: Chem. Sci., 13, 2022, 3826--3836
2022Ullrich, S. and George, J. and Coram, A. E. and Morewood, R. and Nitsche, C.: Biocompatible and selective generation of bicyclic peptides. In: Angew. Chem. Int. Ed., 61, 2022, e202208400
2022Ullrich, S. and Ekanayake, K. B. and Otting, G. and Nitsche, C.: Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir. In: Bioorg. Med. Chem. Lett., 62, 2022, 128629
2022Sasi, V. M. and Ullrich, S. and Ton, J. and Fry, S. E. and Johansen-Leete, J. and Payne, R. J. and Nitsche, C. and Jackson, C. J.: Predicting antiviral resistance mutations in SARS-CoV-2 main protease with computational and experimental screening. In: Biochemistry, 61, 2022, 2495--2505
2022Ullrich, S. and Nitsche, C.: SARS-CoV-2 papain-like protease: Structure, function and inhibition. In: ChemBioChem, 23, 2022, e202200327
2022Mekkattu Tharayil, S. and Mahawaththa, M. C. and Feintuch, A. and Maleckis, A. and Ullrich, S. and Morewood, R. and Maxwell, M. J. and Huber, T. and Nitsche, C. and Goldfarb, D. and Otting, G.: Site-selective generation of lanthanoid binding sites on proteins using 4-fluoro-2,6-dicyanopyridine. In: Magn. Reson., 3, 2022, 169--182
2021Ullrich, S. and Sasi, V. M. and Mahawaththa, M. C. and Ekanayake, K. B. and Morewood, R. and George, J. and Shuttleworth, L. and Zhang, X. and Whitefield, C. and Otting, G. and Jackson, C. and Nitsche, C.: Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors. In: Bioorg. Med. Chem. Lett., 50, 2021, 128333
2020Ullrich, S. and Nitsche, C.: The SARS-CoV-2 main protease as drug target. In: Bioorg. Med. Chem. Lett., 30, 2020, 127377