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Profil
| Derzeitige Stellung | Post Doc |
|---|---|
| Fachgebiet | Kardiologie, Angiologie,Entwicklungsbiologie |
| Keywords | Epigenetics, Histone Modification, Cardio-Oncology, Heart Failure, CamKII |
| Auszeichnungen | 2020: Featured Graduate Researcher, UAB School of Medicine 2020: Summa Cum Laude, UAB School of Medicine 2019: "Samuel Barker" Award for Excellence in Graduate Studies 2019: Valedictorian, UAB Graduate Studies 2019: "William Stanley" Early Investigator Award 2018: NIH NHLBI F30 Pre-doctoral Research Grant 2017: "William Featheringill" Young Investigator Award |
Aktuelle Kontaktadresse
| Land | USA |
|---|---|
| Ort | Birmingham |
| Universität/Institution | University of Alabama at Birmingham |
| Institut/Abteilung | School of Medicine |
Gastgeber*innen während der Förderung
| Prof. Dr. med. Johannes Backs | Abteilung Molekulare Kardiologie und Epigenetik, Ruprecht-Karls-Universität Heidelberg, Heidelberg |
|---|---|
| Beginn der ersten Förderung | 01.12.2020 |
Programm(e)
| 2020 | Humboldt-Forschungsstipendien-Programm für Postdocs |
|---|
Publikationen (Auswahl)
| 2024 | Infante, Teresa and Pepin, Mark E and Ruocco, Antonio and Trama, Ugo and Mauro, Ciro and Napoli, Claudio: CDK5R1, GSE1, HSPG2 and WDFY3 as indirect epigenetic-sensitive genes in atrial fibrillation. In: European Journal of Clinical Investigation, 54, 2024, e14135 |
|---|---|
| 2024 | Benincasa, Giuditta and Pepin, Mark E and Russo, Vincenzo and Cacciatore, Francesco and D’Alto, Michele and Argiento, Paola and Romeo, Emanuele and Chiappetti, Rosaria and Laezza, Nunzia and Wende, Adam R and others: High-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction. In: Basic Research in Cardiology, 2024, 1--15 |
| 2024 | Pepin, Mark E and Gupta, Rajat M: The role of endothelial cells in atherosclerosis: insights from genetic association studies. In: The American Journal of Pathology, 194, 2024, 499--509 |
| 2023 | Lanzer, Jan D and Valdeolivas, Alberto and Pepin, Mark and Hund, Hauke and Backs, Johannes and Frey, Norbert and Friederich, Hans-Christoph and Schultz, Jobst-Hendrik and Saez-Rodriguez, Julio and Levinson, Rebecca T: A network medicine approach to study comorbidities in heart failure with preserved ejection fraction. In: BMC medicine, 21, 2023, 267 |
| 2023 | Pepin, Mark E and Konrad, Philipp and Nazir, Sumra and Dewenter, Matthias and Backs, Johannes: Abstract P2076: Disrupting Nicotinamide Nucleotide Transhydrogenase Prevents Cardiometabolic Heart Failure With Preserved Ejection In Mice.. In: Circulation Research, 133, 2023, AP2076--AP2076 |
| 2023 | Benincasa, G and Pepin, ME and Cacciatore, F and Russo, V and D'alto, M and Argiento, P and Romeo, E and Chiappetti, R and Laezza, N and Coscioni, E and others: DNA methylation profiling of circulating CD4+ T cells and network analysis reveal that JUNB, SETD7, and MEF2D genes predict patients with heart failure preserved vs. reduced ejection fraction. In: European Heart Journal, 44, 2023, ehad655--738 |
| 2023 | Pepin, Mark E and Konrad, Philipp and Nazir, Sumra and Dewenter, Matthias and Backs, Johannes: Disrupting Nicotinamide Nucleotide Transhydrogenase Prevents Cardiometabolic Heart Failure With Preserved Ejection In Mice.. CIRCULATION RESEARCH. 2023. |
| 2023 | Pepin, Mark E and Nazir, Sumra and Konrad, Philipp JM and Schreiter, Friederike and Dewenter, Matthias and Backs, Johannes: Genetic Loss of Nicotinamide Nucleotide Transhydrogenase Prevents from Cardiometabolic Heart Failure with Preserved Ejection Fraction. In: bioRxiv, 2023, 2023--04 |
| 2023 | Oeing, Christian U and Pepin, Mark E and Saul, Kerstin B and Agircan, Ay{\c{c}}a Seyhan and Assenov, Yassen and Merkel, Tobias S and Sedaghat-Hamedani, Farbod and Weis, Tanja and Meder, Benjamin and Guan, Kaomei and others: Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure. In: Basic Research in Cardiology, 118, 2023, 9 |
| 2023 | Infante, T and Pepin, ME and Ruocco, A and Mauro, C and Napoli, C: Integrated epigenomic and network analysis identifies novel DNA methylation signature in atrial fibrillation. In: European Heart Journal, 44, 2023, ehad655--409 |
| 2023 | Pepin, Mark E and Vellari, SK and Atri, DS and Reddy, Ankith and Sias-Garcia, Oscar and Hamel, Andrew R and Billaud, Marie and Lee-Kim, Vivian and Segre, Ayellet and Gupta, Rajat: Integrative Analysis of Single-Cell Transcriptomics and Polygenic Risk Scores Uncovers Vascular Smooth Muscle Cell Heterogeneity in Human Aortic Aneurisms. In: Circulation, 148, 2023, A11993--A11993 |
| 2023 | Pepin, ME and Kamal, Y and Reisman, BJ and Rockman, ME and Waller, JP: Making the match and breaking it: values, perceptions, and obstacles of trainees applying into physician-scientist training programs. In: BMC Medical Education, 23, 2023, 763 |
| 2022 | Souder, Jaclyn P and Pepin, Mark E and Seay, Randy L and Lorenz, Robin G and Geisler, William M and Yacoubian, Talene: A novel curricular framework to develop grant writing skills among MD--PhD students. In: Journal of Clinical and Translational Science, 6, 2022, e54 |
| 2022 | Bakshi, Sayan and Potter, Luke and Pepin, Mark and Ha, Chae-myeong and Wende, Adam R: Abstract P3099: Identification Of Hub Genes And Construction Of Protein-protein Interaction (PPI) Network Clusters Define Racially Distinct Signatures Of Ischemic Heart Failure. In: Circulation Research, 131, 2022, AP3099--AP3099 |
| 2022 | Saadatmand, Alireza and Pepin, Mark and Haberkorn, Uwe and Okun, Jürgen and Schlicker, Lisa and Schulze, Almut and Backs, Johannes: CaMKII regulates cardiac metabolic substrate switching during heart failure. In: Journal of Molecular and Cellular Cardiology, 173, 2022, S189 |
| 2022 | Lennermann, David C and Pepin, Mark E and Grosch, Markus and Konrad, Laura and Kemmling, Elena and Hartmann, Joshua and Nolte, Janica L and Clauder-Münster, Sandra and Kayvanpour, Elham and Sedaghat-Hamedani, Farbod and others: Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy. In: American Journal of Physiology-Heart and Circulatory Physiology, 323, 2022, H1296--H1310 |
| 2022 | Duran, Javier and Stolp, Bettina and Becker, Jonas and Dewenter, Matthias and Pepin, Mark and Ambiel, Ina and Grimm, Dirk and Fackler, Oliver and Backs, Johannes: Development of a mouse model for Sars-Cov-2 studies in the heart. In: Journal of Molecular and Cellular Cardiology, 173, 2022, 96 |
| 2022 | Pepin, Mark E and Souder, J Paige and Weaver, Alice N and Lorenz, Robin G and Yacoubian, Talene and Seay, Randy L: Fostering a diverse regional community of physician-scientist trainees. In: Journal of the National Medical Association, 114, 2022, 251--257 |
| 2022 | Bakshi, Sayan and Potter, Luke and Pepin, Mark and Ha, Chae-myeong and Wende, Adam R: Identification Of Hub Genes And Construction Of Proteinprotein Interaction (PPI) Network Clusters Define Racially Distinct Signatures Of Ischemic Heart Failure. CIRCULATION RESEARCH. 2022. |
| 2021 | Pepin, Mark E and Saca, Eyad and Kwon, Soo Y and May, Jori: CASE REPORT: A case of “smoldering” immune-mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke.. In: Clinical Case Reports, 9, 2021, |
| 2021 | Bakshi, Sayan and Pepin, Mark E and Ha, Chae-Myeong and Potter, Luke and Wende, Adam R: Combined Methylomics and Transcriptomics Identifies a Race-Specific Signature of Ischemic Heart Failure in Atrial Natriuretic Peptide Gene Regulation. In: Circulation, 144, 2021, A10692--A10692 |
| 2021 | Justin M. Quiles, Mark E. Pepin, Sini Sunny, Sandeep B. Shelar, Anil K. Challa, Brian Dalley, John R. Hoidal, Steven M. Pogwizd, Adam R. Wende \& Namakkal S. Rajasekaran: Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress. In: Scientific Reports, 11, 2021, 12 |
| 2021 | Pepin, Mark E and Ha, Chae-Myeong and Potter, Luke A and Bakshi, Sayan and Barchue, Joseph P and Asaad, Ayman Haj and Pogwizd, Steven M and Pamboukian, Salpy V and Hidalgo, Bertha A and Vickers, Selwyn M and others: Racial Differences in Cardiovascular and Cerebrovascular Physiology: Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure. In: American Journal of Physiology-Heart and Circulatory Physiology, 320, 2021, H2066 |
| 2021 | Saadatmand, Alireza and Pepin, Mark E and Dewenter, Matthias and Haberkorn, Uwe and Backs, Johannes: The $\delta$C Isoform of Ca2+/Calmodulin-Dependent Protein Kinase II (camk2) Regulates Cardiac Metabolic Substrate Switching in Mice. In: Circulation, 144, 2021, A11062--A11062 |
| 2021 | Pepin, M and Ha, CM and Potter, LA and Bakshi, S and Barchue, J and Pogwizd, SM and Pamboukian, SV and Hidalgo, B and Wende, AR: The cardiac epigenome encodes racial and socioeconomic differences among patients with end-stage heart failure. EUROPEAN JOURNAL OF HEART FAILURE. 2021. 60--60 |
| 2021 | Pepin, Mark E and Schiano, Concetta and Miceli, Marco and Benincasa, Giuditta and Mansueto, Gelsomina and Grimaldi, Vincenzo and Soricelli, Andrea and Wende, Adam R and Napoli, Claudio: The human aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia. In: Experimental cell research, 400, 2021, 112485 |
| 2020 | Pepin, Mark E and Infante, Teresa and Benincasa, Giuditta and Schiano, Concetta and Miceli, Marco and Ceccarelli, Simona and Megiorni, Francesca and Anastasiadou, Eleni and Della Valle, Giovanni and Fatone, Gerardo and others: Differential DNA methylation encodes proliferation and senescence programs in human adipose-derived mesenchymal stem cells. In: Frontiers in Genetics, 11, 2020, 346 |
| 2020 | Brahma, Manoja K and Ha, Chae-Myeong and Pepin, Mark E and Mia, Sobuj and Sun, Zhihuan and Chatham, John C and Habegger, Kirk M and Abel, Evan Dale and Paterson, Andrew J and Young, Martin E and others: Increased glucose availability attenuates myocardial ketone body utilization. In: Journal of the American Heart Association, 9, 2020, e013039 |
| 2020 | Wende, Adam R and Schell, John C and Ha, Chae-Myeong and Pepin, Mark E and Khalimonchuk, Oleh and Schwertz, Hansjörg and Pereira, Renata O and Brahma, Manoja K and Tuinei, Joseph and Contreras-Ferrat, Ariel and others: Maintaining myocardial glucose utilization in diabetic cardiomyopathy accelerates mitochondrial dysfunction. In: Diabetes, 69, 2020, 2094--2111 |
| 2020 | Webb, William M and Irwin, Ashleigh B and Pepin, Mark E and Henderson, Benjamin W and Huang, Victoria and Butler, Anderson A and Herskowitz, Jeremy H and Wende, Adam R and Cash, Andrew E and Lubin, Farah D: The SETD6 methyltransferase plays an essential role in hippocampus-dependent memory formation. In: Biological psychiatry, 87, 2020, 577--587 |
| 2020 | Potter, Luke A and Pepin, Mark E and Ha, Chae-myeong and Bakshi, Sayan and Wende, Adam R: Transcriptomic Analysis of End-stage Human Heart Failure Highlights Strong Interaction Effect Between Race and Diabetes. In: Circulation Research, 127, 2020, A511--A511 |
| 2019 | Potter, Luke A and Pepin, Mark E and Wende, Adam R: A Novel Role of Cardiac DNA Methylation as a Regulator of Fibrosis in Human Diabetic Heart Failure. In: Circulation Research, 125, 2019, A945--A945 |
| 2019 | Pepin, Mark E and Ha, Chae-Myeong and Drakos, Stavros and Tristani-Firouzi, Martin and Selzman, Craig and Fang, James C and Wende, Adam R and Wever-Pinzon, Omar: A novel role of genome-wide DNA methylation as a regulator of cardiac gene expression in end-stage human heart failure. In: Circulation, 140, 2019, A10763--A10763 |
| 2019 | Pepin, Mark E and Drakos, Stavros and Ha, Chae-Myeong and Tristani-Firouzi, Martin and Selzman, Craig H and Fang, James C and Wende, Adam R and Wever-Pinzon, Omar: Chromatin and Epigenetics in Cardiovascular Disease: DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure. In: American Journal of Physiology-Heart and Circulatory Physiology, 317, 2019, H674 |
| 2019 | Mark Emile Pepin, Stavros Drakos, Chae-Myeong Ha, Martin Tristani-Firouzi, Craig H Selzman, James C. Fang, Adam Raymond Wende, and Omar Wever-Pinzon: DNA Methylation Reprograms Cardiac Metabolic Gene Expression in End-Stage Human Heart Failure.. In: American Journal of Physiology - Heart and Circulatory Physiology, 2019, |
| 2019 | Pepin, Mark E and Koentges, Christoph and Pfeil, Katharina and Gollmer, Johannes and Kersting, Sophia and Wiese, Sebastian and Hoffmann, Michael M and Odening, Katja E and Mühlen, Constantin von zur and Diehl, Philipp and others: Dysregulation of the mitochondrial proteome occurs in mice lacking adiponectin receptor 1. In: Frontiers in endocrinology, 10, 2019, 872 |
| 2019 | Mark E. Pepin, William M. Webb, Sushma Boppana, Alice N. Weaver, Randy L. Seay, Donald M. Dempsey, James H. Willig, William M. Geisler, Robin G. Lorenz: Gamification: an Innovative Approach to Reinforce Clinical Knowledge for MD-PhD Students During Their PhD Research Years. In: Medical Science Educator, 2019, |
| 2019 | Pepin, Mark E and Ha, Chae-Myeong and Crossman, David K and Litovsky, Silvio H and Varambally, Sooryanarayana and Barchue, Joseph P and Pamboukian, Salpy V and Diakos, Nikolaos A and Drakos, Stavros G and Pogwizd, Steven M and others: Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure. In: Laboratory Investigation, 99, 2019, 371--386 |
| 2019 | Gollmer, J and Koentges, C and Pepin, M and Pfeil, K and Wende, AR and Bode, C and Zirlik, A and Bugger, H: P3480 Tissue-specific regulation of the mitochondrial proteome by adiponectin receptor 1. In: European Heart Journal, 40, 2019, ehz745--0350 |
| 2019 | Pepin, Mark E and Bickerton, Hayden H and Bethea, Maigen and Hunter, Chad S and Wende, Adam R and Banerjee, Ronadip R: Prolactin receptor signaling regulates a pregnancy-specific transcriptional program in mouse islets. In: Endocrinology, 160, 2019, 1150--1163 |
| 2019 | : Resident macrophages reprogram toward a developmental state after acute kidney injury. In: JCI Insight, 2019, |
| 2019 | Pepin, Mark and Wende, Adam and Banerjee, Ronadip: SAT-163 Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets. In: Journal of the Endocrine Society, 3, 2019, SAT--163 |
| 2019 | Gollmer, J and Koentges, C and Pepin, M and Pfeil, K and Wende, AR and Bode, C and Zirlik, A and Bugger, H: Tissue-specific regulation of the mitochondrial proteome by adiponectin receptor 1. EUROPEAN HEART JOURNAL. 2019. 2096--2096 |
| 2018 | Pepin, Mark E and Padgett, Lindsey E and McDowell, Ruth E and Burg, Ashley R and Brahma, Manoja K and Holleman, Cassie and Kim, Teayoun and Crossman, David and Kutsch, Olaf and Hubert, M Tse and others: Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance. In: Molecular metabolism, 12, 2018, 48--61 |
| 2018 | Ba{\~n}os, James H and Pepin, Mark E and Van Wagoner, Nicholas: Class-wide access to a commercial step 1 question bank during preclinical organ-based modules: a pilot project. In: Academic Medicine, 93, 2018, 486--490 |
| 2018 | Koentges, Christoph and Pepin, Mark E and Müsse, Carolyn and Pfeil, Katharina and Alvarez, Sonia V Viteri and Hoppe, Natalie and Hoffmann, Michael M and Odening, Katja E and Sossalla, Samuel and Zirlik, Andreas and others: Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans. In: Basic research in cardiology, 113, 2018, 1--17 |
| 2018 | Kim, Teayoun and Nason, Shelly and Holleman, Cassie and Pepin, Mark and Wilson, Landon and Berryhill, Taylor F and Wende, Adam R and Steele, Chad and Young, Martin E and Barnes, Stephen and others: Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21. In: Diabetes, 67, 2018, 1773--1782 |
| 2018 | Quiles, Justin M and Pepin, Mark E and Cinghu, Senthilkumar and Challa, Anil Kumar and Wende, Adam R and Crossman, David and Namakkal-Soorappan, Rajasekaran: Nrf2-Dependent Transcriptional and Post-Transcriptional Regulatory Responses in Reductive Stress Myocardium. In: Circulation Research, 123, 2018, A234--A234 |
| 2017 | Wende, Adam R and Kim, Jaetaek and Holland, William L and Wayment, Benjamin E and O’Neill, Brian T and Tuinei, Joseph and Brahma, Manoja K and Pepin, Mark E and McCrory, Mark A and Luptak, Ivan and others: Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. In: American Journal of Physiology-Heart and Circulatory Physiology, 313, 2017, H1098--H1108 |
| 2017 | Pepin, Mark E and Crossman, David K and Barchue, Joseph P and Pamboukian, Salpy V and Pogwizd, Steven M and Wende, Adam R: Glucose-Mediated Remodeling of Cardiac DNA Methylation. In: Circulation Research, 121, 2017, A15--A15 |
| 2017 | Brahma, Manoja K and Pepin, Mark E and Wende, Adam R: My sweetheart is broken: role of glucose in diabetic cardiomyopathy. In: Diabetes \& metabolism journal, 41, 2017, 1--9 |
| 2016 | Pepin, Mark E and Wende, Adam R: Diabetes and Glucose Alone Regulate Cardiac ABAT Levels. In: The FASEB Journal, 30, 2016, 1273--9 |
| 2016 | Brahma, Manoja K and McCrory, Mark A and Paterson, Andrew J and Pepin, Mark E and Young, Martin E and Wende, Adam R: Regulation of Myocardial Ketone Oxidative Proteins by Increased O-GlcNAcylation. In: The FASEB Journal, 30, 2016, 1273--1 |
| 2013 | MacKenzie, Matthew G and Hamilton, David Lee and Pepin, Mark and Patton, Amy and Baar, Keith: Inhibition of myostatin signaling through Notch activation following acute resistance exercise. In: PloS one, 8, 2013, e68743 |
| 2012 | Kelly, Jesse C and Pepin, Mark and Huber, Dale L and Bunker, Bruce C and Roberts, Mark E: Reversible Control of Electrochemical Properties Using Thermally-Responsive Polymer Electrolytes. In: Advanced Materials, 24, 2012, 886--889 |
| n.n. | Lennermann, David C and Pepin, Mark E and Grosch, Markus and Konrad, Laura and Kemmling, Elena and Hartmann, Joshua and Nolte, Janica L and Clauder-Münster, Sandra and Kayvanpour, Elham and Sedaghat, Farbod: Deep phenotyping of two pre-clinical mouse models and a cohort of RBM20 mutation. n.n., |
| n.n. | Weaver, MD and Seay, Randy L and Dempsey, Donald M and Willig, James H and Geisler, William M and Lorenz, Robin G: Gamification: An Innovative Approach to Reinforce Clinical Knowledge for MD-PhD Students During Their PhD Research Years. n.n., |
| n.n. | Wende, Adam R and Kim, Jaetaek and Holland, William L and Wayment, Benjamin E and O’Neill, Brian T and Tuinei, Joseph and Brahma, Manoja K and Pepin, Mark E and McCrory, Mark A and Luptak, Ivan and others: Glucose transporter 4 (GLUT4) deficient hearts develop maladaptive hypertrophy in response to physiologic or pathologic stresses 2. n.n., |
| n.n. | Webb, Fern J and Irwin, Ashleigh B and Pepin, Mark E and Henderson, Benjamin W and Huang, Victoria and Butler, Anderson A and Herskowitz, Jeremy H and Wende, Adam R and Cash, Andrew E and Lubin, Farah D: Open Library of Bioscience. n.n., |